Origin
Mound City, MO
Night in Mound City on Wednesday
Local time
11:21 PM
CDT
Current temp
75°F
Unavailable
Live forecast
Trip from Mound City, MO to St. Louis, MO
Last recalculated Apr 16, 2026
Drive Time
5h 17m
Distance
340.9 mi
549 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$53
one way
Best Time to Leave
4 AM
5h 4m
★
6 AM
5h 18m
8 AM
5h 45m
10 AM
5h 27m
12 PM
5h 25m
3 PM
5h 29m
5 PM
5h 43m
8 PM
5h 10m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Mound City, MO
Wikimedia Commons
Trip Overview
The drive from Mound City, MO to St. Louis, MO covers 340.9 miles and takes about 5h 17m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on State Street, I 29 South, I 435 East for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $53.30 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
170.5 miles from Mound City, MO
A natural place for your longest stop of the day , about 2h 38m into the drive .
Drive Character
Expect a 5h 17m drive with frequent turns across 340.9 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 29 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
State Street is one of the defining roads on this drive.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way.
Route Complexity
3/10
Easy - simple navigation with a manageable amount of wheel time
This is a straightforward 5h 17m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
This route does not have any notably tricky sections. Most of the drive from Mound City, MO to St. Louis, MO is straightforward, with well-signed roads and simple exits.
Main Roads
| Road | Distance | Duration |
|---|---|---|
| State Street | — | — |
| I 29 South | — | — |
| I 435 East | — | — |
| I 70 | — | — |
| I 70 East | — | — |
| George Brett Super Highway | — | — |
| Truman/Eisenhower Presidential Highway | — | — |
| Clifton J | — | — |
Some road-level metrics are being recalculated.
Longest stretch:
State Street
— detailed segment metrics are refreshing.
Turn-by-Turn Driving Directions
Step-by-step road directions between Mound City, MO and St. Louis, MO.
1
Start on the route
98 ft
·
9 sec
·
the route
2
Turn right onto State Street
0.2 mi
·
49 sec
·
State Street
3
Turn left
0.3 mi
·
33 sec
4
Take the ramp left toward I 29 South: Saint Joseph
0.2 mi
·
22 sec
·
I 29 South: Saint Joseph
5
Merge slight left
67 mi
·
1 hr 12 min
6
Merge slight right
2.2 mi
·
2 min
7
Keep slight right to continue on I 435 East: Saint Louis
28 mi
·
30 min
·
I 435 East: Saint Louis
8
Keep slight right to continue on I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
0.3 mi
·
23 sec
·
I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
9
Keep slight left to continue on I 70 East: Saint Louis
1.2 mi
·
1 min
·
I 70 East: Saint Louis
10
Keep slight left to continue on I 70 East: Saint Louis
469 ft
·
12 sec
·
I 70 East: Saint Louis
11
Merge slight left onto George Brett Super Highway
0.4 mi
·
29 sec
·
George Brett Super Highway
12
Continue on Truman/Eisenhower Presidential Highway
2.9 mi
·
3 min
·
Truman/Eisenhower Presidential Highway
13
Continue on Clifton J. Scott Memorial Highway
1.8 mi
·
2 min
·
Clifton J. Scott Memorial Highway
14
Continue on Truman/Eisenhower Presidential Highway
2.6 mi
·
3 min
·
Truman/Eisenhower Presidential Highway
15
Continue on Dwight D. Eisenhower Highway
53 mi
·
56 min
·
Dwight D. Eisenhower Highway
16
Continue on U.S. Submarine Veterans' Memorial Highway
32 mi
·
34 min
·
U.S. Submarine Veterans' Memorial Highway
17
Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway
22 mi
·
24 min
·
U.S. Submarine Veterans' Memorial Highway
18
Continue on Dwight D. Eisenhower Highway
1.8 mi
·
2 min
·
Dwight D. Eisenhower Highway
19
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
·
1 min
·
Highway Patrol Sgt. Benjamin Booth Memorial Highway
20
Continue on Sheriff Roger I. Wilson Memorial Highway
1.9 mi
·
2 min
·
Sheriff Roger I. Wilson Memorial Highway
21
Continue on Dwight D. Eisenhower Highway
81 mi
·
1 hr 35 min
·
Dwight D. Eisenhower Highway
22
Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield
0.3 mi
·
33 sec
·
I 64 East, US 40 East, US 61 South: Chesterfield
23
Merge slight left onto Avenue of the Saints
28 mi
·
33 min
·
Avenue of the Saints
24
Continue on Daniel Boone Expressway
5.7 mi
·
7 min
·
Daniel Boone Expressway
25
Continue on Jack Buck Memorial Highway
5.8 mi
·
7 min
·
Jack Buck Memorial Highway
26
Take the exit slight right toward 14th Street
0.2 mi
·
34 sec
·
14th Street
27
Turn left onto South 14th Street
0.3 mi
·
42 sec
·
South 14th Street
28
Turn right onto Market Street
0.2 mi
·
25 sec
·
Market Street
29
Arrive at your destination
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 170.5 miles from Mound City, MO, or about 2h 38m into the drive.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 75 miles or 1h 9m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 170.5 miles or 2h 38m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 21m
Traffic, exits, and arrival timing usually matter more near St. Louis, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Mound City, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Mound City, MO
This is one driving day of about 340.9 miles and 5h 17m.
Your first comfortable stop window is around 75 miles from Mound City, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 170.5 mi from Mound City, MO · 2h 38m into the drive
Mid-route town
Meal stop
170 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 75 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 170.5 miles from Mound City, MO, which is a good place for a longer meal and fuel stop.
Arriving in St. Louis, MO
The final approach into St. Louis, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around St. Louis, MO.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$53.30 one way
$106.59 round trip
$3.97/gal
25.4 MPG avg
119 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $58.52 | $117.03 |
| premium | $4.89 | $65.60 | $131.21 |
| diesel | $5.61 | $75.27 | $150.53 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$53
Meals
$25–$50
Total
$78–$103
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 119.3 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $36 in charging · 1 stop · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 102.3 | 1 | $35.79 | $16.36 |
| Efficient EV | 85.2 | 0 | $29.83 | $13.64 |
| EV Truck/SUV | 136.4 | 1 | $47.73 | $21.82 |
Gas CO2
119 kg
EV CO2
40 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
St. Louis, MO
Night in St. Louis on Wednesday
Local time
11:21 PM
CDT
Current temp
74°F
Unavailable
Live forecast
74°F
Columbia, MO
170 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 17m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Mound City, MO to St. Louis, MO covers 340.9 miles and takes about 5h 17m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are State Street, I 29 South, I 435 East. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 170.5 miles from Mound City, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $53.30 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a straightforward 5h 17m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
This route does not have any notably tricky sections. Most of the drive from Mound City, MO to St. Louis, MO is straightforward, with well-signed roads and simple exits.
The route from Mound City, MO to St. Louis, MO does not surface many named destination signs beyond the main corridor.
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