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Trip from Saint Peters, MO to Anderson, MO

Drive Time

5h 50m

Distance

307.8 mi

495 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$47

one way

Downtown Saint Peters, MO, MO

Saint Peters, MO

Aleksandra Żmuda

Downtown Anderson, MO, MO

Anderson, MO

life vibes

Trip Overview

The drive from Saint Peters, MO to Anderson, MO covers 307.8 miles and takes about 5h 50m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on I 44, I 49, MO 100 for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 240.9 miles on I 44. At current regular gas prices, budget about $46.75 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

153.9 miles from Saint Peters, MO

A natural place for your longest stop of the day , about 3h 2m into the drive .

Drive Character

This is a 5h 50m highway drive covering 307.8 miles, with most of the trip on I 44 and I 49. The longest continuous stretch is about 240.9 miles on I 44.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 29 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 44 is the longest continuous segment at about 240.9 miles.

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on I 44 and I 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 3 miles in.

Route Complexity 7/10

Demanding - plan breaks and stay ahead of the key maneuvers

This is a demanding drive. With 21 significant decision points across 307.8 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 10.5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 14.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.

Critical Maneuvers

5 of 21 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

8
3 mi into trip | ~3m in

Take the exit toward MO K: O'Fallon, Main Street

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 218 Toward MO K: O'Fallon, Main Street
6
10.5 mi into trip | ~16m in

Take the ramp toward I 64 East, US 40 East, US 61 South

Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Toward I 64 East, US 40 East, US 61 South
7
14.5 mi into trip | ~21m in

Take the exit toward Chesterfield Airport Road

Exit ramp - move to the correct lane early. Lane positioning matters here

Use the slight right lane. Exit 14 Toward Chesterfield Airport Road
6
277.9 mi into trip | ~5h 16m in | I 49; US 71

Take the exit onto I 49; US 71 toward I 49 South, US 71 South, MO 249 North: Neosho, Fort Smith

Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one

Exit 11 Toward I 49 South, US 71 South, MO 249 North: N...
6
278.1 mi into trip | ~5h 17m in | I 49; US 71

Keep slight left at fork onto I 49; US 71 toward I 49 South, US 71 South: Neosho, Fort Smith

Highway fork - watch signs carefully. Multiple destination signs - pick the right one

Toward I 49 South, US 71 South: Neosho, Fort Sm...

Towns Along This Route

On the drive from Saint Peters, MO to Anderson, MO, road signs begin pointing toward Fort Smith along the way.

Fort Smith

277.9 mi in | ~5h 16m | via I 49; US 71

Main Roads

Road Distance Duration
I 44 240.9 mi 4h 19m
I 49 24.3 mi 26m
MO 100 13.3 mi 18m
MO K 6.5 mi 11m
US 71 Business 4.9 mi 6m
MO 109 4.7 mi 7m
Avenue of the Saints 3.7 mi 4m
I 70 3 mi 3m
Longest stretch: I 44 — 240.9 mi, about 4h 19m

Turn-by-Turn Driving Directions

Step-by-step road directions between Saint Peters, MO and Anderson, MO.

1

Start on I 70

3.0 mi · 3 min · I 70
Use the straight / slight right lanes.
2

Take the exit

390 ft · 8 sec
Exit 218 Toward MO K: O'Fallon, Main Street Use the slight right lane.
3

Turn straight onto East Terra Lane

0.9 mi · 1 min · East Terra Lane
Use the straight lane.
4

Turn slight left

61 ft · 1 sec
5

Continue on MO K

3.1 mi · 5 min · MO K
Use the left lane.
6

Continue on MO K

3.4 mi · 5 min · MO K
Use the straight lane.
7

Take the ramp

0.3 mi · 21 sec
Toward I 64 East, US 40 East, US 61 South Use the slight right lane.
8

Merge onto I 64; US 40; US 61

3.7 mi · 4 min · Avenue of the Saints
9

Take the exit

0.5 mi · 57 sec
Exit 14 Toward Chesterfield Airport Road Use the slight right lane.
10

Continue on Chesterfield Airport Road

361 ft · 6 sec · Chesterfield Airport Road
11

Turn right

211 ft · 5 sec
Toward Olive Street Road
12

Turn right onto Olive Street Road

0.9 mi · 1 min · Olive Street Road
13

Continue on North Eatherton Road

2.4 mi · 4 min · North Eatherton Road
14

Enter roundabout onto MO 109

70 ft · 1 sec · MO 109
15

Continue on MO 109

4.3 mi · 6 min · MO 109
16

Enter roundabout onto MO 109

94 ft · 2 sec · MO 109
17

Continue on MO 109

0.4 mi · 44 sec · MO 109
18

Enter roundabout

76 ft · 1 sec
Toward MO 100 West: Gray Summit
19

Continue

0.2 mi · 32 sec
Toward MO 100 West: Gray Summit
20

Merge onto MO 100

13 mi · 18 min · MO 100
21

Take the exit

0.2 mi · 14 sec
Toward I 44 West, US 50 West: St. Clair
22

Merge onto I 44; US 50

241 mi · 4 hr 19 min · I 44; US 50
Use the straight lane.
23

Take the exit onto I 49; US 71

0.3 mi · 24 sec · I 49; US 71
Exit 11 Toward I 49 South, US 71 South, MO 249 North: Neosho, Fort Smith
24

Keep slight left at fork onto I 49; US 71

24 mi · 26 min · I 49; US 71
Toward I 49 South, US 71 South: Neosho, Fort Smith
25

Take the exit onto US 71 Business

0.3 mi · 31 sec · US 71 Business
Exit 16 Toward MO 59, US 71 Business: Goodman, Anderson
26

Continue on US 71 Business; MO 59

4.7 mi · 5 min · US 71 Business; MO 59
27

Turn right onto MO 59; MO 76

0.5 mi · 53 sec · North State Highway 59
28

Turn left onto Jefferson Street

0.1 mi · 24 sec · Jefferson Street
29

Arrive at destination

East Street

Trip Plan

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 153.9 miles from Saint Peters, MO, or about 3h 2m into the drive.
The longest continuous stretch on this route runs about 240.9 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 43m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 153.9 miles or 3h 2m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 4h 49m

Traffic, exits, and arrival timing usually matter more near Anderson, MO than in the middle of the route.

Before You Leave

+

Open the route before leaving Saint Peters, MO so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Saint Peters, MO

This is one driving day of about 307.8 miles and 5h 50m.

Your first comfortable stop window is around 80 miles from Saint Peters, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 44 for about 240.9 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 153.9 mi from Saint Peters, MO · 3h 2m into the drive

Downtown Cahokia, IL, IL

Mid-route town

Meal stop

Cahokia, IL

154 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Cahokia, IL

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Cahokia, IL

Meal break

The midpoint is around 153.9 miles from Saint Peters, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before I 44 if your tank is already low. That segment runs about 240.9 miles.

Arriving in Anderson, MO

The final approach into Anderson, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Anderson, MO.

After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$46.75 one way

$93.50 round trip

$3.86/gal 25.4 MPG avg 108 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.25 $51.54 $103.08
premium $4.80 $58.11 $116.21
diesel $5.64 $68.38 $136.76

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$47

Meals

$25–$50

Total

$72–$97

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 107.7 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $32 in charging · 1 stop · 67% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 92.3 1 $32.32 $14.77
Efficient EV 77 0 $26.93 $12.31
EV Truck/SUV 123.1 1 $43.09 $19.70

Gas CO2

108 kg

EV CO2

36 kg (67% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 2 days ago

Origin

Saint Peters, MO

Afternoon in Saint Peters on Sunday

Local time

2:33 PM

CDT

Current temp

54°F

Unavailable

Live forecast

Destination

Anderson, MO

Afternoon in Anderson on Sunday

Local time

2:33 PM

CDT

Current temp

82°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

28 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

5h 50m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Saint Peters, MO to Anderson, MO covers 307.8 miles and takes about 5h 50m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 44, I 49, MO 100. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 153.9 miles from Saint Peters, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $46.75 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 21 significant decision points across 307.8 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 10.5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 14.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
On the drive from Saint Peters, MO to Anderson, MO, road signs begin pointing toward Fort Smith along the way.

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