Trip from San Antonio, TX to Odessa, TX

Drive Time

5h 55m

Distance

340.2 mi

Route Type

Turn-heavy local drive

Long day trip

Trip Overview

The drive from San Antonio, TX to Odessa, TX covers 340.2 miles and takes about 5h 55m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on West Market Street, Navarro Street, San Pedro Avenue for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $50.61 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

170.1 miles from San Antonio, TX

A natural place for your longest stop of the day.

Drive Character

Expect a 5h 55m drive with frequent turns across 340.2 miles of local and secondary roads.

This route has more turning and local-road decision points than a simple highway run.

There are about 18 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

West Market Street is one of the defining roads on this drive.

Main Roads

Road	Distance	Duration
West Market Street	0 mi	0m
Navarro Street	0 mi	0m
San Pedro Avenue	0 mi	0m
West Cypress Street	0 mi	0m
East Fredericksburg Road	0 mi	0m
Interstate 10 West	0 mi	0m
I 10 West	0 mi	0m
McDermott Freeway	0 mi	0m

Longest stretch: West Market Street — 0 mi, about 0m

Step-by-Step Directions

1

Start on Dolorosa Street

2

Continue on West Market Street

3

Turn left onto Navarro Street

4

Enter the roundabout and take exit 2 toward San Pedro Avenue

5

Exit the roundabout onto San Pedro Avenue

6

Turn left onto West Cypress Street

7

Turn straight onto East Fredericksburg Road

8

Turn right onto Interstate 10 West

9

Take the ramp slight left toward I 10 West, US 87 North

10

Merge slight left onto McDermott Freeway

11

Keep slight right

12

Take the exit slight right toward US 190, FM 305: Iraan, McCamey

13

Continue on I 10 Service Road

14

Turn right

15

Turn left onto Farm to Market Road 305

16

Continue on South Burleson Avenue

17

Continue straight

18

Arrive at your destination

When to Leave

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 170.1 miles from San Antonio, TX.

This is a comfortable same-day trip.

Drive Plan

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 170.1 miles

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Last hour of driving

Traffic, exits, and arrival timing usually matter more near Odessa, TX than in the middle of the route.

Before You Leave

+

Open the route before leaving San Antonio, TX so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Trip Strategy

Day 1

Settle into the route from San Antonio, TX

This is one driving day of about 340.2 miles and 5h 55m.

Your first comfortable stop window is around 80 miles from San Antonio, TX.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

Best Stop Towns on This Route

These towns line up with the pace of this drive and give you clearer places to stop with a purpose.

Late stop town

Meal stop

Alamo Heights, TX

170 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Travel Advice

Arrival Notes

The final approach into Odessa, TX usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Odessa, TX.

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Stops Along the Way

Halfway Point

Midpoint

About 170.1 mi from San Antonio, TX

Alamo Heights, TX

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Alamo Heights, TX

Meal break

The midpoint is around 170.1 miles from San Antonio, TX, which is a good place for a longer meal and fuel stop.

These stop ideas are pacing suggestions for the drive, so the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Fuel Type	$/gal	One Way	Round Trip
regular	$3.78	$50.61	$101.23
midgrade	$4.25	$56.95	$113.90
premium	$4.59	$61.49	$122.98
diesel	$3.99	$53.48	$106.96

Based on 25.4 MPG average. Estimated CO2 emission: 119 kg one way.

Frequently Asked Questions

The drive from San Antonio, TX to Odessa, TX covers 340.2 miles and takes about 5h 55m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are West Market Street, Navarro Street, San Pedro Avenue. Expect a mix of highway and local road driving.

This is a comfortable same-day trip.

The midpoint is about 170.1 miles from San Antonio, TX. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $50.61 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.

Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.