The drive from Myrtle Beach, SC to Brookdale, SC covers 141 miles and takes about 3h 2m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 95, East Myrtle Beach Highway, Highway 378 for much of the mileage,
and the overall profile is mixed drive.
The longest uninterrupted segment is about 38.1 miles on I 95.
At current regular gas prices, budget about $22.05 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
70.5 miles from Myrtle Beach, SC
A natural place for your longest stop of the day
, about 1h 37m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 3h 2m. Total distance: 141 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 2m drive, comfortable solo distance.
Scenic Drive
Mixed drive route profile with national parks nearby.
Drive Character
The drive from Myrtle Beach, SC to Brookdale, SC covers 141 miles and takes about 3h 2m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 29 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 95 is the longest continuous segment at about 38.1 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near US 17 Business / North Kings Highway.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 141 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (US 17 Business / North Kings Highway): Navigation decision point; at 0.4 miles (Alder Street): Navigation decision point; at 79.6 miles: Exit ramp - move to the correct lane early.
Critical Maneuvers
5 of 17 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
0 mi into trip|~0m in|US 17 Business / North Kings Highway
At end of road, turn right onto US 17 Business / North Kings Highway
Navigation decision point
5
0.4 mi into trip|~1m in|Alder Street
At end of road, turn right onto Alder Street
Navigation decision point
6
79.6 mi into trip|~1h 49m in
Take the exit toward I 95 South: Savannah
Exit ramp - move to the correct lane early
Toward I 95 South: Savannah
6
138.5 mi into trip|~2h 56m in
Take the exit toward SC 33: Orangeburg, Cameron
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 149
Toward SC 33: Orangeburg, Cameron
7
138.7 mi into trip|~2h 56m in
Keep slight right at fork toward SC 33: Orangeburg
Highway fork - watch signs carefully
Exit 149
Toward SC 33: Orangeburg
Main Roads
Road
Distance
Duration
I 95
38.1 mi
40m
East Myrtle Beach Highway
36.1 mi
43m
Highway 378
22.9 mi
32m
Five Chop Road
14.3 mi
17m
US 501
10.5 mi
16m
I 26
5.4 mi
5m
Clarence Coker Highway
3.5 mi
4m
Highway 501 East
2 mi
3m
Longest stretch:
I 95
— 38.1 mi, about 40m
Turn-by-Turn Driving Directions
Step-by-step road directions between Myrtle Beach, SC and Brookdale, SC.
1
Start on this road
69 ft·9 sec·this road
2
Turn left
159 ft·13 sec
3
At end of road, turn right onto US 17 Business
0.1 mi·20 sec·North Kings Highway
4
Turn left onto 6th Avenue North
489 ft·21 sec·6th Avenue North
5
Continue on 6th Avenue North
0.2 mi·46 sec·6th Avenue North
6
At end of road, turn right onto Alder Street
154 ft·6 sec·Alder Street
7
Turn left onto US 501
11 mi·16 min·US 501
Use the straight / right lanes.
8
Continue on US 501
2.0 mi·3 min·Highway 501 East
9
Continue on US 501
1.5 mi·2 min·Church Street
10
Turn left onto US 378
1.1 mi·2 min·Wright Boulevard
11
Continue on US 378
23 mi·32 min·Highway 378
12
Continue on US 378
36 mi·43 min·East Myrtle Beach Highway
13
Continue on US 301; US 378
0.5 mi·1 min·Main Street
14
Turn slight right onto Clarence Coker Highway
3.5 mi·4 min·Clarence Coker Highway
15
Continue on US 378
1.1 mi·1 min·Myrtle Beach Highway
16
Take the exit
0.3 mi·40 sec
Toward I 95 South: Savannah
17
Merge onto I 95
38 mi·40 min·I 95
18
Take the exit
0.4 mi·46 sec
Toward US 301: Orangeburg
19
Keep slight right at fork
325 ft·8 sec
20
Merge onto US 15; US 301
14 mi·17 min·Five Chop Road
21
Take the exit
0.3 mi·42 sec
22
Merge onto I 26
5.4 mi·5 min·I 26
23
Take the exit
0.2 mi·22 sec
Exit 149Toward SC 33: Orangeburg, Cameron
24
Keep slight right at fork
0.1 mi·14 sec
Exit 149Toward SC 33: Orangeburg
25
Turn straight onto SC 33
1.8 mi·3 min·Russell Street
26
Turn right onto Old Cameron Road
0.1 mi·29 sec·Old Cameron Road
27
Turn right onto Shadow Lawn Drive
0.2 mi·1 min·Shadow Lawn Drive
28
Turn left onto Dellwood Drive
424 ft·18 sec·Dellwood Drive
29
Arrive at destination
Dellwood Drive
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 70.5 miles from Myrtle Beach, SC, or about 1h 37m into the drive.
The longest continuous stretch on this route runs about 38.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 31 miles or 48m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 70.5 miles or 1h 37m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 28m
Traffic, exits, and arrival timing usually matter more near Brookdale, SC than in the middle of the route.
Before You Leave
+
Open the route before leaving Myrtle Beach, SC so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Myrtle Beach, SC
This is one driving day of about 141 miles and 3h 2m.
Your first comfortable stop window is around 31 miles from Myrtle Beach, SC.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 95 for about 38.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 70.5 mi from Myrtle Beach, SC
· 1h 37m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Congaree National Park
National Park
Astonishing biodiversity exists in Congaree National Park, the largest intact expanse of old growth bottomland hardwood forest remaining in the southeastern United States. Waters from the Congaree and...
20 mi from route
~50 min detour
Free
near mile 141
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $15 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
42.3
0
$14.80
$6.77
Efficient EV
35.3
0
$12.34
$5.64
EV Truck/SUV
56.4
0
$19.74
$9.02
Gas CO2
49 kg
EV CO2
16 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Myrtle Beach, SC
Afternoon
in Myrtle Beach on Friday
Local time
2:06 PM
EDT
Current temp
58°F
Unavailable
Live forecast
Destination
Brookdale, SC
Afternoon
in Brookdale on Friday
Local time
2:06 PM
EDT
Current temp
49°F
Unavailable
Live forecast
74°F
Lake City, SC
71 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
9 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 2m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Myrtle Beach, SC to Brookdale, SC covers 141 miles and takes about 3h 2m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 95, East Myrtle Beach Highway, Highway 378. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 70.5 miles from Myrtle Beach, SC. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $22.05 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
This is a demanding drive. With 17 significant decision points across 141 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: near the start (US 17 Business / North Kings Highway): Navigation decision point; at 0.4 miles (Alder Street): Navigation decision point; at 79.6 miles: Exit ramp - move to the correct lane early.
The route from Myrtle Beach, SC to Brookdale, SC does not surface many named destination signs beyond the main corridor.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
