The drive from Weatherby Lake, MO to O'Fallon, MO covers 235 miles and takes about 4h 30m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, I 435 for much of the mileage,
and the overall profile is turn-heavy local drive.
The longest uninterrupted segment is about 142.5 miles on Dwight D. Eisenhower Highway.
At current regular gas prices, budget about $36.74 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
117.5 miles from Weatherby Lake, MO
A natural place for your longest stop of the day
, about 2h 12m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 30m. Total distance: 235 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 30m drive, comfortable solo distance.
Scenic Drive
Turn-heavy local drive route profile with national parks nearby.
Drive Character
Expect a 4h 30m drive with frequent turns across 235 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 28 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D. Eisenhower Highway is the longest continuous segment at about 142.5 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 24.1 miles in near US 24.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 15 significant decision points across 235 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 24.1 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 24.4 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 25.6 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Critical Maneuvers
5 of 15 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
7
24.1 mi into trip|~30m in|US 24
Keep slight right at fork onto US 24 toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 63
Toward I 70, US 24 West, US 40: Saint Louis, Ka...
7
24.4 mi into trip|~31m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Toward I 70 East: Saint Louis
7
25.6 mi into trip|~32m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left / straight lanes.
Toward I 70 East: Saint Louis
6
234 mi into trip|~4h 27m in
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Toward MO K: O'Fallon
6
234.4 mi into trip|~4h 28m in|Drennen Parkway
Keep slight right at fork onto Drennen Parkway toward MO K: O'Fallon
Highway fork - watch signs carefully
Toward MO K: O'Fallon
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Weatherby Lake, MO and O'Fallon, MO, road signs point toward Kansas City and Sports Complex.
Kansas City
24.1 mi in|~30m|via US 24
Sports Complex
24.1 mi in|~30m|via US 24
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
142.5 mi
2h 42m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
I 435
12.3 mi
13m
Alexander Doniphan Memorial Highway
9.6 mi
11m
Truman/Eisenhower Presidential Highway
5.6 mi
6m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Clifton J. Scott Memorial Highway
1.8 mi
2m
Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
1m
Longest stretch:
Dwight D. Eisenhower Highway
— 142.5 mi, about 2h 42m
Turn-by-Turn Driving Directions
Step-by-step road directions between Weatherby Lake, MO and O'Fallon, MO.
1
Start on Northwest Potomac Avenue
0.7 mi·2 min·Northwest Potomac Avenue
2
At end of road, turn right onto Northwest Barry Road
0.4 mi·47 sec·Northwest Barry Road
3
Turn left onto North Amity Avenue
0.4 mi·55 sec·North Amity Avenue
4
Take the ramp
0.3 mi·35 sec
Toward MO 152 East: Liberty
5
Merge onto MO 152
9.6 mi·11 min·Alexander Doniphan Memorial Highway
6
Take the exit
0.5 mi·51 sec
Toward I 435 South: Saint Louis
7
Merge onto I 435
12 mi·13 min·I 435
Use the slight right lane.
8
Keep slight right at fork onto US 24
0.3 mi·23 sec·US 24
Exit 63Toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
9
Keep slight left at fork
1.2 mi·1 min
Toward I 70 East: Saint LouisUse the straight / slight right lanes.
10
Keep slight left at fork
469 ft·11 sec
Toward I 70 East: Saint LouisUse the slight left / straight lanes.
Place data sourced from public business listings. Hours and availability may vary.
Fuel & Cost
Regular Gas
$36.74 one way
$73.48 round trip
$3.97/gal25.4 MPG avg82 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$40.34
$80.68
premium
$4.89
$45.22
$90.45
diesel
$5.61
$51.89
$103.77
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$37
Meals
$25–$50
Total
$62–$87
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 82.2 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
15 DC fast chargers
· Coverage: excellent
ChargePoint Charging Station
St Peters, Missouri
ChargePoint
1 DCFC
Blink Charging Station
O'Fallon, Missouri
Blink
1 DCFC
Tesla Destination Charger
Kingdom City, Missouri
Tesla Destination
1 DCFC
Flying J EV Charging Station
Warrenton, Missouri
Other
1 DCFC
Tesla Supercharger
Columbia, Missouri
Tesla
1 DCFC
Pilot EV Charging Station
Boonville, Missouri
Other
1 DCFC
Electrify America Charging Station
Boonville, Missouri
Electrify America
1 DCFC
ChargePoint Charging Station
Kingdom City, Missouri
ChargePoint
1 DCFC
Other: 4
ChargePoint: 3
Blink: 2
Tesla Destination: 2
Tesla: 1
Electrify America: 1
EVgo: 1
EV Connect: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $25 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
70.5
0
$24.67
$11.28
Efficient EV
58.8
0
$20.56
$9.40
EV Truck/SUV
94
1
$32.90
$15.04
Gas CO2
82 kg
EV CO2
27 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Weatherby Lake, MO
Afternoon
in Weatherby Lake on Friday
Local time
2:45 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
O'Fallon, MO
Afternoon
in O'Fallon on Friday
Local time
2:45 PM
CDT
Current temp
57°F
Unavailable
Live forecast
55°F
New Franklin, MO
118 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
20 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 30m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Weatherby Lake, MO to O'Fallon, MO covers 235 miles and takes about 4h 30m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, I 435. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 117.5 miles from Weatherby Lake, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $36.74 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 15 significant decision points across 235 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 24.1 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 24.4 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 25.6 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Between Weatherby Lake, MO and O'Fallon, MO, road signs point toward Kansas City and Sports Complex.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
