Overnight Road Trips from Independence, MO
Routes
9
Avg Distance
362 mi
Avg Drive
7h 1m
Destinations
9
Independence, MO is a launching point for 6 routes that deserve more than one day. Plan an overnight stop, explore a midway town, and arrive at your destination rested and ready.
Planning Tips
- Book accommodation in the suggested stop town — it breaks the drive naturally and gives you a reason to explore.
- Pack an overnight bag that's easy to grab from the car without unpacking everything.
- Split long drives so the hardest stretch is the first day when you're freshest.
Frequently Asked Questions
6 routes from Independence, MO are recommended as multi-day trips — typically 4+ hours of driving with suggested overnight stop towns along the way.
Drive times and distances come from actual road network data via OSRM. Fuel costs use current state-level gas prices. Drive scores factor in elevation profile, road variety, and terrain. All data is recalculated regularly.
Yes. Click any route to see its full trip page with turn-by-turn directions, fuel cost estimates, elevation profile, stop suggestions, weather conditions, and more.
Multi-Day Routes
Independence, MO → Potosi, MO
261.6 mi
5h 25m
Score: 9/10
1-day trip
Independence, MO → West Plains, MO
281 mi
5h 33m
Score: 8/10
1-day trip
Independence, MO → Perryville, MO
306.6 mi
5h 53m
Score: 8/10
1-day trip
Independence, MO → Advance, MO
365.5 mi
7h
Score: 8/10
1-day trip
Independence, MO → Bernie, MO
403.2 mi
7h 39m
Score: 8/10
1-day trip
Independence, MO → Campbell, MO
389 mi
7h 48m
Score: 8/10
1-day trip
Independence, MO → Malden, MO
411.2 mi
7h 52m
Score: 8/10
1-day trip
Independence, MO → Caruthersville, MO
421.6 mi
7h 56m
Score: 8/10
1-day trip
Independence, MO → Glendale, MO
418.4 mi
8h 7m
Score: 7/10
2-day trip