The drive from O'Fallon, MO to Glendale, MO covers 214.9 miles and takes about 4h 18m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Police Officer Steven Jarvis Memorial Highway, I 270, I 70 for much of the mileage,
and the overall profile is turn-heavy local drive.
The longest uninterrupted segment is about 160.1 miles on Police Officer Steven Jarvis Memorial Highway.
At current regular gas prices, budget about $33.60 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
107.5 miles from O'Fallon, MO
A natural place for your longest stop of the day
, about 2h 3m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 18m. Total distance: 214.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 18m drive, comfortable solo distance.
Scenic Drive
Turn-heavy local drive route profile with national parks nearby.
Drive Character
Expect a 4h 18m drive with frequent turns across 214.9 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 23 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Police Officer Steven Jarvis Memorial Highway is the longest continuous segment at about 160.1 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.6 miles in near Drennen Parkway.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 214.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.6 miles (Drennen Parkway): Lane positioning matters here; at 1.5 miles: Lane positioning matters here; at 15.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 17 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
0.6 mi into trip|~1m in|Drennen Parkway
Turn left onto Drennen Parkway
Lane positioning matters here
Use the left lane.
5
1.5 mi into trip|~3m in
Take the ramp toward I 70 East: Saint Louis
Lane positioning matters here
Use the slight left lane.
Toward I 70 East: Saint Louis
8
15.1 mi into trip|~20m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 232
Toward I 270: Chicago, Memphis
7
15.2 mi into trip|~20m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
34.8 mi into trip|~44m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from O'Fallon, MO to Glendale, MO, road signs begin pointing toward Memphis along the way.
Memphis
15.1 mi in|~20m
Main Roads
Road
Distance
Duration
Police Officer Steven Jarvis Memorial Highway
160.1 mi
2h 51m
I 270
19 mi
23m
I 70
13.5 mi
16m
MO 162
9.8 mi
17m
Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi
2m
County Road 281
1.7 mi
6m
US 61
1.6 mi
2m
Rosa Parks Highway
1.5 mi
1m
Longest stretch:
Police Officer Steven Jarvis Memorial Highway
— 160.1 mi, about 2h 51m
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon, MO and Glendale, MO.
1
Start on this road
25 ft·7 sec·this road
2
Turn left onto South Main Street
0.6 mi·1 min·South Main Street
3
Turn left onto Drennen Parkway
0.9 mi·1 min·Drennen Parkway
Use the left lane.
4
Take the ramp
438 ft·6 sec
Toward I 70 East: Saint LouisUse the slight left lane.
5
Merge onto I 70
14 mi·16 min·I 70
Use the straight / slight right lanes.
6
Take the exit
0.2 mi·12 sec
Exit 232Toward I 270: Chicago, MemphisUse the slight right lane.
7
Keep slight right at fork
0.4 mi·33 sec
Toward I 270 South: MemphisUse the slight right lane.
8
Continue on this road
0.1 mi·10 sec·this road
Exit 232Toward I 270 South: Memphis
9
Merge onto I 270
19 mi·23 min·I 270
Use the straight lane.
10
Take the exit
0.4 mi·27 sec
Exit 1AToward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry RoadUse the straight / slight right lanes.
11
Keep slight right at fork
0.4 mi·43 sec
Toward I 55 South: Memphis
12
Merge onto I 55
1.5 mi·1 min·Rosa Parks Highway
13
Continue on I 55
1.8 mi·2 min·Officer Thomas G. Smith, Jr. Memorial Highway
14
Continue on I 55
160 mi·2 hr 51 min·Police Officer Steven Jarvis Memorial Highway
Use the straight / slight right lanes.
15
Take the exit
0.2 mi·25 sec
Exit 32Toward MO 162: Portageville
16
Turn right onto US 61; MO 162
0.6 mi·54 sec·US 61; MO 162
17
Turn right onto US 61; MO 162
1.0 mi·1 min·US 61; MO 162
18
Turn left onto MO 162
9.8 mi·17 min·MO 162
19
Turn left onto County Road 277
1.1 mi·4 min·County Road 277
20
Turn right onto County Road 281
1.7 mi·6 min·County Road 281
21
Turn right onto County Road 282
1.0 mi·3 min·County Road 282
22
Continue on MO VV
0.4 mi·1 min·MO VV
23
Arrive at destination
MO VV
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 107.5 miles from O'Fallon, MO, or about 2h 3m into the drive.
The longest continuous stretch on this route runs about 160.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 47 miles or 58m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 107.5 miles or 2h 3m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 17m
Traffic, exits, and arrival timing usually matter more near Glendale, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving O'Fallon, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from O'Fallon, MO
This is one driving day of about 214.9 miles and 4h 18m.
Your first comfortable stop window is around 47 miles from O'Fallon, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Police Officer Steven Jarvis Memorial Highway for about 160.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 107.5 mi from O'Fallon, MO
· 2h 3m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Ste. Geneviève National Historical Park
National Historical Park
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
5 mi from route
~13 min detour
Free
near mile 81.5
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
14 mi from route
~34 min detour
$19
near mile 37.1
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$33.60 one way
$67.19 round trip
$3.97/gal25.4 MPG avg75 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$36.89
$73.78
premium
$4.89
$41.36
$82.71
diesel
$5.61
$47.45
$94.89
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$34
Meals
$25–$50
Total
$59–$84
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 75.2 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $23 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
64.5
0
$22.56
$10.32
Efficient EV
53.7
0
$18.80
$8.60
EV Truck/SUV
86
1
$30.09
$13.75
Gas CO2
75 kg
EV CO2
25 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
O'Fallon, MO
Night
in O'Fallon on Thursday
Local time
10:11 PM
CDT
Current temp
57°F
Unavailable
Live forecast
Destination
Glendale, MO
Night
in Glendale on Thursday
Local time
10:11 PM
CDT
Current temp
55°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 18m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from O'Fallon, MO to Glendale, MO covers 214.9 miles and takes about 4h 18m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Police Officer Steven Jarvis Memorial Highway, I 270, I 70. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 107.5 miles from O'Fallon, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $33.60 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 17 significant decision points across 214.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 0.6 miles (Drennen Parkway): Lane positioning matters here; at 1.5 miles: Lane positioning matters here; at 15.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
On the drive from O'Fallon, MO to Glendale, MO, road signs begin pointing toward Memphis along the way.
Yes. Nearby national parks include Ste. Geneviève National Historical Park and Gateway Arch National Park.
