The drive from O'Fallon, MO to La Plata, MO covers 163.2 miles and takes about 3h 15m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Avenue of the Saints, Chicago-Kansas City Expressway, North Missouri Street for much of the mileage,
and the overall profile is mixed drive.
The longest uninterrupted segment is about 73.3 miles on Avenue of the Saints.
At current regular gas prices, budget about $25.51 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
81.6 miles from O'Fallon, MO
A natural place for your longest stop of the day
, about 1h 38m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 3h 15m. Total distance: 163.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 15m drive, comfortable solo distance.
Scenic Drive
Mixed drive route profile with national parks nearby.
Drive Character
The drive from O'Fallon, MO to La Plata, MO covers 163.2 miles and takes about 3h 15m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 23 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Avenue of the Saints is the longest continuous segment at about 73.3 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.6 miles in.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 163.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.6 miles: Lane positioning matters here; at 0.6 miles (South Main Street): Sharp turn - reduce speed on approach; at 0.7 miles (West Terra Lane): Lane positioning matters here.
Critical Maneuvers
5 of 20 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
0.6 mi into trip|~1m in
Turn left toward I 70 East
Lane positioning matters here
Use the left lane.
Toward I 70 East
6
0.6 mi into trip|~1m in|South Main Street
Turn sharp left onto South Main Street
Sharp turn - reduce speed on approach
6
0.7 mi into trip|~2m in|West Terra Lane
Turn left onto West Terra Lane
Lane positioning matters here
Use the left lane.
7
7.8 mi into trip|~10m in
Take the exit toward US 61 North: Hannibal
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 210B
Toward US 61 North: Hannibal
6
84.3 mi into trip|~1h 43m in
Take the ramp toward US 36 West, MO 110 West: Monroe City
Multiple destination signs - pick the right one
Toward US 36 West, MO 110 West: Monroe City
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from O'Fallon, MO to La Plata, MO, road signs begin pointing toward Kirksville along the way.
Kirksville
143.2 mi in|~2h 51m
Main Roads
Road
Distance
Duration
Avenue of the Saints
73.3 mi
1h 26m
Chicago-Kansas City Expressway
52.9 mi
1h 1m
North Missouri Street
18.9 mi
21m
I 70
6.9 mi
8m
V.F.W. Memorial Highway
5.8 mi
6m
Veterans Road
2.2 mi
3m
East Clark Street
0.7 mi
1m
South Main Street
0.6 mi
1m
Longest stretch:
Avenue of the Saints
— 73.3 mi, about 1h 26m
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon, MO and La Plata, MO.
1
Start on this road
25 ft·7 sec·this road
2
Turn left onto South Main Street
0.6 mi·1 min·South Main Street
3
Turn left
34 ft·6 sec
Toward I 70 EastUse the left lane.
4
Turn sharp left onto South Main Street
284 ft·11 sec·South Main Street
5
Turn left onto West Terra Lane
0.1 mi·12 sec·West Terra Lane
Use the left lane.
6
Take the ramp
479 ft·6 sec
Toward I 70 West
7
Merge onto I 70
6.9 mi·8 min·I 70
Use the straight / slight right lanes.
8
Take the exit
0.4 mi·47 sec
Exit 210BToward US 61 North: HannibalUse the slight right lane.
9
Merge onto US 61
73 mi·1 hr 26 min·Avenue of the Saints
Use the right lane.
10
Take the exit
249 ft·14 sec
11
Turn left onto Paris Gravel Road
0.5 mi·1 min·Paris Gravel Road
12
Keep slight right at fork onto County Road 422
279 ft·8 sec·County Road 422
13
Turn right onto Veterans Road
2.2 mi·3 min·Veterans Road
14
Take the ramp
0.2 mi·16 sec
Toward US 36 West, MO 110 West: Monroe City
15
Merge onto US 36; MO 110
5.8 mi·6 min·V.F.W. Memorial Highway
16
Continue on US 24; US 36; MO 110
53 mi·1 hr 1 min·Chicago-Kansas City Expressway
17
Take the exit
0.2 mi·28 sec
Toward US 63: Macon, Kirksville
18
Turn right onto US 63
19 mi·21 min·North Missouri Street
19
Take the exit
100 ft·4 sec
20
Turn left onto MO 156
0.7 mi·1 min·East Clark Street
21
Turn right onto South Gex Street
0.2 mi·39 sec·South Gex Street
22
Turn right onto East Moore Street
20 ft·0 sec·East Moore Street
23
Arrive at destination
East Moore Street
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 81.6 miles from O'Fallon, MO, or about 1h 38m into the drive.
The longest continuous stretch on this route runs about 73.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 36 miles or 44m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 81.6 miles or 1h 38m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 40m
Traffic, exits, and arrival timing usually matter more near La Plata, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving O'Fallon, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from O'Fallon, MO
This is one driving day of about 163.2 miles and 3h 15m.
Your first comfortable stop window is around 36 miles from O'Fallon, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Avenue of the Saints for about 73.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 81.6 mi from O'Fallon, MO
· 1h 38m into the drive
Place data sourced from public business listings. Hours and availability may vary.
Fuel & Cost
Regular Gas
$25.51 one way
$51.03 round trip
$3.97/gal25.4 MPG avg57 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$28.01
$56.03
premium
$4.89
$31.41
$62.81
diesel
$5.61
$36.03
$72.07
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$26
Meals
$25–$50
Total
$51–$76
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 57.1 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
13 DC fast chargers
· Coverage: excellent
ChargePoint Charging Station
St Peters, Missouri
ChargePoint
1 DCFC
Blink Charging Station
O'Fallon, Missouri
Blink
1 DCFC
EVXY Charging Station
Troy, Missouri
Other
1 DCFC
EVgo Charging Station
Wentzville, Missouri
EVgo
1 DCFC
Tesla Supercharger
Hannibal, Missouri
Tesla
1 DCFC
Francis Energy Charging Station
Macon, Missouri
Other
1 DCFC
Blink Charging Station
Wentzville, Missouri
Blink
1 DCFC
EVXY Charging Station
Moscow Mills, Missouri
Other
1 DCFC
Other: 5
Blink: 3
ChargePoint: 2
EVgo: 2
Tesla: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $17 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
49
0
$17.14
$7.83
Efficient EV
40.8
0
$14.28
$6.53
EV Truck/SUV
65.3
0
$22.85
$10.44
Gas CO2
57 kg
EV CO2
19 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 17, 2026
Origin
O'Fallon, MO
Afternoon
in O'Fallon on Friday
Local time
3:58 PM
CDT
Current temp
85°F
Mostly Sunny then Chance Showers And Thunderstorms
S 9 to 14 mph36% chanceLive forecast
Destination
La Plata, MO
Afternoon
in La Plata on Friday
Local time
3:58 PM
CDT
Current temp
69°F
Unavailable
Live forecast
71°F
Bowling Green, MO
82 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 15m on the road
The weather snapshot is not static. If you are leaving later, give both cities one more quick forecast check before departure.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from O'Fallon, MO to La Plata, MO covers 163.2 miles and takes about 3h 15m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Avenue of the Saints, Chicago-Kansas City Expressway, North Missouri Street. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 81.6 miles from O'Fallon, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $25.51 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
This is a demanding drive. With 20 significant decision points across 163.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 0.6 miles: Lane positioning matters here; at 0.6 miles (South Main Street): Sharp turn - reduce speed on approach; at 0.7 miles (West Terra Lane): Lane positioning matters here.
On the drive from O'Fallon, MO to La Plata, MO, road signs begin pointing toward Kirksville along the way.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
