The drive from Mifflinville, PA to Pittsburgh, PA covers 230.4 miles and takes about 4h 43m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Keystone Shortway, William Penn Highway, I 99 for much of the mileage,
and the overall profile is turn-heavy local drive.
The longest uninterrupted segment is about 80.8 miles on Keystone Shortway.
At current regular gas prices, budget about $38.20 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
115.2 miles from Mifflinville, PA
A natural place for your longest stop of the day
, about 2h 8m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 43m. Total distance: 230.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 43m drive, comfortable solo distance.
Scenic Drive
Turn-heavy local drive route profile with national parks nearby.
Drive Character
Expect a 4h 43m drive with frequent turns across 230.4 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 19 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Keystone Shortway is the longest continuous segment at about 80.8 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 81.8 miles in.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 11 significant decision points across 230.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 81.8 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 106.2 miles (I 99; US 220): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 216.1 miles (I 376; US 22 / Penn-Lincoln Parkway East): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 11 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
81.8 mi into trip|~1h 29m in
Take the exit toward I 99 South, US 220 South, PA 26: Bellefonte
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 161
Toward I 99 South, US 220 South, PA 26: Bellefo...
6
106.2 mi into trip|~1h 58m in|I 99; US 220
Keep slight left at fork onto I 99; US 220 toward I 99 South, US 220 South: Port Matilda, Altoona
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 99 South, US 220 South: Port Matilda,...
8
216.1 mi into trip|~4h 22m in|I 376; US 22 / Penn-Lincoln Parkway East
Keep slight right at fork onto I 376; US 22 / Penn-Lincoln Parkway East toward I 376 West, US 22 West: Pittsburgh
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 376 West, US 22 West: Pittsburgh
7
229.6 mi into trip|~4h 40m in
Take the exit toward Second Avenue
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 71B
Toward Second Avenue
7
230.3 mi into trip|~4h 42m in|Grant Street
Turn right onto Grant Street
Lane positioning matters here
Use the right lane.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Mifflinville, PA and Pittsburgh, PA, road signs point toward Altoona and Hollidaysburg.
Altoona
106.2 mi in|~1h 58m|via I 99; US 220
Hollidaysburg
140 mi in|~2h 35m
Main Roads
Road
Distance
Duration
Keystone Shortway
80.8 mi
1h 27m
William Penn Highway
61.2 mi
1h 25m
I 99
33.8 mi
36m
Jacksonville Road
24.2 mi
28m
Penn-Lincoln Parkway East
13.5 mi
18m
Admiral Peary Highway
13.4 mi
19m
West 3rd Street
0.7 mi
1m
Second Avenue
0.3 mi
<1m
Longest stretch:
Keystone Shortway
— 80.8 mi, about 1h 27m
Turn-by-Turn Driving Directions
Step-by-step road directions between Mifflinville, PA and Pittsburgh, PA.
1
Start on Market Street
120 ft·6 sec·Market Street
2
Turn right onto PA 339
0.7 mi·1 min·West 3rd Street
3
Take the ramp
0.2 mi·25 sec
4
Merge onto I 80
81 mi·1 hr 27 min·Keystone Shortway
5
Take the exit
0.3 mi·53 sec
Exit 161Toward I 99 South, US 220 South, PA 26: Bellefonte
6
Turn left onto US 220; PA 26
24 mi·28 min·Jacksonville Road
Use the straight lane.
7
Keep slight left at fork onto I 99; US 220
34 mi·36 min·I 99; US 220
Toward I 99 South, US 220 South: Port Matilda, Altoona
8
Take the exit
0.8 mi·1 min
Toward US 22: Ebensburg, Hollidaysburg
9
Continue on this road
0.5 mi·43 sec·this road
10
Continue on US 22
16 mi·19 min·William Penn Highway
11
Continue on US 22
13 mi·19 min·Admiral Peary Highway
Use the straight lane.
12
Continue on US 22
45 mi·1 hr 6 min·William Penn Highway
Use the straight / right lanes.
13
Keep slight right at fork onto I 376; US 22
13 mi·18 min·Penn-Lincoln Parkway East
Toward I 376 West, US 22 West: PittsburghUse the slight left lane.
14
Take the exit
0.2 mi·38 sec
Exit 71BToward Second AvenueUse the straight / slight right lanes.
15
Turn straight onto Second Avenue
0.3 mi·41 sec·Second Avenue
16
At end of road, turn right onto Ross Street
0.2 mi·32 sec·Ross Street
17
Turn left onto Fifth Avenue
352 ft·10 sec·Fifth Avenue
18
Turn right onto Grant Street
513 ft·21 sec·Grant Street
Use the right lane.
19
Arrive at destination
Grant Street
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 115.2 miles from Mifflinville, PA, or about 2h 8m into the drive.
The longest continuous stretch on this route runs about 80.8 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 51 miles or 56m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 115.2 miles or 2h 8m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 42m
Traffic, exits, and arrival timing usually matter more near Pittsburgh, PA than in the middle of the route.
Before You Leave
+
Open the route before leaving Mifflinville, PA so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Mifflinville, PA
This is one driving day of about 230.4 miles and 4h 43m.
Your first comfortable stop window is around 51 miles from Mifflinville, PA.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Keystone Shortway for about 80.8 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 115.2 mi from Mifflinville, PA
· 2h 8m into the drive
The midpoint is around 115.2 miles from Mifflinville, PA, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel check
Top up before Keystone Shortway if your tank is already low. That segment runs about 80.8 miles.
Arriving in Pittsburgh, PA
The final approach into Pittsburgh, PA usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Pittsburgh, PA.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Johnstown Flood National Memorial
National Memorial
The South Fork Dam failed on Friday, May 31, 1889, and unleashed 20,000,000 tons of water that devastated Johnstown, PA. The flood killed 2,209 people but it brought the nation and the world together...
9 mi from route
~22 min detour
Free
near mile 166.8
On Tuesday morning, September 11, 2001, the U.S. came under attack when four commercial airliners were hijacked and used to strike targets on the ground. Nearly 3,000 people tragically lost their live...
27 mi from route
~68 min detour
Free
near mile 166.8
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$38.20 one way
$76.39 round trip
$4.21/gal25.4 MPG avg81 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$41.83
$83.67
premium
$4.93
$44.68
$89.37
diesel
$5.61
$50.87
$101.74
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$38
Meals
$25–$50
Total
$63–$88
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 80.6 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $24 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
69.1
0
$24.19
$11.06
Efficient EV
57.6
0
$20.16
$9.22
EV Truck/SUV
92.2
1
$32.26
$14.75
Gas CO2
81 kg
EV CO2
27 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 13, 2026
Origin
Mifflinville, PA
Afternoon
in Mifflinville on Friday
Local time
4:44 PM
EDT
Current temp
44°F
Unavailable
Live forecast
Destination
Pittsburgh, PA
Afternoon
in Pittsburgh on Friday
Local time
4:44 PM
EDT
Current temp
81°F
Mostly Sunny
W 16 mph8% chanceLive forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
37 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 43m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Mifflinville, PA to Pittsburgh, PA covers 230.4 miles and takes about 4h 43m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Keystone Shortway, William Penn Highway, I 99. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 115.2 miles from Mifflinville, PA. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $38.20 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 11 significant decision points across 230.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 81.8 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 106.2 miles (I 99; US 220): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 216.1 miles (I 376; US 22 / Penn-Lincoln Parkway East): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Mifflinville, PA and Pittsburgh, PA, road signs point toward Altoona and Hollidaysburg.
Yes. Nearby national parks include Johnstown Flood National Memorial and Flight 93 National Memorial.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
