The drive from Aberdeen, MS to Biloxi, MS covers 282.2 miles and takes about 5h 29m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 45, I 59, US 49 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 108.6 miles on US 45.
At current regular gas prices, budget about $42.62 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
141.1 miles from Aberdeen, MS
A natural place for your longest stop of the day
, about 2h 45m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 29m. Total distance: 282.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 29m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (97%). Some complex stretches to watch for.
Drive Character
This is a 5h 29m highway drive covering 282.2 miles, with most of the trip on US 45 and I 59. The longest continuous stretch is about 108.6 miles on US 45.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 35 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 45 is the longest continuous segment at about 108.6 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 45 and I 59. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 30.7 miles in near US 45.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 282.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 30.7 miles (US 45): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 122.1 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 210.8 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 18 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
7
30.7 mi into trip|~39m in|US 45
Keep slight left at fork onto US 45 toward US 45 South: Macon, Meridian
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 45 South: Macon, Meridian
8
122.1 mi into trip|~2h 25m in|I 59
Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 59 South: Laurel, New Orleans
7
210.8 mi into trip|~4h 1m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
214 mi into trip|~4h 5m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
214.3 mi into trip|~4h 6m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Aberdeen, MS and Biloxi, MS, road signs point toward Meridian, New Orleans, Mobile, Gulfport, Mississippi Gulf Coast and Multi Purpose Center - among others.
Meridian
30.5 mi in|~38m|via US 45
New Orleans
122.1 mi in|~2h 25m|via I 59
Mobile
210.8 mi in|~4h 1m|via US 98
Gulfport
214 mi in|~4h 5m
Mississippi Gulf Coast
214 mi in|~4h 5m
Multi Purpose Center
214.3 mi in|~4h 6m
Hattiesburg
214.3 mi in|~4h 6m
Main Roads
Road
Distance
Duration
US 45
108.6 mi
2h 7m
I 59
88.7 mi
1h 36m
US 49
41.9 mi
49m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
I 20
8.1 mi
9m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
East Commerce Street
1.2 mi
2m
Longest stretch:
US 45
— 108.6 mi, about 2h 7m
Turn-by-Turn Driving Directions
Step-by-step road directions between Aberdeen, MS and Biloxi, MS.
1
Start on South Meridian Street
80 ft·5 sec·South Meridian Street
2
Turn right onto MS 145
1.2 mi·2 min·East Commerce Street
3
At end of road, turn left onto US 45; MS 8; MS 25
2.8 mi·3 min·US 45; MS 8; MS 25
4
Continue on US 45
0.8 mi·52 sec·US 45
5
Continue on US 45
2.2 mi·2 min·US 45
6
Continue on US 45
2.6 mi·3 min·US 45
7
Continue on US 45
3.9 mi·4 min·US 45
8
Continue on US 45
0.6 mi·44 sec·US 45
9
Continue on US 45
1.9 mi·2 min·US 45
10
Continue on US 45
0.4 mi·27 sec·US 45
11
Continue on US 45
1.8 mi·2 min·US 45
12
Continue on US 45
7.8 mi·10 min·US 45
13
Continue on US 45; MS 50
0.8 mi·1 min·US 45; MS 50
Use the left lane.
14
Take the exit
3.7 mi·4 min
15
Take the exit onto US 45
0.2 mi·43 sec·US 45
Toward US 45 South: Macon, Meridian
16
Keep slight left at fork onto US 45
135 ft·7 sec·US 45
Toward US 45 South: Macon, Meridian
17
Turn left onto US 45
15 mi·16 min·US 45
Use the left / straight lanes.
18
Continue on US 45
64 mi·1 hr 13 min·US 45
19
Keep slight right at fork onto US 45
3.9 mi·4 min·US 45
20
Take the exit
0.5 mi·1 min
Toward I 59 South, I 20 West: Meridian
21
Merge onto I 20; I 59
6.3 mi·7 min·I 20; I 59
Use the straight / slight right lanes.
22
Continue on I 20; I 59; US 80
1.8 mi·2 min·I 20; I 59; US 80
Use the straight lane.
23
Keep slight left at fork onto I 59
89 mi·1 hr 36 min·I 59
Toward I 59 South: Laurel, New OrleansUse the slight left / slight right lanes.
24
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
25
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
26
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
27
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
28
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
29
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
30
Continue on I 110
3.2 mi·4 min·I 110
31
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
32
Turn left onto Division Street
0.6 mi·1 min·Division Street
33
Turn right onto Main Street
0.5 mi·1 min·Main Street
34
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
35
Arrive at destination
Howard Avenue
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 141.1 miles from Aberdeen, MS, or about 2h 45m into the drive.
The longest continuous stretch on this route runs about 108.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 62 miles or 1h 15m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 141.1 miles or 2h 45m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 26m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Aberdeen, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Aberdeen, MS
This is one driving day of about 282.2 miles and 5h 29m.
Your first comfortable stop window is around 62 miles from Aberdeen, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 45 for about 108.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 141.1 mi from Aberdeen, MS
· 2h 45m into the drive
Place data sourced from public business listings. Hours and availability may vary.
Fuel & Cost
Regular Gas
$42.62 one way
$85.24 round trip
$3.84/gal25.4 MPG avg99 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$46.79
$93.57
premium
$4.56
$50.65
$101.30
diesel
$5.61
$62.31
$124.61
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$43
Meals
$25–$50
Total
$68–$93
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 98.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
9 DC fast chargers
· Coverage: excellent
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Eaton Charging Station
Ocean Springs, Mississippi
Other
1 DCFC
ChargePoint Charging Station
D'Iberville, Mississippi
ChargePoint
1 DCFC
Other: 4
Tesla Destination: 4
ChargePoint: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $30 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
84.7
1
$29.63
$13.55
Efficient EV
70.6
0
$24.69
$11.29
EV Truck/SUV
112.9
1
$39.51
$18.06
Gas CO2
99 kg
EV CO2
33 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Aberdeen, MS
Afternoon
in Aberdeen on Thursday
Local time
4:17 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Biloxi, MS
Afternoon
in Biloxi on Thursday
Local time
4:17 PM
CDT
Current temp
61°F
Unavailable
Live forecast
79°F
Meridian, MS
141 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 29m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Aberdeen, MS to Biloxi, MS covers 282.2 miles and takes about 5h 29m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 45, I 59, US 49. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 141.1 miles from Aberdeen, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $42.62 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 18 significant decision points across 282.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 30.7 miles (US 45): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 122.1 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 210.8 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Aberdeen, MS and Biloxi, MS, road signs point toward Meridian, New Orleans, Mobile, Gulfport, Mississippi Gulf Coast and Multi Purpose Center - among others.
