The drive from Webb City, MO to Cape Girardeau, MO covers 337.6 miles and takes about 6h 33m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 60, Congressman Gene Taylor Highway, I 55 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 227.5 miles on US 60.
At current regular gas prices, budget about $52.78 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
168.8 miles from Webb City, MO
A natural place for your longest stop of the day
, about 3h 14m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 33m. Total distance: 337.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 33m drive, plan rest stops for pacing.
Drive Character
This is a 6h 33m highway drive covering 337.6 miles, with most of the trip on US 60 and Congressman Gene Taylor Highway. The longest continuous stretch is about 227.5 miles on US 60.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 28 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 60 is the longest continuous segment at about 227.5 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 60 and Congressman Gene Taylor Highway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.7 miles in near I 49 Business; MO 171.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 337.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.7 miles (I 49 Business; MO 171): Roundabout - know your exit number before entering; at 5.3 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 158.3 miles (US 60): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 19 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
0.7 mi into trip|~1m in|I 49 Business; MO 171
Enter roundabout onto I 49 Business; MO 171
Roundabout - know your exit number before entering
5
5.3 mi into trip|~6m in
Take the exit toward MO 66, I 44 Business
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward MO 66, I 44 Business
6
158.3 mi into trip|~3h 2m in|US 60
Keep slight left at fork onto US 60 toward US 60 East: Mountain View, Poplar Bluff
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 60 East: Mountain View, Poplar Bluff
7
332.8 mi into trip|~6h 24m in|US 61
Keep slight right at fork onto US 61 toward US 61, I 55 Business: Cape Girardeau
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 93B
Toward US 61, I 55 Business: Cape Girardeau
6
336.4 mi into trip|~6h 30m in|MO 177 / South Sprigg Street
Turn left onto MO 177 / South Sprigg Street
Lane positioning matters here
Use the left lane.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Webb City, MO to Cape Girardeau, MO, road signs begin pointing toward Poplar Bluff along the way.
Poplar Bluff
158.3 mi in|~3h 2m|via US 60
Main Roads
Road
Distance
Duration
US 60
227.5 mi
4h 26m
Congressman Gene Taylor Highway
53.2 mi
57m
I 55
27.4 mi
29m
James River Freeway
14.4 mi
16m
Governor Warren E Hearnes Memorial Highway
3.4 mi
3m
US 61
2 mi
2m
East 7th Street
2 mi
3m
Shawnee Parkway
1.6 mi
2m
Longest stretch:
US 60
— 227.5 mi, about 4h 26m
Turn-by-Turn Driving Directions
Step-by-step road directions between Webb City, MO and Cape Girardeau, MO.
1
Start on MO D
0.4 mi·38 sec·North Main Street
2
Turn left onto I 49 Business; MO 171
0.3 mi·39 sec·East MacArthur Drive
3
Enter roundabout onto I 49 Business; MO 171
234 ft·3 sec·I 49 Business; MO 171
4
Continue on I 49 Business; MO 171
0.6 mi·37 sec·I 49 Business; MO 171
5
Take the exit
0.6 mi·41 sec
Toward MO 249 South: Joplin
6
Merge onto MO 249
3.4 mi·3 min·Governor Warren E Hearnes Memorial Highway
Toward MO 249 South: Joplin
7
Take the exit
0.3 mi·38 sec
Toward MO 66, I 44 Business
8
Turn left onto I 44 Business; MO 66
2.0 mi·3 min·East 7th Street
9
Continue on I 44 Business; MO 66
0.9 mi·1 min·Cimarron Road
10
Take the ramp onto I 44 Business
0.6 mi·1 min·I 44 Business
Toward I 44 East, I 49 North, US 71 North: Springfield, Kansas City
11
Merge onto I 44; I 49; US 71
53 mi·57 min·Congressman Gene Taylor Highway
Use the straight / slight right lanes.
12
Take the exit
0.3 mi·31 sec
Exit 69Toward MO 360 East
13
Continue on MO 360
14 mi·16 min·James River Freeway
14
Continue on US 60
81 mi·1 hr 34 min·US 60
15
Keep slight left at fork onto US 60
90 mi·1 hr 46 min·US 60
Toward US 60 East: Mountain View, Poplar Bluff
16
Keep slight right at fork onto US 60
4.8 mi·6 min·US 60
17
Turn straight onto US 60 Business; US 67 Business
0.2 mi·14 sec·North Westwood Boulevard
18
Turn slight left
274 ft·12 sec
19
Turn left onto MO W
0.1 mi·16 sec·MO W
20
Take the ramp
0.2 mi·26 sec
21
Merge onto US 60
51 mi·58 min·US 60
22
Take the exit
0.3 mi·43 sec
Exit 1BToward I 55 North: Saint Louis
23
Merge onto I 55
27 mi·29 min·I 55
24
Keep slight right at fork onto US 61
2.0 mi·2 min·US 61
Exit 93BToward US 61, I 55 Business: Cape Girardeau
25
Turn right onto MO 34; MO 74
1.6 mi·2 min·Shawnee Parkway
Use the left lane.
26
Turn left onto MO 177
0.8 mi·1 min·South Sprigg Street
Use the left lane.
27
Turn right onto Broadway Street
0.5 mi·50 sec·Broadway Street
28
Arrive at destination
Broadway Street
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 168.8 miles from Webb City, MO, or about 3h 14m into the drive.
The longest continuous stretch on this route runs about 227.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 74 miles or 1h 23m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 168.8 miles or 3h 14m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 23m
Traffic, exits, and arrival timing usually matter more near Cape Girardeau, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Webb City, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Webb City, MO
This is one driving day of about 337.6 miles and 6h 33m.
Your first comfortable stop window is around 74 miles from Webb City, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 60 for about 227.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 168.8 mi from Webb City, MO
· 3h 14m into the drive
The midpoint is around 170.1 miles from Webb City, MO, which is a good place for a longer meal and fuel stop.
Arriving in Cape Girardeau, MO
The final approach into Cape Girardeau, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Cape Girardeau, MO.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Wilson's Creek National Battlefield
National Battlefield
Wilson's Creek was the first major Civil War battle fought west of the Mississippi River, and where the first Union general was killed in action. The costly Southern victory on August 10, 1861, focuse...
5 mi from route
~13 min detour
Free
near mile 69.9
The young child known as the "Plant Doctor" tended his secret garden while observing the day-to-day operations of a 19th century farm. Nature and nurture ultimately influenced George on his quest for...
7 mi from route
~17 min detour
Free
near mile 11.6
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$52.78 one way
$105.56 round trip
$3.97/gal25.4 MPG avg118 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$57.95
$115.90
premium
$4.89
$64.97
$129.94
diesel
$5.61
$74.54
$149.08
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$53
Meals
$25–$50
Total
$78–$103
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 118.1 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $35 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
101.3
1
$35.45
$16.20
Efficient EV
84.4
0
$29.54
$13.50
EV Truck/SUV
135
1
$47.26
$21.61
Gas CO2
118 kg
EV CO2
39 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Webb City, MO
Morning
in Webb City on Friday
Local time
8:58 AM
CDT
Current temp
57°F
Unavailable
Live forecast
Destination
Cape Girardeau, MO
Morning
in Cape Girardeau on Friday
Local time
8:58 AM
CDT
Current temp
81°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
24 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 33m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Webb City, MO to Cape Girardeau, MO covers 337.6 miles and takes about 6h 33m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 60, Congressman Gene Taylor Highway, I 55. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 168.8 miles from Webb City, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $52.78 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 19 significant decision points across 337.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 0.7 miles (I 49 Business; MO 171): Roundabout - know your exit number before entering; at 5.3 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 158.3 miles (US 60): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
On the drive from Webb City, MO to Cape Girardeau, MO, road signs begin pointing toward Poplar Bluff along the way.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
