Trip from Tupelo, MS to Taylorsville, MS

Last recalculated Apr 16, 2026

Drive Time

4h 22m

Distance

220.6 mi

355 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$33

one way

EV Charging

Unknown

Best Time to Leave

Save up to 40 min

4 AM

4h 9m ★

6 AM

4h 22m

8 AM

4h 49m

10 AM

4h 32m

12 PM

4h 29m

3 PM

4h 33m

5 PM

4h 48m

8 PM

4h 14m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly

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Tupelo, MS

Wikimedia Commons

Taylorsville, MS

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Trip Overview

This 220.6-mile drive from Tupelo, Mississippi, to Taylorsville, Mississippi, will take you approximately 4 hours and 22 minutes to complete. It's a straightforward journey primarily on US Highway 45 Alternate and I-59, with 92% of the route being highway driving. Considering the duration and distance, this trip is easily manageable as a single-day excursion, with an estimated fuel cost of around $33. You'll be traveling within the Southeast region for the entire trip, experiencing a consistent feel as you head south. This route offers a practical way to cover ground efficiently.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

110.3 miles from Tupelo, MS

A natural place for your longest stop of the day , about 2h 11m into the drive .

Who Is This Route For?

Weekend Trip

Doable as a same-day drive at 4h 22m. Total distance: 220.6 miles.

Family Friendly

Moderate complexity with 1 natural rest stops along the way.

Solo Traveler

4h 22m drive, comfortable solo distance.

First-Time Driver

Mostly highway driving (92%). Some complex stretches to watch for.

Drive Character

Expect a highway-focused drive for the majority of this trip, with 92% of the 220.6 miles spent on main roads like US Highway 45 Alternate and I-59. The longest uninterrupted stretch you'll encounter is 60.6 miles on US Highway 45 Alternate, offering a solid period of consistent travel. While largely a highway experience, the shift between these major arteries will provide some variation. This route is designed for making miles, so you'll experience a steady pace for most of the 4-hour journey.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.

There are about 34 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

US Highway 45 Aiternate is the longest continuous segment at about 60.6 miles.

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on US Highway 45 Aiternate and US Highway 45 Alternate. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near Court Street.

Driving Effort 8/10

Demanding - plan breaks and stay ahead of the key maneuvers

Balances navigation complexity with total wheel time.

This is a demanding drive. With 15 significant decision points across 220.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: near the start (Court Street): Navigation decision point; at 0.1 miles (East Main Street): Lane positioning matters here; at 147 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.

Critical Maneuvers

5 of 15 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

0 mi into trip | ~0m in | Court Street

Turn right onto Court Street

Navigation decision point

0.1 mi into trip | ~0m in | East Main Street

Turn left onto East Main Street

Lane positioning matters here

Use the left lane.

147 mi into trip | ~2h 54m in | I 59

Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left / slight right lanes. Toward I 59 South: Laurel, New Orleans

198.2 mi into trip | ~3h 49m in

Take the exit toward US 84 East: Waynesboro, Chantilly Street

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Toward US 84 East: Waynesboro, Chantilly Street

199.4 mi into trip | ~3h 51m in | Sawmill Road

Enter roundabout onto Sawmill Road

Roundabout - know your exit number before entering

Towns Mentioned on Route Signs

Based on OSRM destination-sign hints, not a full list of every settlement the road passes.

On the drive from Tupelo, MS to Taylorsville, MS, road signs begin pointing toward New Orleans along the way.

New Orleans

147 mi in | ~2h 54m | via I 59

Main Roads

Road	Distance	Duration
US Highway 45 Aiternate	60.6 mi	1h 9m
US Highway 45 Alternate	54.7 mi	1h 6m
I 59	51.2 mi	54m
MS 28	16.7 mi	24m
Martin Luther King Drive	8.7 mi	10m
I 20	8.1 mi	9m
US 45 ALT	7.2 mi	8m
US 45	3.9 mi	4m

Longest stretch: US Highway 45 Aiternate — 60.6 mi, about 1h 9m

Turn-by-Turn Driving Directions

Step-by-step road directions between Tupelo, MS and Taylorsville, MS.

Start on North Spring Street

68 ft · 5 sec · North Spring Street

Turn right onto Court Street

317 ft · 16 sec · Court Street

Turn right onto North Front Street

287 ft · 15 sec · North Front Street

Turn left onto East Main Street

0.5 mi · 1 min · East Main Street

Use the left lane.

Take the ramp

0.4 mi · 55 sec

Merge onto US 45; MS 6

1.0 mi · 1 min · Martin Luther King Drive

Continue on US 45; MS 6

2.3 mi · 2 min · Martin Luther King, Junior Drive

Continue on US 45; US 278

7.7 mi · 8 min · Martin Luther King Drive

Continue on US 45 ALT

1.4 mi · 1 min · US 45 ALT

Continue on US 45 ALT

2.2 mi · 2 min · US 45 ALT

Continue on US 45 ALT

1.5 mi · 1 min · US 45 ALT

Continue on US 45 ALT

0.7 mi · 49 sec · US 45 ALT

Continue on US 45 ALT

1.4 mi · 1 min · US 45 ALT

Continue on US 45 ALT

55 mi · 1 hr 6 min · US Highway 45 Alternate

Use the straight lane.

Continue on US 45

61 mi · 1 hr 9 min · US Highway 45 Aiternate

Keep slight right at fork onto US 45

3.9 mi · 4 min · US 45

Take the exit

0.5 mi · 1 min

Toward I 59 South, I 20 West: Meridian

Merge onto I 20; I 59

6.3 mi · 7 min · I 20; I 59

Use the straight / slight right lanes.

Continue on I 20; I 59; US 80

1.8 mi · 2 min · I 20; I 59; US 80

Use the straight lane.

Keep slight left at fork onto I 59

51 mi · 54 min · I 59

Toward I 59 South: Laurel, New Orleans Use the slight left / slight right lanes.

Take the exit

0.2 mi · 19 sec

Toward US 84 East: Waynesboro, Chantilly Street Use the slight right lane.

Keep slight right at fork

221 ft · 6 sec

Turn straight onto Chantilly Street

0.2 mi · 22 sec · Chantilly Street

At end of road, turn left onto US 11

0.2 mi · 17 sec · Cross Street

Continue on US 11

0.2 mi · 26 sec · Teresa Street

Turn left onto North Magnolia Street

0.1 mi · 11 sec · North Magnolia Street

Continue on Sawmill Road

0.2 mi · 22 sec · Sawmill Road

Keep slight left at fork onto Sawmill Road

473 ft · 10 sec · Sawmill Road

Enter roundabout onto Sawmill Road

72 ft · 1 sec · Sawmill Road

Continue on Sawmill Road

0.5 mi · 59 sec · Sawmill Road

Continue on West 5th Street

0.3 mi · 41 sec · West 5th Street

Continue on US 84; MS 28

3.7 mi · 4 min · Veterans Memorial Highway

Turn right onto MS 28

17 mi · 24 min · MS 28

Arrive at destination

MS 28

Trip Plan

For this 4-hour and 22-minute drive, leaving Tupelo in the morning will give you ample time to reach Taylorsville without feeling rushed. With only one stop suggested for this 220.6-mile journey, you have flexibility in planning your breaks. Keep an eye on your fuel gauge, especially during the longest stretch of 60.6 miles on US Highway 45 Alternate, as services can sometimes be spaced out on these highways. The estimated $33 fuel cost is a helpful budget point for planning this single-day trip.

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 110.3 miles from Tupelo, MS, or about 2h 11m into the drive.

The longest continuous stretch on this route runs about 60.6 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 49 miles or 59m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 110.3 miles or 2h 11m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 3h 30m

Traffic, exits, and arrival timing usually matter more near Taylorsville, MS than in the middle of the route.

Before You Leave

Open the route before leaving Tupelo, MS so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Tupelo, MS

This is one driving day of about 220.6 miles and 4h 22m.

Your first comfortable stop window is around 49 miles from Tupelo, MS.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

The longest stretch is on US Highway 45 Aiternate for about 60.6 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 110.3 mi from Tupelo, MS · 2h 11m into the drive

Mid-route town

Meal stop

Meridian, MS

110 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Starkville, MS

Fuel and coffee

A short stop after about 49 miles helps settle the day before fatigue starts building.

Macon, MS

Meal break

The midpoint is around 110.3 miles from Tupelo, MS, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before US Highway 45 Aiternate if your tank is already low. That segment runs about 60.6 miles.

Arriving in Taylorsville, MS

The final approach into Taylorsville, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Taylorsville, MS.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$33.32 one way

$66.63 round trip

$3.84/gal 25.4 MPG avg 77 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.21	$36.57	$73.15
premium	$4.56	$39.60	$79.19
diesel	$5.61	$48.71	$97.41

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$33

Meals

$25–$50

Total

$58–$83

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 77.2 kg one way. Prices: EIA weekly data, 2026-04-13.

Driving Electric?

About $23 in charging · 0 stops · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	66.2	0	$23.16	$10.59
Efficient EV	55.2	0	$19.30	$8.82
EV Truck/SUV	88.2	1	$30.88	$14.12

Gas CO2

77 kg

EV CO2

26 kg (66% less)

Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast as of Apr 15, 2026

Origin

Tupelo, MS

Evening in Tupelo on Thursday

Local time

5:31 PM

CDT

Current temp

78°F

Unavailable

Live forecast

Destination

Taylorsville, MS

Evening in Taylorsville on Thursday

Local time

5:31 PM

CDT

Current temp

62°F

Unavailable

Live forecast

79°F

Meridian, MS

110 mi in

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

16 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

4h 22m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Tupelo, MS to Taylorsville, MS covers 220.6 miles and takes about 4h 22m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are US Highway 45 Aiternate, US Highway 45 Alternate, I 59. Most of the drive stays on highways, so watch for ramps and exits.

This is a comfortable same-day trip.

The midpoint is about 110.3 miles from Tupelo, MS. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $33.32 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.

Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

On the drive from Tupelo, MS to Taylorsville, MS, road signs begin pointing toward New Orleans along the way.

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