The drive from Smyrna, TN to Knoxville, TN covers 294.4 miles and takes about 5h 38m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 40, US 641, Broadway of America for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 258.1 miles on I 40.
At current regular gas prices, budget about $44.72 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
147.2 miles from Smyrna, TN
A natural place for your longest stop of the day
, about 2h 56m into the drive
.