The drive from Greenwood, MS to Biloxi, MS covers 321.4 miles and takes about 6h 26m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 59, US Highway 45 Aiternate, US Highway 45 Alternate for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 88.7 miles on I 59.
At current regular gas prices, budget about $48.54 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
160.7 miles from Greenwood, MS
A natural place for your longest stop of the day
, about 3h 21m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 26m. Total distance: 321.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 26m drive, plan rest stops for pacing.
Drive Character
This is a 6h 26m highway drive covering 321.4 miles, with most of the trip on I 59 and US Highway 45 Aiternate. The longest continuous stretch is about 88.7 miles on I 59.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 34 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 59 is the longest continuous segment at about 88.7 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 59 and US Highway 45 Aiternate. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 161.3 miles in near I 59.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 321.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 161.3 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 250 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 253.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 19 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
8
161.3 mi into trip|~3h 22m in|I 59
Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 59 South: Laurel, New Orleans
7
250 mi into trip|~4h 58m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
253.2 mi into trip|~5h 2m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
253.5 mi into trip|~5h 2m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
6
253.6 mi into trip|~5h 3m in|US 49
Turn right onto US 49
Lane positioning matters here
Use the straight lane.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Greenwood, MS and Biloxi, MS, road signs point toward New Orleans, Mobile, Gulfport, Mississippi Gulf Coast, Multi Purpose Center and Hattiesburg.
New Orleans
161.3 mi in|~3h 22m|via I 59
Mobile
250 mi in|~4h 58m|via US 98
Gulfport
253.2 mi in|~5h 2m
Mississippi Gulf Coast
253.2 mi in|~5h 2m
Multi Purpose Center
253.5 mi in|~5h 2m
Hattiesburg
253.5 mi in|~5h 2m
Main Roads
Road
Distance
Duration
I 59
88.7 mi
1h 36m
US Highway 45 Aiternate
60.6 mi
1h 9m
US Highway 45 Alternate
54.7 mi
1h 6m
US 49
41.9 mi
49m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
MS 178
11.8 mi
17m
Martin Luther King Drive
8.7 mi
10m
I 20
8.1 mi
9m
Longest stretch:
I 59
— 88.7 mi, about 1h 36m
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenwood, MS and Biloxi, MS.
1
Start on Greenwood Hopewell Road
145 ft·7 sec·Greenwood Hopewell Road
2
Turn left onto Dorsey Evergreen Road
428 ft·18 sec·Dorsey Evergreen Road
3
Keep slight right at fork onto Dorsey Evergreen Road
2.4 mi·9 min·Dorsey Evergreen Road
4
At end of road, turn right onto Bankhead Road Southwest
0.1 mi·26 sec·Bankhead Road Southwest
5
Turn left onto Dorsey Evergreen Road
0.4 mi·1 min·Dorsey Evergreen Road
6
Turn left onto MS 178
12 mi·17 min·MS 178
Use the straight lane.
7
Turn left onto MS 6
0.4 mi·55 sec·MS 6
Use the left lane.
8
Merge onto US 45; MS 6
1.0 mi·1 min·Martin Luther King Drive
9
Continue on US 45; MS 6
2.3 mi·2 min·Martin Luther King, Junior Drive
10
Continue on US 45; US 278
7.7 mi·8 min·Martin Luther King Drive
11
Continue on US 45 ALT
1.4 mi·1 min·US 45 ALT
12
Continue on US 45 ALT
2.2 mi·2 min·US 45 ALT
13
Continue on US 45 ALT
1.5 mi·1 min·US 45 ALT
14
Continue on US 45 ALT
0.7 mi·49 sec·US 45 ALT
15
Continue on US 45 ALT
1.4 mi·1 min·US 45 ALT
16
Continue on US 45 ALT
55 mi·1 hr 6 min·US Highway 45 Alternate
Use the straight lane.
17
Continue on US 45
61 mi·1 hr 9 min·US Highway 45 Aiternate
18
Keep slight right at fork onto US 45
3.9 mi·4 min·US 45
19
Take the exit
0.5 mi·1 min
Toward I 59 South, I 20 West: Meridian
20
Merge onto I 20; I 59
6.3 mi·7 min·I 20; I 59
Use the straight / slight right lanes.
21
Continue on I 20; I 59; US 80
1.8 mi·2 min·I 20; I 59; US 80
Use the straight lane.
22
Keep slight left at fork onto I 59
89 mi·1 hr 36 min·I 59
Toward I 59 South: Laurel, New OrleansUse the slight left / slight right lanes.
23
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
24
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
25
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
26
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
27
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
28
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
29
Continue on I 110
3.2 mi·4 min·I 110
30
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
31
Turn left onto Division Street
0.6 mi·1 min·Division Street
32
Turn right onto Main Street
0.5 mi·1 min·Main Street
33
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
34
Arrive at destination
Howard Avenue
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 160.7 miles from Greenwood, MS, or about 3h 21m into the drive.
The longest continuous stretch on this route runs about 88.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 71 miles or 1h 36m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 160.7 miles or 3h 21m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 14m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenwood, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenwood, MS
This is one driving day of about 321.4 miles and 6h 26m.
Your first comfortable stop window is around 71 miles from Greenwood, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 59 for about 88.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 160.7 mi from Greenwood, MS
· 3h 21m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Natchez Trace National Scenic Trail
National Scenic Trail
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
6 mi from route
~16 min detour
Free
near mile 11.1
Park Closure: Partial Closure of Rocky Springs Trail
Park Closure: Temporary Blackland Prairie Trail Closure to Equestrians
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
6 mi from route
~15 min detour
Free
near mile 11.1
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$48.54 one way
$97.08 round trip
$3.84/gal25.4 MPG avg113 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$53.28
$106.57
premium
$4.56
$57.69
$115.38
diesel
$5.61
$70.96
$141.92
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$49
Meals
$25–$50
Total
$74–$99
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 112.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
8 DC fast chargers
· Coverage: good
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Eaton Charging Station
Ocean Springs, Mississippi
Other
1 DCFC
ChargePoint Charging Station
D'Iberville, Mississippi
ChargePoint
1 DCFC
Tesla Destination: 4
Other: 3
ChargePoint: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $34 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
96.4
1
$33.75
$15.43
Efficient EV
80.4
0
$28.12
$12.86
EV Truck/SUV
128.6
1
$45.00
$20.57
Gas CO2
112 kg
EV CO2
38 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Greenwood, MS
Night
in Greenwood on Thursday
Local time
10:17 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Biloxi, MS
Night
in Biloxi on Thursday
Local time
10:17 PM
CDT
Current temp
61°F
Unavailable
Live forecast
79°F
Meridian, MS
161 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 26m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Greenwood, MS to Biloxi, MS covers 321.4 miles and takes about 6h 26m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 59, US Highway 45 Aiternate, US Highway 45 Alternate. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 160.7 miles from Greenwood, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $48.54 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 19 significant decision points across 321.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 161.3 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 250 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 253.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Greenwood, MS and Biloxi, MS, road signs point toward New Orleans, Mobile, Gulfport, Mississippi Gulf Coast, Multi Purpose Center and Hattiesburg.
