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Trip from North Myrtle Beach, SC to Greenville, SC

Drive Time

5h 4m

Distance

259 mi

417 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$41

one way

EV Charging

Excellent

26 DC fast

Best Time to Leave

Save up to 41 min
4 AM
4h 51m ★
6 AM
5h 5m
8 AM
5h 32m
10 AM
5h 14m
12 PM
5h 11m
3 PM
5h 15m
5 PM
5h 30m
8 PM
4h 57m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly
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city in Horry County, South Carolina, United States of America

North Myrtle Beach, SC

Wikimedia Commons

Trip Overview

The drive from North Myrtle Beach, SC to Greenville, SC covers 259 miles and takes about 5h 4m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on J Strom Thurmond Freeway, I 26, I 385 for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 76.4 miles on J Strom Thurmond Freeway. At current regular gas prices, budget about $41.45 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

129.5 miles from North Myrtle Beach, SC

A natural place for your longest stop of the day , about 2h 38m into the drive .

Drive Character

This is a 5h 4m highway drive covering 259 miles, with most of the trip on J Strom Thurmond Freeway and I 26. The longest continuous stretch is about 76.4 miles on J Strom Thurmond Freeway.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 26 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
J Strom Thurmond Freeway is the longest continuous segment at about 76.4 miles.

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on J Strom Thurmond Freeway and I 26. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 2.9 miles in.

Route Complexity 9/10

High effort - long or complex enough to need steady focus all day

This is a demanding drive. With 18 significant decision points across 259 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 2.9 miles: Multiple destination signs - pick the right one; at 7.7 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 34.7 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one.

Critical Maneuvers

5 of 18 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

6
2.9 mi into trip | ~5m in

Turn left toward SC 31 South: US 501, Myrtle Beach

Multiple destination signs - pick the right one

Toward SC 31 South: US 501, Myrtle Beach
5
7.7 mi into trip | ~11m in

Take the exit toward SC 22: Myrtle Beach, Conway

Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one

Toward SC 22: Myrtle Beach, Conway
6
34.7 mi into trip | ~44m in

Keep slight right at fork toward US 501 North: Aynor, Marion

Highway fork - watch signs carefully. Multiple destination signs - pick the right one

Toward US 501 North: Aynor, Marion
9
216.5 mi into trip | ~4h 16m in | I 385

Keep slight left at fork onto I 385 toward I 385 North: Laurens, Greenville

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left / straight lanes. Exit 51 Toward I 385 North: Laurens, Greenville
6
246.1 mi into trip | ~4h 48m in | I 385 / Golden Strip Freeway

Keep slight left at fork onto I 385 / Golden Strip Freeway

Highway fork - watch signs carefully. Lane positioning matters here

Use the straight / slight right lanes.

Towns Along This Route

On the drive from North Myrtle Beach, SC to Greenville, SC, road signs begin pointing toward Marion along the way.

Marion

34.7 mi in | ~44m

Main Roads

Road Distance Duration
J Strom Thurmond Freeway 76.4 mi 1h 25m
I 26 54.8 mi 1h
I 385 29.6 mi 32m
Veterans Highway 25.9 mi 30m
US 501 21 mi 24m
US 76 18.8 mi 24m
Golden Strip Freeway 12.4 mi 14m
Carolina Bays Parkway 4.4 mi 5m
Longest stretch: J Strom Thurmond Freeway — 76.4 mi, about 1h 25m

Turn-by-Turn Driving Directions

Step-by-step road directions between North Myrtle Beach, SC and Greenville, SC.

1

Start on S-26-358

0.7 mi · 1 min · 6th Avenue South
2

Turn right onto US 17

0.3 mi · 40 sec · US Highway 17 South
3

Turn left onto Robert Edge Parkway

1.9 mi · 3 min · Robert Edge Parkway
Use the left lane.
4

Turn left

0.3 mi · 42 sec
Toward SC 31 South: US 501, Myrtle Beach
5

Merge onto SC 31

4.4 mi · 5 min · Carolina Bays Parkway
6

Take the exit

0.4 mi · 56 sec
Toward SC 22: Myrtle Beach, Conway
7

Keep slight right at fork

0.7 mi · 1 min
Toward SC 22 West: Conway
8

Merge onto SC 22

26 mi · 30 min · Veterans Highway
9

Keep slight right at fork

0.2 mi · 23 sec
Toward US 501 North: Aynor, Marion
10

Merge onto US 501

21 mi · 24 min · US 501
11

Turn straight onto SC 576

3.2 mi · 3 min · SC 576
12

Continue on US 76

6.7 mi · 7 min · US 76
Use the straight lane.
13

Continue on US 76; US 301

12 mi · 16 min · US 76; US 301
Use the straight lane.
14

Turn slight right onto East Cheves Street

1.7 mi · 3 min · East Cheves Street
15

Turn right onto Warley Street

0.1 mi · 18 sec · Warley Street
16

Turn left onto S-21-31

2.4 mi · 4 min · West Evans Street
17

Turn right onto I 20 Bus

1.5 mi · 2 min · West David H McLeod Boulevard
18

Continue on I 20 Bus

76 mi · 1 hr 25 min · J Strom Thurmond Freeway
Use the straight / slight right lanes.
19

Take the exit

1.7 mi · 3 min
Exit 64B Toward I 26 West
20

Merge onto I 26; US 76

55 mi · 1 hr · I 26; US 76
Use the straight / slight right lanes.
21

Keep slight left at fork onto I 385

30 mi · 32 min · I 385
Exit 51 Toward I 385 North: Laurens, Greenville Use the slight left / straight lanes.
22

Keep slight left at fork onto I 385

12 mi · 14 min · Golden Strip Freeway
Use the straight / slight right lanes.
23

Continue on East North Street

0.2 mi · 18 sec · East North Street
24

Continue on SC 183

0.2 mi · 26 sec · Beattie Place
Use the left / straight / right lanes.
25

Turn right onto US 29

60 ft · 1 sec · North Church Street
26

Arrive at destination

US 29

Trip Plan

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 129.5 miles from North Myrtle Beach, SC, or about 2h 38m into the drive.
The longest continuous stretch on this route runs about 76.4 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 40m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 129.5 miles or 2h 38m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 4h 12m

Traffic, exits, and arrival timing usually matter more near Greenville, SC than in the middle of the route.

Before You Leave

+

Open the route before leaving North Myrtle Beach, SC so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from North Myrtle Beach, SC

This is one driving day of about 259 miles and 5h 4m.

Your first comfortable stop window is around 80 miles from North Myrtle Beach, SC.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on J Strom Thurmond Freeway for about 76.4 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 129.5 mi from North Myrtle Beach, SC · 2h 38m into the drive

Downtown Charlotte, NC, NC

Mid-route town

Meal stop

Charlotte, NC

130 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Fayetteville, NC

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Charlotte, NC

Meal break

The midpoint is around 129.5 miles from North Myrtle Beach, SC, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before J Strom Thurmond Freeway if your tank is already low. That segment runs about 76.4 miles.

Arriving in Greenville, SC

The final approach into Greenville, SC usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Greenville, SC.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

National Parks Near This Route

Worth a detour if your schedule allows.

Congaree National Park

Congaree National Park

National Park

Astonishing biodiversity exists in Congaree National Park, the largest intact expanse of old growth bottomland hardwood forest remaining in the southeastern United States. Waters from the Congaree and...

22 mi from route ~56 min detour Free near mile 142.9
Caution: Backcountry Trail Conditions
Park Closure: Boardwalk Partially Closed for Construction
View on nps.gov

Park data from the National Park Service API. Alerts update every 2 hours.

Fuel & Cost

Regular Gas

$41.45 one way

$82.90 round trip

$4.07/gal 25.4 MPG avg 91 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.43 $45.16 $90.32
premium $4.78 $48.72 $97.44
diesel $5.64 $57.54 $115.08

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$41

Meals

$25–$50

Total

$66–$91

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 90.6 kg one way. Prices: EIA weekly data, 2026-04-06.

EV Charging Along Route

26 DC fast chargers · Coverage: excellent

Magnolia Mall - Tesla Supercharger

Florence, SC

Tesla

18 DCFC

Refuel Market - Tesla Supercharger

Bishopville, SC

Tesla

12 DCFC

Village at Sandhill - Tesla Supercharger

Columbia, SC

Tesla

12 DCFC

Lowes Foods of Forest Acres - Tesla Supercharger

Columbia, SC

Tesla

11 DCFC

Barefoot Landing - Tesla Supercharger

North Myrtle Beach, SC

Tesla

8 DCFC

Florence, SC Rechargery Relay - David H McLeod Blvd

Florence, SC

IONNA

8 DCFC

Hilton Garden Inn Columbia Northeast - Tesla Supercharger

Columbia, SC

Tesla

8 DCFC

Cracker Barrel - Tesla Supercharger

Columbia, SC

Tesla

8 DCFC

Tesla: 7 ChargePoint Network: 5 Non-Networked: 4 EV Connect: 3 CIRCLE_K: 2 Electrify America: 2 IONNA: 1 FORD_CHARGE: 1 eVgo Network: 1

Station data from NREL Alternative Fuel Stations database.

Driving Electric?

About $27 in charging · 0 stops · 67% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 77.7 0 $27.20 $12.43
Efficient EV 64.8 0 $22.66 $10.36
EV Truck/SUV 103.6 1 $36.26 $16.58

Gas CO2

91 kg

EV CO2

30 kg (67% less)

Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 15 hours ago

Origin

North Myrtle Beach, SC

Afternoon in North Myrtle Beach on Monday

Local time

3:08 PM

EDT

Current temp

75°F

Unavailable

Live forecast

Destination

Greenville, SC

Afternoon in Greenville on Monday

Local time

3:08 PM

EDT

Current temp

63°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

12 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

5h 4m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from North Myrtle Beach, SC to Greenville, SC covers 259 miles and takes about 5h 4m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are J Strom Thurmond Freeway, I 26, I 385. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 129.5 miles from North Myrtle Beach, SC. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $41.45 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 18 significant decision points across 259 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 2.9 miles: Multiple destination signs - pick the right one; at 7.7 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 34.7 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
On the drive from North Myrtle Beach, SC to Greenville, SC, road signs begin pointing toward Marion along the way.

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