Origin
Sainte Genevieve County, MO
Afternoon in Sainte Genevieve County on Friday
Local time
1:09 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Trip from Sainte Genevieve County, MO to Cape Girardeau, MO
Compiled and reviewed by the Trip.ovh planning team at COD Solutions Oy · Last reviewed Apr 17, 2026 · Editorial standards
Drive Time
1h 20m
Distance
64.6 mi
104 km
Drive Score
7/10
Good drive
Same Day?
Yes, doable
Fuel Cost
$10
one way
EV Charging
Unknown
Best Time to Leave
4 AM
1h 14m
★
6 AM
1h 21m
8 AM
1h 33m
10 AM
1h 25m
12 PM
1h 24m
3 PM
1h 26m
5 PM
1h 33m
8 PM
1h 17m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Sainte Genevieve County, MO
Thomas Parker
Cape Girardeau, MO
Wikimedia Commons
Trip Overview
The drive from Sainte Genevieve County, MO to Cape Girardeau, MO covers 64.6 miles and takes about 1h 20m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 55, MO 32, North Kingshighway for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 50.1 miles on I 55. At current regular gas prices, budget about $10.10 one way before food or hotel costs.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 1h 20m. Total distance: 64.6 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
1h 20m drive, comfortable solo distance.
EV Driver
0 DC fast chargers along the route. Coverage: unknown.
First-Time Driver
Mostly highway driving (88%). Straightforward navigation.
Drive Character
This is a 1h 20m highway drive covering 64.6 miles, with most of the trip on I 55 and MO 32. The longest continuous stretch is about 50.1 miles on I 55.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 10 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 55 is the longest continuous segment at about 50.1 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 55 and MO 32. Navigation is very simple - set it and forget it for most of the drive. The trickiest moment comes around 0.6 miles in near River Aux Vases Church Road.
Driving Effort
2/10
Very easy - short and simple to drive
Balances navigation complexity with total wheel time.
The drive from Sainte Genevieve County, MO to Cape Girardeau, MO is easy. At 1h 20m with 88% highway, most drivers will find it relaxed and low-stress.
Where does it get tricky?
The main spots that need attention: at 0.6 miles (River Aux Vases Church Road): Navigation decision point; at 1.5 miles (MO 32): Navigation decision point; at 8.2 miles: Navigation decision point.
Critical Maneuvers
5 of 7 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
3
0.6 mi into trip
|
~2m in
|
River Aux Vases Church Road
Turn right onto River Aux Vases Church Road
Navigation decision point
3
1.5 mi into trip
|
~5m in
|
MO 32
Turn right onto MO 32
Navigation decision point
4
8.2 mi into trip
|
~15m in
Take the ramp toward I 55 South: Perryville
Navigation decision point
Toward I 55 South: Perryville
6
58.5 mi into trip
|
~1h 9m in
Take the exit toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 99
Toward US 61, MO 34, I 55 Business: Cape Girard...
8
58.7 mi into trip
|
~1h 10m in
Keep slight left at fork toward I 55 Business, US 61 South, MO 34 East: Cape Girardeau
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 99
Toward I 55 Business, US 61 South, MO 34 East:...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Sainte Genevieve County, MO to Cape Girardeau, MO, road signs begin pointing toward Jackson along the way.
Jackson
58.5 mi in
|
~1h 9m
Main Roads
| Road | Distance | Duration |
|---|---|---|
| I 55 | 50.1 mi | 53m |
| MO 32 | 6.7 mi | 10m |
| North Kingshighway | 3.6 mi | 6m |
| Broadway Street | 2 mi | 3m |
| River Aux Vases Church Road | 0.9 mi | 3m |
Longest stretch:
I 55
— 50.1 mi, about 53m
Turn-by-Turn Driving Directions
Step-by-step road directions between Sainte Genevieve County, MO and Cape Girardeau, MO.
1
Start on this road
0.6 mi
·
2 min
·
this road
2
Turn right onto River Aux Vases Church Road
0.9 mi
·
3 min
·
River Aux Vases Church Road
3
Turn right onto MO 32
6.7 mi
·
10 min
·
MO 32
4
Take the ramp
0.2 mi
·
29 sec
Toward I 55 South: Perryville
5
Merge onto I 55
50 mi
·
53 min
·
I 55
6
Take the exit
0.2 mi
·
17 sec
Exit 99
Toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
7
Keep slight left at fork
0.3 mi
·
28 sec
Exit 99
Toward I 55 Business, US 61 South, MO 34 East: Cape Girardeau
8
Continue on I 55 Bus; US 61; MO 34
3.6 mi
·
6 min
·
North Kingshighway
9
Turn left onto Broadway Street
2.0 mi
·
3 min
·
Broadway Street
10
Arrive at destination
Broadway Street
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 32.3 mi from Sainte Genevieve County, MO · 41m into the drive
Mid-route town
Meal stop
32 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 14 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 32.3 miles from Sainte Genevieve County, MO, which is a good place for a longer meal and fuel stop.
Arriving in Cape Girardeau, MO
The final approach into Cape Girardeau, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$10.10 one way
$20.20 round trip
$3.97/gal
25.4 MPG avg
23 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $11.09 | $22.18 |
| premium | $4.89 | $12.43 | $24.86 |
| diesel | $5.61 | $14.26 | $28.53 |
No toll roads detected on this route.
Drive Cost (one way)
Fuel
$10
Estimated CO2 emission: 22.6 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $7 in charging · 0 stops · 65% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 19.4 | 0 | $6.78 | $3.10 |
| Efficient EV | 16.2 | 0 | $5.65 | $2.58 |
| EV Truck/SUV | 25.8 | 0 | $9.04 | $4.13 |
Gas CO2
23 kg
EV CO2
8 kg (65% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Cape Girardeau, MO
Afternoon in Cape Girardeau on Friday
Local time
1:09 PM
CDT
Current temp
81°F
Unavailable
Live forecast
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
20 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
1h 20m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Sainte Genevieve County, MO to Cape Girardeau, MO covers 64.6 miles and takes about 1h 20m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 55, MO 32, North Kingshighway. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 32.3 miles from Sainte Genevieve County, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $10.10 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Leave by 9 AM and you'll arrive before lunch. Even a 4 PM departure gets you there before dark in summer.
The drive from Sainte Genevieve County, MO to Cape Girardeau, MO is easy. At 1h 20m with 88% highway, most drivers will find it relaxed and low-stress.
The main spots that need attention: at 0.6 miles (River Aux Vases Church Road): Navigation decision point; at 1.5 miles (MO 32): Navigation decision point; at 8.2 miles: Navigation decision point.
On the drive from Sainte Genevieve County, MO to Cape Girardeau, MO, road signs begin pointing toward Jackson along the way.
Yes. Nearby national parks include Ste. Geneviève National Historical Park.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
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