The drive from Murphysboro, IL to Markham, IL covers 313.6 miles and takes about 5h 51m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 57, Ken Gray Expressway, IL 149 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 181.3 miles on I 57.
At current regular gas prices, budget about $47.63 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
156.8 miles from Murphysboro, IL
A natural place for your longest stop of the day
, about 3h into the drive
.