Origin
Murrells Inlet, SC
Morning in Murrells Inlet on Monday
Local time
11:32 AM
EDT
Current temp
80°F
Unavailable
Live forecast
Trip from Murrells Inlet, SC to Greenville, SC
Drive Time
4h 24m
Distance
262.9 mi
423 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$42
one way
EV Charging
Loading...
station data
Best Time to Leave
4 AM
4h 11m
★
6 AM
4h 24m
8 AM
4h 51m
10 AM
4h 33m
12 PM
4h 31m
3 PM
4h 35m
5 PM
4h 49m
8 PM
4h 16m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Murrells Inlet, SC
Junior Bastos
Trip Overview
The drive from Murrells Inlet, SC to Greenville, SC covers 262.9 miles and takes about 4h 24m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 17, Wachesaw Road, Highway 17 for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $42.07 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
131.4 miles from Murrells Inlet, SC
A natural place for your longest stop of the day , about 2h 12m into the drive .
Drive Character
Expect a 4h 24m drive with frequent turns across 262.9 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 38 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 17 is one of the defining roads on this drive.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way.
Route Complexity
3/10
Easy - simple navigation with a manageable amount of wheel time
This is a straightforward 4h 24m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
This route does not have any notably tricky sections. Most of the drive from Murrells Inlet, SC to Greenville, SC is straightforward, with well-signed roads and simple exits.
Main Roads
| Road | Distance | Duration |
|---|---|---|
| US 17 | Unavailable | Refreshing |
| Wachesaw Road | Unavailable | Refreshing |
| Highway 17 | Unavailable | Refreshing |
| Ocean Highway | Unavailable | Refreshing |
| L | Unavailable | Refreshing |
| Church Street | Unavailable | Refreshing |
| Highmarket Street | Unavailable | Refreshing |
| Georgetown Highway | Unavailable | Refreshing |
Per-road distance and duration are being refreshed from OSRM for this route.
Longest stretch:
US 17
— detailed segment metrics are refreshing.
Turn-by-Turn Driving Directions
Step-by-step road directions between Murrells Inlet, SC and Greenville, SC.
1
Start on US 17 Business
0.3 mi
·
59 sec
·
US 17 Business
2
Turn right onto Wachesaw Road
0.2 mi
·
36 sec
·
Wachesaw Road
3
Turn left onto Highway 17
1.8 mi
·
2 min
·
Highway 17
4
Continue on Ocean Highway
17 mi
·
25 min
·
Ocean Highway
5
Continue on L. H. Siau Bridge
0.3 mi
·
25 sec
·
L. H. Siau Bridge
6
Continue on Church Street
1.5 mi
·
2 min
·
Church Street
7
Merge slight left onto Highmarket Street
9.4 mi
·
12 min
·
Highmarket Street
8
Continue on Georgetown Highway
6.2 mi
·
7 min
·
Georgetown Highway
9
Continue on Georgetown Highway
1.7 mi
·
2 min
·
Georgetown Highway
10
Continue on East Main Street
1.7 mi
·
2 min
·
East Main Street
11
Continue on US Highway 521
27 mi
·
30 min
·
US Highway 521
12
Continue on Society Street
0.8 mi
·
54 sec
·
Society Street
13
Continue on Society Street
0.5 mi
·
36 sec
·
Society Street
14
Continue on C E Murray Boulevard
12 mi
·
13 min
·
C E Murray Boulevard
15
Turn slight right
338 ft
·
4 sec
16
Keep slight left
0.2 mi
·
15 sec
17
Merge slight left onto Greeleyville Highway
2.4 mi
·
2 min
·
Greeleyville Highway
18
Continue on East Boyce Street
0.4 mi
·
58 sec
·
East Boyce Street
19
Turn right onto North Church Street
0.7 mi
·
49 sec
·
North Church Street
20
Continue on North Brooks Street
15 mi
·
17 min
·
North Brooks Street
21
Turn left onto South Guignard Parkway
1.1 mi
·
1 min
·
South Guignard Parkway
22
Continue on South Guignard Drive
3.6 mi
·
4 min
·
South Guignard Drive
23
Continue on Bultman Drive
0.7 mi
·
1 min
·
Bultman Drive
24
Turn left onto Broad Street
3.3 mi
·
5 min
·
Broad Street
25
Continue straight
34 mi
·
42 min
26
Continue on Devine Street
1.1 mi
·
2 min
·
Devine Street
27
Turn slight right onto Millwood Avenue
1.8 mi
·
4 min
·
Millwood Avenue
28
Turn left onto Taylor Street
0.9 mi
·
1 min
·
Taylor Street
29
Turn right onto Bull Street
0.5 mi
·
1 min
·
Bull Street
30
Turn left onto Elmwood Avenue
0.9 mi
·
2 min
·
Elmwood Avenue
31
Continue straight
3.8 mi
·
4 min
32
Merge slight left
56 mi
·
1 hr 1 min
33
Keep slight left to continue on I 385 North: Laurens, Greenville
30 mi
·
32 min
·
I 385 North: Laurens, Greenville
34
Keep slight left to continue on Golden Strip Freeway
12 mi
·
14 min
·
Golden Strip Freeway
35
Continue on East North Street
0.2 mi
·
19 sec
·
East North Street
36
Continue on Beattie Place
0.2 mi
·
27 sec
·
Beattie Place
37
Turn right onto North Church Street
59 ft
·
2 sec
·
North Church Street
38
Arrive at your destination
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 131.4 miles from Murrells Inlet, SC, or about 2h 12m into the drive.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 20m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 131.4 miles or 2h 12m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 36m
Traffic, exits, and arrival timing usually matter more near Greenville, SC than in the middle of the route.
Before You Leave
+
Open the route before leaving Murrells Inlet, SC so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Murrells Inlet, SC
This is one driving day of about 262.9 miles and 4h 24m.
Your first comfortable stop window is around 80 miles from Murrells Inlet, SC.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 131.4 mi from Murrells Inlet, SC · 2h 12m into the drive
Mid-route town
Meal stop
131 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 80 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 131.4 miles from Murrells Inlet, SC, which is a good place for a longer meal and fuel stop.
Arriving in Greenville, SC
The final approach into Greenville, SC usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Greenville, SC.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$42.07 one way
$84.15 round trip
$4.07/gal
25.4 MPG avg
92 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.43 | $45.84 | $91.68 |
| premium | $4.78 | $49.45 | $98.91 |
| diesel | $5.64 | $58.41 | $116.81 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$42
Meals
$25–$50
Total
$67–$92
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 92 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $28 in charging · 0 stops · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 78.9 | 0 | $27.60 | $12.62 |
| Efficient EV | 65.7 | 0 | $23.00 | $10.52 |
| EV Truck/SUV | 105.2 | 1 | $36.81 | $16.83 |
Gas CO2
92 kg
EV CO2
31 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Greenville, SC
Morning in Greenville on Monday
Local time
11:32 AM
EDT
Current temp
63°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
17 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 24m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Murrells Inlet, SC to Greenville, SC covers 262.9 miles and takes about 4h 24m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 17, Wachesaw Road, Highway 17. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 131.4 miles from Murrells Inlet, SC. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $42.07 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a straightforward 4h 24m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
This route does not have any notably tricky sections. Most of the drive from Murrells Inlet, SC to Greenville, SC is straightforward, with well-signed roads and simple exits.
The route from Murrells Inlet, SC to Greenville, SC does not surface many named destination signs beyond the main corridor.
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