Drive Time
5h 37m
Distance
275.7 mi
444 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$44
one way
Photo: Kelly
The drive from Myrtle Beach, SC to Clemson, SC covers 275.7 miles and takes about 5h 37m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on North Kings Highway, 6th Avenue North, Alder Street for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $44.12 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
137.9 miles from Myrtle Beach, SC
A natural place for your longest stop of the day , about 2h 48m into the drive .
Expect a 5h 37m drive with frequent turns across 275.7 miles of local and secondary roads.
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way.
Easy - simple navigation with a manageable amount of wheel time
This is a straightforward 5h 37m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
This route does not have any notably tricky sections. Most of the drive from Myrtle Beach, SC to Clemson, SC is straightforward, with well-signed roads and simple exits.
| Road | Distance | Duration |
|---|---|---|
| North Kings Highway | Unavailable | Refreshing |
| 6th Avenue North | Unavailable | Refreshing |
| Alder Street | Unavailable | Refreshing |
| Highway 501 East | Unavailable | Refreshing |
| Church Street | Unavailable | Refreshing |
| East Cheves Street | Unavailable | Refreshing |
| Warley Street | Unavailable | Refreshing |
| West Evans Street | Unavailable | Refreshing |
Per-road distance and duration are being refreshed from OSRM for this route.
Step-by-step road directions between Myrtle Beach, SC and Clemson, SC.
Start on the route
Turn left
At the end of the road, turn right onto North Kings Highway
Turn left onto 6th Avenue North
Continue on 6th Avenue North
At the end of the road, turn right onto Alder Street
Turn left
Continue on Highway 501 East
Continue on Church Street
Turn straight
Continue straight
Continue straight
Turn slight right onto East Cheves Street
Turn right onto Warley Street
Turn left onto West Evans Street
Turn right onto West David H McLeod Boulevard
Continue on J Strom Thurmond Freeway
Take the exit slight right toward I 26 West
Merge slight left
Keep slight left to continue on I 385 North: Laurens, Greenville
Keep slight right to continue on I 185, US 276: Atlanta, Mauldin, Anderson
Take the exit slight left toward I 185: Atlanta, Anderson
Merge slight left onto Southern Connector
Take the exit slight right toward Easley, Clemson
Keep slight right to continue on Easley, Clemson
Merge slight left onto Highway 153
Enter the roundabout and take exit 1 toward the route
Exit the roundabout
Merge slight left onto Calhoun Memorial Highway
Continue on Tiger Boulevard
Turn left onto College Avenue
Arrive at your destination
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 37m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 137.9 miles or 2h 48m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 36m
Traffic, exits, and arrival timing usually matter more near Clemson, SC than in the middle of the route.
Open the route before leaving Myrtle Beach, SC so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Myrtle Beach, SC
This is one driving day of about 275.7 miles and 5h 37m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 137.9 mi from Myrtle Beach, SC · 2h 48m into the drive
Mid-route town
Meal stop
138 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 137.9 miles from Myrtle Beach, SC, which is a good place for a longer meal and fuel stop.
The final approach into Clemson, SC usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Clemson, SC.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$44.12 one way
$88.25 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.43 | $48.07 | $96.15 |
| premium | $4.78 | $51.86 | $103.72 |
| diesel | $5.64 | $61.25 | $122.50 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$44
Meals
$25–$50
Total
$69–$94
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 96.5 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $29 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 82.7 | 1 | $28.95 | $13.23 |
| Efficient EV | 68.9 | 0 | $24.12 | $11.03 |
| EV Truck/SUV | 110.3 | 1 | $38.60 | $17.64 |
Gas CO2
96 kg
EV CO2
32 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Afternoon in Myrtle Beach on Saturday
Local time
4:20 PM
EDT
Current temp
65°F
Forecast unavailable right now
Destination
Afternoon in Clemson on Saturday
Local time
4:20 PM
EDT
Current temp
64°F
Forecast unavailable right now
Along the Route
65°F
Charlotte, NC
138 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
An early start around 7-8 AM gets you there with plenty of daylight left.
Thanks for your feedback!
Your tip has been submitted. Thanks!
/500
Recent Tips
·
Explore more options from Myrtle Beach, SC or browse trips ending in Clemson, SC.
Looking for more statewide routes? Browse SC road trips.
Explore maps for Myrtle Beach, SC or Clemson, SC on MapSof.net.
