The drive from Maryville, MO to St. Louis, MO covers 345.5 miles and takes about 6h 34m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, I 29 for much of the mileage,
and the overall profile is mixed drive.
The longest uninterrupted segment is about 135.3 miles on Dwight D. Eisenhower Highway.
At current regular gas prices, budget about $54.01 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
172.8 miles from Maryville, MO
A natural place for your longest stop of the day
, about 3h 12m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 34m. Total distance: 345.5 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 34m drive, plan rest stops for pacing.
Scenic Drive
Mixed drive route profile with national parks nearby.
Drive Character
The drive from Maryville, MO to St. Louis, MO covers 345.5 miles and takes about 6h 34m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 29 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D. Eisenhower Highway is the longest continuous segment at about 135.3 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 74.8 miles in near I 435.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 14 significant decision points across 345.5 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 74.8 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 102.7 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 103 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Critical Maneuvers
5 of 14 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
8
74.8 mi into trip|~1h 24m in|I 435
Keep slight right at fork onto I 435 toward I 435 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Exit 14
Toward I 435 East: Saint Louis
7
102.7 mi into trip|~1h 55m in|US 24
Keep slight right at fork onto US 24 toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 63
Toward I 70, US 24 West, US 40: Saint Louis, Ka...
7
103 mi into trip|~1h 55m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Toward I 70 East: Saint Louis
7
104.2 mi into trip|~1h 57m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left / straight lanes.
Toward I 70 East: Saint Louis
7
344.8 mi into trip|~6h 32m in
Take the exit toward 14th Street
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 39A
Toward 14th Street
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Maryville, MO and St. Louis, MO, road signs point toward Kansas City and Sports Complex.
Kansas City
102.7 mi in|~1h 55m|via US 24
Sports Complex
102.7 mi in|~1h 55m|via US 24
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
I 29
39.4 mi
42m
US 71 (MO)
30 mi
34m
I 435
28 mi
30m
Avenue of the Saints
27.7 mi
33m
Jack Buck Memorial Highway
5.8 mi
7m
Daniel Boone Expressway
5.7 mi
7m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Turn-by-Turn Driving Directions
Step-by-step road directions between Maryville, MO and St. Louis, MO.
1
Start on MO 46
134 ft·10 sec·East 1st Street
2
Turn left onto US 71 Business
2.2 mi·3 min·South Main Street
3
Continue on US 71
30 mi·34 min·US 71 (MO)
4
Take the exit onto US 59; US 71
3.2 mi·3 min·US 59; US 71
Toward I 29 South, US 71 South, US 59 South: Kansas City
5
Continue on I 29; US 71
37 mi·40 min·I 29; US 71
6
Merge onto I 29; I 435; US 71
2.2 mi·2 min·I 29; I 435; US 71
Use the straight / slight right lanes.
7
Keep slight right at fork onto I 435
28 mi·30 min·I 435
Exit 14Toward I 435 East: Saint LouisUse the straight / slight right lanes.
8
Keep slight right at fork onto US 24
0.3 mi·23 sec·US 24
Exit 63Toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
9
Keep slight left at fork
1.2 mi·1 min
Toward I 70 East: Saint LouisUse the straight / slight right lanes.
10
Keep slight left at fork
469 ft·11 sec
Toward I 70 East: Saint LouisUse the slight left / straight lanes.
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$54.01 one way
$108.03 round trip
$3.97/gal25.4 MPG avg121 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$59.31
$118.61
premium
$4.89
$66.49
$132.98
diesel
$5.61
$76.28
$152.56
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$54
Meals
$25–$50
Total
$79–$104
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 120.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
3 DC fast chargers
· Coverage: fair
Hy-Vee - Tesla Supercharger
St. Joseph, MO
Tesla
8 DCFC
Casey's - Maryville
Maryville, MO
FCN
4 DCFC
EVERGY @SPEEDYS-440A
St Joseph, MO
ChargePoint Network
1 DCFC
FCN: 1
ChargePoint Network: 1
Tesla: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $36 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
103.6
1
$36.28
$16.58
Efficient EV
86.4
0
$30.23
$13.82
EV Truck/SUV
138.2
1
$48.37
$22.11
Gas CO2
121 kg
EV CO2
40 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Maryville, MO
Late night
in Maryville on Saturday
Local time
2:02 AM
CDT
Current temp
53°F
Unavailable
Live forecast
Destination
St. Louis, MO
Late night
in St. Louis on Saturday
Local time
2:02 AM
CDT
Current temp
74°F
Unavailable
Live forecast
74°F
Columbia, MO
173 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
21 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 34m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Maryville, MO to St. Louis, MO covers 345.5 miles and takes about 6h 34m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, I 29. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 172.8 miles from Maryville, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $54.01 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 14 significant decision points across 345.5 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 74.8 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 102.7 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 103 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Between Maryville, MO and St. Louis, MO, road signs point toward Kansas City and Sports Complex.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
