The drive from Odessa, MO to St. Louis, MO covers 213.2 miles and takes about 4h 7m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Avenue of the Saints for much of the mileage,
and the overall profile is turn-heavy local drive.
The longest uninterrupted segment is about 113.7 miles on Dwight D. Eisenhower Highway.
At current regular gas prices, budget about $33.33 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
106.6 miles from Odessa, MO
A natural place for your longest stop of the day
, about 1h 58m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 7m. Total distance: 213.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 7m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (3%). Some complex stretches to watch for.
Scenic Drive
Turn-heavy local drive route profile with national parks nearby.
Drive Character
Expect a 4h 7m drive with frequent turns across 213.2 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 19 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D. Eisenhower Highway is the longest continuous segment at about 113.7 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 10 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near MO 131 / South 2nd Street.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 213.2 miles you will encounter 10 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (MO 131 / South 2nd Street): Navigation decision point; at 173 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 173.3 miles (I 64; US 40; US 61 / Avenue of the Saints): Merge point - match speed before joining. Lane positioning matters here.
Critical Maneuvers
5 of 10 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
4
0 mi into trip|~0m in|MO 131 / South 2nd Street
Turn right onto MO 131 / South 2nd Street
Navigation decision point
6
173 mi into trip|~3h 16m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
5
173.3 mi into trip|~3h 17m in|I 64; US 40; US 61 / Avenue of the Saints
Merge onto I 64; US 40; US 61 / Avenue of the Saints
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight left lanes.
7
212.4 mi into trip|~4h 5m in
Take the exit toward 14th Street
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 39A
Toward 14th Street
5
212.7 mi into trip|~4h 6m in|South 14th Street
Turn left onto South 14th Street
Lane positioning matters here
Use the left lane.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
113.7 mi
2h 10m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Avenue of the Saints
27.7 mi
33m
Jack Buck Memorial Highway
5.8 mi
7m
Daniel Boone Expressway
5.7 mi
7m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
1m
West Old U.S. 40
0.6 mi
1m
Longest stretch:
Dwight D. Eisenhower Highway
— 113.7 mi, about 2h 10m
Turn-by-Turn Driving Directions
Step-by-step road directions between Odessa, MO and St. Louis, MO.
1
Start on West Mason Street
31 ft·5 sec·West Mason Street
2
Turn right onto MO 131
0.5 mi·1 min·South 2nd Street
3
At end of road, turn right onto West Old U.S. 40
0.6 mi·1 min·West Old U.S. 40
4
Take the ramp
0.2 mi·26 sec
Toward I 70 East, US 40 East: Columbia
5
Merge onto I 70; US 40
31 mi·33 min·Dwight D. Eisenhower Highway
6
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
7
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
8
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
9
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
10
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
11
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
12
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
13
Merge onto I 64; US 40; US 61
28 mi·33 min·Avenue of the Saints
Use the straight / slight left lanes.
14
Continue on I 64; US 40
5.7 mi·7 min·Daniel Boone Expressway
Use the straight lane.
15
Continue on I 64; US 40
5.8 mi·7 min·Jack Buck Memorial Highway
Use the straight / slight right lanes.
16
Take the exit
0.2 mi·34 sec
Exit 39AToward 14th StreetUse the slight right lane.
17
Turn left onto South 14th Street
0.3 mi·42 sec·South 14th Street
Use the left lane.
18
Turn right onto Market Street
0.2 mi·25 sec·Market Street
19
Arrive at destination
Market Street
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 106.6 miles from Odessa, MO, or about 1h 58m into the drive.
The longest continuous stretch on this route runs about 113.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 47 miles or 52m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 106.6 miles or 1h 58m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 19m
Traffic, exits, and arrival timing usually matter more near St. Louis, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Odessa, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Odessa, MO
This is one driving day of about 213.2 miles and 4h 7m.
Your first comfortable stop window is around 47 miles from Odessa, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 113.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 106.6 mi from Odessa, MO
· 1h 58m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $22 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
64
0
$22.39
$10.23
Efficient EV
53.3
0
$18.65
$8.53
EV Truck/SUV
85.3
1
$29.85
$13.64
Gas CO2
75 kg
EV CO2
25 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Odessa, MO
Morning
in Odessa on Friday
Local time
6:28 AM
CDT
Current temp
72°F
Unavailable
Live forecast
Destination
St. Louis, MO
Morning
in St. Louis on Friday
Local time
6:28 AM
CDT
Current temp
74°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 7m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Odessa, MO to St. Louis, MO covers 213.2 miles and takes about 4h 7m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Avenue of the Saints. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 106.6 miles from Odessa, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $33.33 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This drive requires moderate attention. Across 213.2 miles you will encounter 10 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: near the start (MO 131 / South 2nd Street): Navigation decision point; at 173 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 173.3 miles (I 64; US 40; US 61 / Avenue of the Saints): Merge point - match speed before joining. Lane positioning matters here.
The route from Odessa, MO to St. Louis, MO does not surface many named destination signs beyond the main corridor.
Yes. Nearby national parks include Gateway Arch National Park.
How this page is built
Compiled and maintained by the Trip.ovh planning team at COD Solutions Oy (Helsinki). Each route is built from authoritative open government and mapping datasets rather than crowdsourced reviews. Distances and geometry come from
OSRM
over
OpenStreetMap.
Fuel cost uses
EIA
weekly regional averages.
EV charging comes from the
NREL Alternative Fuels
dataset.
National park proximity is from the
NPS API.
Pages are published only after passing our data-quality checks; our
methodology page
documents refresh cadence, editorial standards, and known limitations.
