Trip from New York, MO to Doniphan, MO

Drive Time

7h 54m

Distance

376.3 mi

606 km

Drive Score

10/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$57

one way

EV Charging

None

0 DC fast

Best Time to Leave

Save up to 27 min
4 AM
7h 45m ★
6 AM
7h 54m
8 AM
8h 12m
10 AM
8h 0m
12 PM
7h 59m
3 PM
8h 1m
5 PM
8h 11m
8 PM
7h 49m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Downtown New York, MO, MO

New York, MO

Ian Ramírez

Downtown Doniphan, MO, MO

Doniphan, MO

Lena Khrupina

Trip Overview

The drive from New York, MO to Doniphan, MO covers 376.3 miles and takes about 7h 54m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on North Missouri Street, Chicago-Kansas City Expressway, US 63 for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 86.2 miles on North Missouri Street. At current regular gas prices, budget about $57.16 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

2 planned breaks

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

188.1 miles from New York, MO

A natural place for your longest stop of the day , about 3h 40m into the drive .

Drive Character

This is a 7h 54m highway drive covering 376.3 miles, with most of the trip on North Missouri Street and Chicago-Kansas City Expressway. The longest continuous stretch is about 86.2 miles on North Missouri Street.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 23 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
North Missouri Street is the longest continuous segment at about 86.2 miles.

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on North Missouri Street and Chicago-Kansas City Expressway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 170.8 miles in near US 63.

Route Complexity 8/10

Demanding - plan breaks and stay ahead of the key maneuvers

This is a demanding drive. With 18 significant decision points across 376.3 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 170.8 miles (US 63): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 171 miles (US 63): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 183.1 miles (US 63): Highway fork - watch signs carefully. Lane positioning matters here.

Critical Maneuvers

5 of 18 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

7
170.8 mi into trip | ~3h 18m in | US 63

Keep slight left at fork onto US 63 toward US 63 South, US 50

Highway fork - watch signs carefully. Multiple destination signs - pick the right one

Toward US 63 South, US 50
9
171 mi into trip | ~3h 18m in | US 63

Keep slight left at fork onto US 63 toward US 63 South, US 50 East

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left lane. Toward US 63 South, US 50 East
7
183.1 mi into trip | ~3h 34m in | US 63

Keep slight right at fork onto US 63 toward US 63 South: Rolla

Highway fork - watch signs carefully. Lane positioning matters here

Use the straight lane. Toward US 63 South: Rolla
6
232.5 mi into trip | ~4h 37m in | North Walnut Street

Turn left onto North Walnut Street

Lane positioning matters here

Use the left lane.
6
234.4 mi into trip | ~4h 43m in | MO 72

Turn left onto MO 72

Lane positioning matters here

Use the left lane.

Towns Along This Route

On the drive from New York, MO to Doniphan, MO, road signs begin pointing toward Macon along the way.

Macon

83 mi in | ~1h 40m

Main Roads

Road Distance Duration
North Missouri Street 86.2 mi 1h 35m
Chicago-Kansas City Expressway 79.5 mi 1h 31m
US 63 63.2 mi 1h 21m
South Main Street 54.4 mi 1h 15m
US 60 36.6 mi 42m
MO 72 24.3 mi 31m
MO 21 24.3 mi 36m
MO B 3.5 mi 8m
Longest stretch: North Missouri Street — 86.2 mi, about 1h 35m

Turn-by-Turn Driving Directions

Step-by-step road directions between New York, MO and Doniphan, MO.

1

Start on MO B

3.5 mi · 8 min · MO B
2

Turn right onto US 36; MO 110

80 mi · 1 hr 31 min · Chicago-Kansas City Expressway
3

Take the exit

0.2 mi · 25 sec
Toward US 63: Kirksville, Macon
4

Turn right onto US 63

86 mi · 1 hr 35 min · North Missouri Street
5

Take the exit onto US 63

1.5 mi · 2 min · US 63
Toward US 54 West, US 63 South: Jefferson City
6

Take the exit onto US 63

217 ft · 4 sec · US 63
Toward US 63 South, US 50
7

Keep slight left at fork onto US 63

0.1 mi · 16 sec · US 63
Toward US 63 South, US 50
8

Keep slight left at fork onto US 63

0.1 mi · 15 sec · US 63
Toward US 63 South, US 50 East Use the slight left lane.
9

Keep slight left at fork onto US 63

12 mi · 14 min · US 63
10

Keep slight right at fork onto US 63

49 mi · 1 hr 3 min · US 63
Toward US 63 South: Rolla Use the straight lane.
11

Turn left onto North Walnut Street

0.1 mi · 25 sec · North Walnut Street
Use the left lane.
12

Continue on East 18th Street

0.2 mi · 38 sec · East 18th Street
13

Turn right onto Holloway Street

0.9 mi · 2 min · Holloway Street
Use the straight / right lanes.
14

At end of road, turn left onto Salem Avenue

0.7 mi · 1 min · Salem Avenue
15

Turn left onto MO 72

2.3 mi · 3 min · MO 72
Use the left lane.
16

Continue on MO 72

22 mi · 27 min · MO 72
Use the straight lane.
17

At end of road, turn left onto MO 32; MO 72

1.5 mi · 2 min · MO 32; MO 72
Use the left lane.
18

Turn right onto MO 19

54 mi · 1 hr 15 min · South Main Street
19

Turn left onto US 60

37 mi · 42 min · US 60
20

Turn right onto MO 21

24 mi · 36 min · MO 21
21

Turn left onto MO 142

0.7 mi · 1 min · Walnut Street
22

Turn left onto Plum Street

169 ft · 7 sec · Plum Street
23

Arrive at destination

Plum Street

Trip Plan

Morning Departure

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Evening Departure

This is a long drive — plan for a morning departure or consider splitting it into two days.

You can normally do this drive in one day.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 188.1 miles from New York, MO, or about 3h 40m into the drive.
The longest continuous stretch on this route runs about 86.2 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 83 miles or 1h 40m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 188.1 miles or 3h 40m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 6h 35m

Traffic, exits, and arrival timing usually matter more near Doniphan, MO than in the middle of the route.

Before You Leave

+

Open the route before leaving New York, MO so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

+

Pick one backup stop option before the midpoint in case traffic changes your pacing.

Day 1

Settle into the route from New York, MO

This is one driving day of about 376.3 miles and 7h 54m.

Your first comfortable stop window is around 83 miles from New York, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on North Missouri Street for about 86.2 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 188.1 mi from New York, MO · 3h 40m into the drive

Downtown Cahokia, IL, IL

Mid-route town

Meal stop

Cahokia, IL

188 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Quincy, IL

Fuel and coffee

A short stop after about 83 miles helps settle the day before fatigue starts building.

Quincy, IL

Meal break

The midpoint is around 188.1 miles from New York, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before North Missouri Street if your tank is already low. That segment runs about 86.2 miles.

Arriving in Doniphan, MO

The final approach into Doniphan, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Doniphan, MO.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$57.16 one way

$114.31 round trip

$3.86/gal 25.4 MPG avg 132 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.25 $63.01 $126.02
premium $4.80 $71.04 $142.08
diesel $5.64 $83.60 $167.20

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$57

Meals

$25–$50

Total

$82–$107

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 131.7 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $40 in charging · 1 stop · 67% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 112.9 1 $39.51 $18.06
Efficient EV 94.1 1 $32.93 $15.05
EV Truck/SUV 150.5 1 $52.68 $24.08

Gas CO2

132 kg

EV CO2

44 kg (67% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 4 days ago

Origin

New York, MO

Morning in New York on Monday

Local time

7:20 AM

CDT

Current temp

69°F

Unavailable

Live forecast

Destination

Doniphan, MO

Morning in Doniphan on Monday

Local time

7:20 AM

CDT

Current temp

62°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

7 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

7h 54m on the road

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from New York, MO to Doniphan, MO covers 376.3 miles and takes about 7h 54m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are North Missouri Street, Chicago-Kansas City Expressway, US 63. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 188.1 miles from New York, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $57.16 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 2 meaningful breaks for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 18 significant decision points across 376.3 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 170.8 miles (US 63): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 171 miles (US 63): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 183.1 miles (US 63): Highway fork - watch signs carefully. Lane positioning matters here.
On the drive from New York, MO to Doniphan, MO, road signs begin pointing toward Macon along the way.

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