Trip from Independence, MO to Perryville, MO

Drive Time

5h 53m

Distance

306.6 mi

494 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$47

one way

Best Time Drive vs Fly

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Independence, MO

Ever Rayan

Perryville, MO

Valeria Boltneva

Trip Overview

Connecting Independence to Perryville, this 306.6-mile journey across Missouri takes approximately 5 hours and 53 minutes of driving time. Because the route is categorized as a turn-heavy local drive, it is best suited for a single-day trip rather than an overnight split. You should budget roughly $47 for fuel to complete the trek. Navigating through the Midwest, your path is defined by a mix of major thoroughfares, including the Dwight D. Eisenhower Highway, the Police Officer Steven Jarvis Memorial Highway, and the U.S. Submarine Veterans' Memorial Highway. This route offers a straightforward, practical way to traverse the state, provided you are prepared for the local road conditions.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

153.3 miles from Independence, MO

A natural place for your longest stop of the day , about 2h 52m into the drive .

Drive Character

Expect a varied experience behind the wheel, as this journey is not a simple interstate cruise. Only 6% of the travel is highway-based, meaning you will spend the vast majority of your time on local roads that demand more focus than a typical high-speed corridor. The longest uninterrupted stretch you will encounter is 135.3 miles on the Dwight D. Eisenhower Highway, which provides a brief reprieve from the more technical sections. As you transition between these road types, the personality of the drive shifts from major highway corridors to more winding local paths. Stay alert, as the turn-heavy nature of the route keeps the drive engaging throughout the trip.

This route has more turning and local-road decision points than a simple highway run.

There are about 32 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

Dwight D. Eisenhower Highway is the longest continuous segment at about 135.3 miles.

How Hard Is This Drive?

Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.2 miles in near South Noland Road.

Route Complexity 10/10

High effort - long or complex enough to need steady focus all day

This is a demanding drive. With 20 significant decision points across 306.6 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 0.2 miles (South Noland Road): Lane positioning matters here; at 3.3 miles: Multiple destination signs - pick the right one; at 226.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.

Critical Maneuvers

5 of 20 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

0.2 mi into trip | ~0m in | South Noland Road

Turn right onto South Noland Road

Lane positioning matters here

Use the none lane.

3.3 mi into trip | ~6m in

Turn left toward I 70 East: Columbia, Saint Louis

Multiple destination signs - pick the right one

Toward I 70 East: Columbia, Saint Louis

226.2 mi into trip | ~4h 19m in

Take the exit toward I 270: Chicago, Memphis

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 25 Toward I 270: Chicago, Memphis

226.5 mi into trip | ~4h 19m in

Keep slight right at fork toward I 270 South: Memphis

Highway fork - watch signs carefully. Lane positioning matters here

Use the slight right lane. Toward I 270 South: Memphis

238.3 mi into trip | ~4h 34m in

Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the straight / slight right lanes. Exit 1A Toward I 55, US 61, US 67: Saint Louis, Memphis...

Towns Along This Route

On the drive from Independence, MO to Perryville, MO, road signs begin pointing toward Memphis along the way.

Memphis

226.2 mi in | ~4h 19m

Main Roads

Road	Distance	Duration
Dwight D. Eisenhower Highway	135.3 mi	2h 34m
Police Officer Steven Jarvis Memorial Highway	57.5 mi	1h 1m
U.S. Submarine Veterans' Memorial Highway	54.4 mi	58m
Avenue of the Saints	25.1 mi	30m
I 270	11.5 mi	14m
US 61	5.3 mi	7m
South Noland Road	3.1 mi	5m
Truman/Eisenhower Presidential Highway	2.6 mi	3m

Longest stretch: Dwight D. Eisenhower Highway — 135.3 mi, about 2h 34m

Turn-by-Turn Driving Directions

Step-by-step road directions between Independence, MO and Perryville, MO.

Start on East Kansas Avenue

145 ft · 8 sec · East Kansas Avenue

Turn right onto South Lynn Street

394 ft · 22 sec · South Lynn Street

Turn left onto East Walnut Street

466 ft · 25 sec · East Walnut Street

Turn right onto South Noland Road

3.1 mi · 5 min · South Noland Road

Use the none lane.

Turn left

0.2 mi · 26 sec

Toward I 70 East: Columbia, Saint Louis

Merge onto I 70

1.5 mi · 1 min · Clifton J. Scott Memorial Highway

Continue on I 70

2.6 mi · 3 min · Truman/Eisenhower Presidential Highway

Use the none lane.

Continue on I 70

53 mi · 56 min · Dwight D. Eisenhower Highway

Use the none lane.

Continue on I 70; US 40

32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway

Keep slight left at fork onto I 70

22 mi · 24 min · U.S. Submarine Veterans' Memorial Highway

Continue on I 70; US 40

1.8 mi · 2 min · Dwight D. Eisenhower Highway

Continue on I 70; US 40

1.6 mi · 1 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway

Continue on I 70; US 40

1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway

Continue on I 70; US 40

81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway

Take the exit onto US 40

0.3 mi · 33 sec · US 40

Exit 210A Toward I 64 East, US 40 East, US 61 South: Chesterfield

Merge onto I 64; US 40; US 61

25 mi · 30 min · Avenue of the Saints

Use the straight / slight left lanes.

Take the exit

0.3 mi · 38 sec

Exit 25 Toward I 270: Chicago, Memphis Use the slight right lane.

Keep slight right at fork

0.3 mi · 31 sec

Toward I 270 South: Memphis Use the slight right lane.

Merge onto I 270

11 mi · 14 min · I 270

Use the none lane.

Take the exit

0.4 mi · 27 sec

Exit 1A Toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road Use the straight / slight right lanes.

Keep slight right at fork

0.4 mi · 43 sec

Toward I 55 South: Memphis

Merge onto I 55

1.5 mi · 1 min · Rosa Parks Highway

Use the none lane.

Continue on I 55

1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway

Use the none lane.

Continue on I 55

57 mi · 1 hr 1 min · Police Officer Steven Jarvis Memorial Highway

Use the none lane.

Take the exit

0.2 mi · 29 sec

Exit 135 Toward MO M: Brewer

Turn left onto MO M

0.6 mi · 1 min · MO M

At end of road, turn right onto US 61; MO M

5.3 mi · 7 min · US 61; MO M

Enter roundabout onto MO B

55 ft · 0 sec · North Main Street

Continue on MO B

0.5 mi · 1 min · North Main Street

Turn left onto East Saint Joseph Street

365 ft · 18 sec · East Saint Joseph Street

Turn right onto South Spring Street

221 ft · 9 sec · South Spring Street

Arrive at destination

South Spring Street

Trip Plan

To make the most of your 306.6-mile journey, aim for an early morning departure to account for the local road segments that can slow your progress. With only one recommended stop, plan your break strategically to coincide with the end of your longest stretch on the Dwight D. Eisenhower Highway. Since fuel costs hover around $47, check your tank before leaving Independence to avoid unnecessary mid-trip fill-ups. The primary advantage of this route is its flexibility, but keep in mind that the local road intensity requires constant attention to navigation. Prioritize a steady pace to ensure you reach Perryville comfortably before sunset.

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 153.3 miles from Independence, MO, or about 2h 52m into the drive.

The longest continuous stretch on this route runs about 135.3 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 29m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 153.3 miles or 2h 52m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 4h 49m

Traffic, exits, and arrival timing usually matter more near Perryville, MO than in the middle of the route.

Before You Leave

Open the route before leaving Independence, MO so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Independence, MO

This is one driving day of about 306.6 miles and 5h 53m.

Your first comfortable stop window is around 80 miles from Independence, MO.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 153.3 mi from Independence, MO · 2h 52m into the drive

Mid-route town

Meal stop

Alton, IL

153 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Kansas City, MO

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Quincy, IL

Meal break

The midpoint is around 153.3 miles from Independence, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before Dwight D. Eisenhower Highway if your tank is already low. That segment runs about 135.3 miles.

Arriving in Perryville, MO

The final approach into Perryville, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Perryville, MO.

After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$46.57 one way

$93.14 round trip

$3.86/gal 25.4 MPG avg 107 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.25	$51.34	$102.67
premium	$4.80	$57.88	$115.76
diesel	$5.64	$68.12	$136.23

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$47

Meals

$25–$50

Total

$72–$97

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 107.3 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $32 in charging · 1 stop · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	92	1	$32.19	$14.72
Efficient EV	76.7	0	$26.83	$12.26
EV Truck/SUV	122.6	1	$42.92	$19.62

Gas CO2

107 kg

EV CO2

36 kg (66% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 2 days ago

Origin

Independence, MO

Afternoon in Independence on Sunday

Local time

2:22 PM

CDT

Current temp

49°F

Unavailable

Live forecast

Destination

Perryville, MO

Afternoon in Perryville on Sunday

Local time

2:22 PM

CDT

Current temp

79°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

30 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

5h 53m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Independence, MO to Perryville, MO covers 306.6 miles and takes about 5h 53m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are Dwight D. Eisenhower Highway, Police Officer Steven Jarvis Memorial Highway, U.S. Submarine Veterans' Memorial Highway. Expect a mix of highway and local road driving.

This is a comfortable same-day trip.

The midpoint is about 153.3 miles from Independence, MO. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $46.57 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.

Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

On the drive from Independence, MO to Perryville, MO, road signs begin pointing toward Memphis along the way.

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Return Trip

Perryville, MO to Independence, MO

Plan the drive back the other way.

306.9 mi 5h 54m

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Trip from Independence, MO to Perryville, MO

Trip Overview

Drive Character

How Hard Is This Drive?

Critical Maneuvers

Towns Along This Route

Main Roads

Turn-by-Turn Driving Directions

Trip Plan

Before You Leave

Where to Stop

Pacing Suggestions

Arriving in Perryville, MO

Fuel & Cost

Travel Intel

Independence, MO

Perryville, MO

Same local time

30 degrees warmer at arrival

5h 53m on the road

Frequently Asked Questions

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