The drive from Saint Joseph, MO to Sainte Genevieve, MO covers 354.7 miles and takes about 6h 47m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Police Officer Steven Jarvis Memorial Highway for much of the mileage,
and the overall profile is turn-heavy local drive.
The longest uninterrupted segment is about 135.3 miles on Dwight D. Eisenhower Highway.
At current regular gas prices, budget about $55.45 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
177.3 miles from Saint Joseph, MO
A natural place for your longest stop of the day
, about 3h 14m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 47m. Total distance: 354.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 47m drive, plan rest stops for pacing.
Scenic Drive
Turn-heavy local drive route profile with national parks nearby.
Drive Character
Expect a 6h 47m drive with frequent turns across 354.7 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 43 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D. Eisenhower Highway is the longest continuous segment at about 135.3 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 35.2 miles in near I 435.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 29 significant decision points across 354.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 35.2 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 63.2 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 63.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Critical Maneuvers
5 of 29 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
8
35.2 mi into trip|~39m in|I 435
Keep slight right at fork onto I 435 toward I 435 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Exit 14
Toward I 435 East: Saint Louis
7
63.2 mi into trip|~1h 10m in|US 24
Keep slight right at fork onto US 24 toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 63
Toward I 70, US 24 West, US 40: Saint Louis, Ka...
7
63.5 mi into trip|~1h 11m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Toward I 70 East: Saint Louis
8
291.2 mi into trip|~5h 29m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
8
303.3 mi into trip|~5h 45m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Saint Joseph, MO and Sainte Genevieve, MO, road signs point toward Kansas City, Sports Complex and Memphis.
Kansas City
63.2 mi in|~1h 10m|via US 24
Sports Complex
63.2 mi in|~1h 10m|via US 24
Memphis
291.2 mi in|~5h 29m
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Police Officer Steven Jarvis Memorial Highway
38.1 mi
40m
I 29
28.4 mi
30m
I 435
28 mi
30m
Avenue of the Saints
25.1 mi
30m
I 270
11.5 mi
14m
US 61
7.3 mi
10m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint Joseph, MO and Sainte Genevieve, MO.
1
Start on Walter Welsh Avenue
417 ft·8 sec·Walter Welsh Avenue
2
Turn right onto North 12th Street
297 ft·10 sec·North 12th Street
3
Turn right onto Francis Street
0.2 mi·37 sec·Francis Street
4
Turn left onto I 29 Business
1.2 mi·2 min·North 9th Street
5
Take the ramp
0.1 mi·15 sec
6
Merge onto US 36
0.2 mi·19 sec·US 36
7
Take the exit
0.2 mi·21 sec
Toward I 229 South, US 59 South: Kansas City
8
Merge onto I 229; US 59
4.5 mi·4 min·I 229; US 59
9
Keep slight right at fork
0.3 mi·29 sec
Toward I 29 South, US 71 South: Kansas City
10
Merge onto I 29; US 71
26 mi·27 min·I 29; US 71
11
Merge onto I 29; I 435; US 71
2.2 mi·2 min·I 29; I 435; US 71
Use the straight / slight right lanes.
12
Keep slight right at fork onto I 435
28 mi·30 min·I 435
Exit 14Toward I 435 East: Saint LouisUse the straight / slight right lanes.
13
Keep slight right at fork onto US 24
0.3 mi·23 sec·US 24
Exit 63Toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
14
Keep slight left at fork
1.2 mi·1 min
Toward I 70 East: Saint LouisUse the straight / slight right lanes.
15
Keep slight left at fork
469 ft·11 sec
Toward I 70 East: Saint LouisUse the slight left / straight lanes.
The midpoint is around 177.3 miles from Saint Joseph, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel check
Top up before Dwight D. Eisenhower Highway if your tank is already low. That segment runs about 135.3 miles.
Arriving in Sainte Genevieve, MO
The final approach into Sainte Genevieve, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Sainte Genevieve, MO.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Ste. Geneviève National Historical Park
National Historical Park
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
14 mi from route
~34 min detour
$19
near mile 305.8
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$55.45 one way
$110.91 round trip
$3.97/gal25.4 MPG avg124 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$60.89
$121.77
premium
$4.89
$68.26
$136.52
diesel
$5.61
$78.31
$156.63
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$55
Meals
$25–$50
Total
$80–$105
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 124.1 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
17 DC fast chargers
· Coverage: excellent
Tesla Destination Charger
Kingdom City, Missouri
Tesla Destination
1 DCFC
Rivian Adventure Network
Columbia, Missouri
Rivian
1 DCFC
Tesla Supercharger
Columbia, Missouri
Tesla
1 DCFC
Ionna Charging Station
Warrenton, Missouri
Other
1 DCFC
ChargePoint Charging Station
Kingdom City, Missouri
ChargePoint
1 DCFC
Pilot Flying J Charging Station
Higginsville, Missouri
Other
1 DCFC
EVXY Charging Station
O'Fallon, Missouri
Other
1 DCFC
ChargePoint Charging Station
Columbia, Missouri
ChargePoint
1 DCFC
Other: 8
ChargePoint: 4
Tesla Destination: 1
Rivian: 1
Tesla: 1
Blink: 1
EV Connect: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $37 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
106.4
1
$37.24
$17.03
Efficient EV
88.7
1
$31.04
$14.19
EV Truck/SUV
141.9
1
$49.66
$22.70
Gas CO2
124 kg
EV CO2
41 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Saint Joseph, MO
Afternoon
in Saint Joseph on Thursday
Local time
4:49 PM
CDT
Current temp
74°F
Unavailable
Live forecast
Destination
Sainte Genevieve, MO
Afternoon
in Sainte Genevieve on Thursday
Local time
4:49 PM
CDT
Current temp
56°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
18 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 47m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Saint Joseph, MO to Sainte Genevieve, MO covers 354.7 miles and takes about 6h 47m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Police Officer Steven Jarvis Memorial Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 177.3 miles from Saint Joseph, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $55.45 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 29 significant decision points across 354.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 35.2 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 63.2 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 63.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Between Saint Joseph, MO and Sainte Genevieve, MO, road signs point toward Kansas City, Sports Complex and Memphis.
