Trip from Kissee Mills, MO to O'Fallon, MO

Last recalculated Apr 16, 2026

Drive Time

5h 1m

Distance

254.6 mi

410 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$40

one way

EV Charging

Excellent

26 DC fast

Best Time to Leave

Save up to 41 min

4 AM

4h 48m ★

6 AM

5h 2m

8 AM

5h 29m

10 AM

5h 11m

12 PM

5h 9m

3 PM

5h 13m

5 PM

5h 28m

8 PM

4h 54m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly

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Kissee Mills, MO

Lena Khrupina

O'Fallon, MO

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Trip Overview

The drive from Kissee Mills, MO to O'Fallon, MO covers 254.6 miles and takes about 5h 1m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on I 44, US 160, Manchester Road for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 170.3 miles on I 44. At current regular gas prices, budget about $39.84 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

127.3 miles from Kissee Mills, MO

A natural place for your longest stop of the day , about 2h 27m into the drive .

Who Is This Route For?

Weekend Trip

Doable as a same-day drive at 5h 1m. Total distance: 254.6 miles.

Family Friendly

Moderate complexity with 1 natural rest stops along the way.

Solo Traveler

5h 1m drive, comfortable solo distance.

First-Time Driver

Mostly highway driving (84%). Some complex stretches to watch for.

Drive Character

This is a 5h 1m highway drive covering 254.6 miles, with most of the trip on I 44 and US 160. The longest continuous stretch is about 170.3 miles on I 44.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.

There are about 35 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

I 44 is the longest continuous segment at about 170.3 miles.

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on I 44 and US 160. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 1.1 miles in near US 160; MO 76.

Driving Effort 7/10

Demanding - plan breaks and stay ahead of the key maneuvers

Balances navigation complexity with total wheel time.

This is a demanding drive. With 17 significant decision points across 254.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 1.1 miles (US 160; MO 76): Sharp turn - reduce speed on approach; at 221.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 221.5 miles (MO 100 / Manchester Road): Lane positioning matters here.

Critical Maneuvers

5 of 17 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

1.1 mi into trip | ~1m in | US 160; MO 76

Turn sharp left onto US 160; MO 76

Sharp turn - reduce speed on approach

221.3 mi into trip | ~4h 8m in

Take the exit toward I 44 Business, MO 100 East: Gray Summit

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 253 Toward I 44 Business, MO 100 East: Gray Summit

221.5 mi into trip | ~4h 9m in | MO 100 / Manchester Road

Turn left onto MO 100 / Manchester Road

Lane positioning matters here

Use the straight lane.

235.1 mi into trip | ~4h 28m in | MO 109

Enter roundabout onto MO 109

Roundabout - know your exit number before entering

247.1 mi into trip | ~4h 48m in

Take the exit toward MO K: O'Fallon

Exit ramp - move to the correct lane early. Lane positioning matters here

Use the straight / slight right lanes. Exit 9 Toward MO K: O'Fallon

Main Roads

Road	Distance	Duration
I 44	170.3 mi	3h 3m
US 160	15.4 mi	23m
Manchester Road	13.4 mi	18m
American Legion Memorial Highway	12.2 mi	14m
US Highway 65	12 mi	13m
Schoolcraft Freeway	10.7 mi	13m
MO K	6.3 mi	11m
MO 109	4.9 mi	7m

Longest stretch: I 44 — 170.3 mi, about 3h 3m

Turn-by-Turn Driving Directions

Step-by-step road directions between Kissee Mills, MO and O'Fallon, MO.

Start on MO O

97 ft · 2 sec · MO O

Turn slight left onto US 160

1.1 mi · 1 min · US 160

Turn sharp left onto US 160; MO 76

2.9 mi · 4 min · US 160; MO 76

Enter roundabout onto US 160

126 ft · 2 sec · US 160

Continue on US 160

11 mi · 16 min · US 160

Take the ramp

0.2 mi · 31 sec

Merge onto US 65

1.3 mi · 1 min · American Legion Memorial Highway

Continue on US 65

12 mi · 13 min · US Highway 65

Continue on US 65

11 mi · 12 min · American Legion Memorial Highway

Continue on US 65

11 mi · 13 min · Schoolcraft Freeway

Use the straight / slight right lanes.

Take the exit

0.6 mi · 54 sec

Toward I 44 East: Saint Louis

Merge onto I 44

170 mi · 3 hr 3 min · I 44

Take the exit

0.2 mi · 27 sec

Exit 253 Toward I 44 Business, MO 100 East: Gray Summit Use the slight right lane.

Turn left onto MO 100

13 mi · 18 min · Manchester Road

Use the straight lane.

Take the exit

0.2 mi · 30 sec

Toward MO 109

Enter roundabout onto MO 109

224 ft · 4 sec · MO 109

Continue on MO 109

515 ft · 10 sec · MO 109

Enter roundabout onto MO 109

98 ft · 1 sec · MO 109

Continue on MO 109

0.4 mi · 45 sec · MO 109

Enter roundabout onto MO 109

94 ft · 2 sec · MO 109

Continue on MO 109

4.3 mi · 6 min · MO 109

Enter roundabout onto South Eatherton Road

94 ft · 1 sec · South Eatherton Road

Continue on South Eatherton Road

2.4 mi · 4 min · South Eatherton Road

Continue on Olive Street Road

0.9 mi · 1 min · Olive Street Road

Take the ramp onto Chesterfield Airport Road

0.7 mi · 1 min · Chesterfield Airport Road

Merge onto I 64; US 40; US 61

3.1 mi · 3 min · Avenue of the Saints

Use the straight lane.

Take the exit

327 ft · 6 sec

Exit 9 Toward MO K: O'Fallon Use the straight / slight right lanes.

Merge onto North Outer Road

0.3 mi · 31 sec · North Outer Road

Continue on North Outer Road

0.2 mi · 17 sec · North Outer Road

Turn right onto MO K

3.3 mi · 5 min · MO K

Continue on MO K

1.5 mi · 2 min · MO K

Use the right lane.

Continue on MO K

1.6 mi · 3 min · MO K

Use the right lane.

Continue on South Main Street

0.6 mi · 1 min · South Main Street

Turn right

25 ft · 1 sec

Arrive at destination

Trip Plan

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 127.3 miles from Kissee Mills, MO, or about 2h 27m into the drive.

The longest continuous stretch on this route runs about 170.3 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 56 miles or 1h 10m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 127.3 miles or 2h 27m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 3h 55m

Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.

Before You Leave

Open the route before leaving Kissee Mills, MO so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Kissee Mills, MO

This is one driving day of about 254.6 miles and 5h 1m.

Your first comfortable stop window is around 56 miles from Kissee Mills, MO.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

The longest stretch is on I 44 for about 170.3 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 127.3 mi from Kissee Mills, MO · 2h 27m into the drive

Mid-route town

Meal stop

Cuba, MO

127 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Popular next leg

Cuba, MO to O'Fallon, MO

78.8 mi · 1h 42m

Pacing Suggestions

Marshfield, MO

Fuel and coffee

A short stop after about 56 miles helps settle the day before fatigue starts building.

Waynesville, MO

Meal break

The midpoint is around 127.3 miles from Kissee Mills, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before I 44 if your tank is already low. That segment runs about 170.3 miles.

Arriving in O'Fallon, MO

The final approach into O'Fallon, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around O'Fallon, MO.

After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

National Parks Near This Route

Worth a detour if your schedule allows.

Wilson's Creek National Battlefield

National Battlefield

Wilson's Creek was the first major Civil War battle fought west of the Mississippi River, and where the first Union general was killed in action. The costly Southern victory on August 10, 1861, focuse...

11 mi from route ~27 min detour Free near mile 43.9

Caution: BE AWARE OF HIGH-WATER DANGER

View on nps.gov

Gateway Arch National Park

National Park

Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...

25 mi from route ~63 min detour $19 near mile 237.1

View on nps.gov

Park data from the National Park Service API. Alerts update every 2 hours.

Fuel & Cost

Regular Gas

$39.84 one way

$79.67 round trip

$3.97/gal 25.4 MPG avg 89 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.36	$43.74	$87.47
premium	$4.89	$49.03	$98.07
diesel	$5.61	$56.26	$112.51

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$40

Meals

$25–$50

Total

$65–$90

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 89.1 kg one way. Prices: EIA weekly data, 2026-04-13.

EV Charging Along Route

26 DC fast chargers · Coverage: excellent

Buc-ee's - Tesla Supercharger

Springfield, MO

Tesla

16 DCFC

The District - Tesla Supercharger

Chesterfield, MO

Tesla

12 DCFC

Macadoodles Fine Wine & Spirits - Tesla Supercharger

Springfield, MO

Tesla

10 DCFC

Target - Tesla Supercharger

Branson, MO

Tesla

8 DCFC

Casey's - Tesla Supercharger

St. Robert, MO

Tesla

8 DCFC

Bandana's Bar-B-Q - Tesla Supercharger

Rolla, MO

Tesla

8 DCFC

Laura Ford of Sullivan, LLC - DCFC

Sullivan, MO

Blink Network

6 DCFC

Simon St. Louis Premium Outlets (Chesterfield, MO)

Chesterfield, MO

Electrify America

6 DCFC

Tesla: 6 ChargePoint Network: 5 EV Connect: 4 Blink Network: 4 Electrify America: 3 eVgo Network: 2 FCN: 1 SYNERGEV: 1

Station data from NREL Alternative Fuel Stations database.

Driving Electric?

About $27 in charging · 0 stops · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	76.4	0	$26.73	$12.22
Efficient EV	63.7	0	$22.28	$10.18
EV Truck/SUV	101.8	1	$35.64	$16.29

Gas CO2

89 kg

EV CO2

30 kg (66% less)

Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast as of Apr 15, 2026

Origin

Kissee Mills, MO

Evening in Kissee Mills on Thursday

Local time

5:17 PM

CDT

Current temp

77°F

Unavailable

Live forecast

Destination

O'Fallon, MO

Evening in O'Fallon on Thursday

Local time

5:17 PM

CDT

Current temp

57°F

Unavailable

Live forecast

75°F

Cuba, MO

127 mi in

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

20 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

5h 1m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Kissee Mills, MO to O'Fallon, MO covers 254.6 miles and takes about 5h 1m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are I 44, US 160, Manchester Road. Most of the drive stays on highways, so watch for ramps and exits.

This is a comfortable same-day trip.

The midpoint is about 127.3 miles from Kissee Mills, MO. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $39.80 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.

Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

The route from Kissee Mills, MO to O'Fallon, MO does not surface many named destination signs beyond the main corridor.

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