The drive from Biddeford, ME to Guilford, ME covers 145.2 miles and takes about 2h 56m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Maine Turnpike, I 295, North Dexter Road for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 62.3 miles on Maine Turnpike.
At current regular gas prices, budget about $23.37 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
72.6 miles from Biddeford, ME
A natural place for your longest stop of the day
, about 1h 25m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 2h 56m. Total distance: 145.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
2h 56m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (79%). Some complex stretches to watch for.
Drive Character
This is a 2h 56m highway drive covering 145.2 miles, with most of the trip on Maine Turnpike and I 295. The longest continuous stretch is about 62.3 miles on Maine Turnpike.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 25 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Maine Turnpike is the longest continuous segment at about 62.3 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on Maine Turnpike and I 295. You will hit about 11 points where you need to pay attention to lane position or signs. The trickiest moment comes around 2.3 miles in.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 145.2 miles you will encounter 11 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 2.3 miles: Navigation decision point; at 11.6 miles (I 295): Highway fork - watch signs carefully. Lane positioning matters here; at 117.7 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 11 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
4
2.3 mi into trip|~4m in
Take the ramp toward I 95 North: Portland
Navigation decision point
Toward I 95 North: Portland
8
11.6 mi into trip|~14m in|I 295
Keep slight right at fork onto I 295 toward Downtown Portland
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Exit 44
Toward Downtown Portland
6
117.7 mi into trip|~2h 14m in
Take the exit toward ME 11, ME 100: Newport, Dexter
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 157
Toward ME 11, ME 100: Newport, Dexter
5
118 mi into trip|~2h 15m in
Keep slight left at fork
Highway fork - watch signs carefully
4
118.5 mi into trip|~2h 16m in|ME 7; ME 11 / Moosehead Trail
Enter roundabout onto ME 7; ME 11 / Moosehead Trail
Roundabout - know your exit number before entering
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biddeford, ME and Guilford, ME, road signs point toward Portland and Dexter.
Portland
11.6 mi in|~14m|via I 295
Dexter
117.7 mi in|~2h 14m
Main Roads
Road
Distance
Duration
Maine Turnpike
62.3 mi
1h 7m
I 295
52.5 mi
1h 1m
North Dexter Road
9.4 mi
14m
Dexter Road
5.9 mi
8m
Moosehead Trail
4.7 mi
7m
Main Street
1.7 mi
2m
Newport Road
1.4 mi
2m
North Street
1.4 mi
2m
Longest stretch:
Maine Turnpike
— 62.3 mi, about 1h 7m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biddeford, ME and Guilford, ME.
1
Start on US 1 Alternate
0.9 mi·1 min·Main Street
2
Turn left onto ME 112
162 ft·5 sec·Beach Street
3
Continue on ME 5; ME 112
1.4 mi·2 min·North Street
4
Take the ramp
0.6 mi·1 min
Toward I 95 North: Portland
5
Merge onto I 95
8.8 mi·9 min·Maine Turnpike
6
Keep slight right at fork onto I 295
52 mi·1 hr 1 min·I 295
Exit 44Toward Downtown PortlandUse the slight right lane.
7
Merge onto I 95
54 mi·58 min·Maine Turnpike
8
Take the exit
0.3 mi·46 sec
Exit 157Toward ME 11, ME 100: Newport, Dexter
9
Keep slight left at fork
112 ft·6 sec
10
Turn left onto ME 11; ME 100
0.5 mi·1 min·Ox Bow Road
11
Enter roundabout onto ME 7; ME 11
120 ft·2 sec·Moosehead Trail
12
Continue on ME 7; ME 11
4.7 mi·6 min·Moosehead Trail
13
Continue on ME 7; ME 11
1.4 mi·2 min·Newport Road
14
Continue on ME 7; ME 11; ME 43
5.9 mi·8 min·Dexter Road
15
Continue on ME 7
1.2 mi·1 min·Corinna Road
16
Continue on ME 7
1.0 mi·1 min·Spring Street
17
Continue on Church Street
0.2 mi·21 sec·Church Street
18
Turn left onto ME 23
290 ft·4 sec·Dam Street
19
Continue on ME 23
0.6 mi·52 sec·Grove Street
20
Continue on Crockett Road
418 ft·7 sec·Crockett Road
21
Turn straight onto ME 23
9.4 mi·14 min·North Dexter Road
22
Continue on ME 23
0.8 mi·1 min·Main Street
23
Continue on ME 23
0.1 mi·18 sec·Bridge Street
24
Turn left onto ME 6; ME 15; ME 16
1.2 mi·1 min·Water Street
25
Arrive at destination
ME 6; ME 15; ME 16; ME 150
Trip Plan
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 72.6 miles from Biddeford, ME, or about 1h 25m into the drive.
The longest continuous stretch on this route runs about 62.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 32 miles or 38m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 72.6 miles or 1h 25m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 17m
Traffic, exits, and arrival timing usually matter more near Guilford, ME than in the middle of the route.
Before You Leave
+
Open the route before leaving Biddeford, ME so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biddeford, ME
This is one driving day of about 145.2 miles and 2h 56m.
Your first comfortable stop window is around 32 miles from Biddeford, ME.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Maine Turnpike for about 62.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 72.6 mi from Biddeford, ME
· 1h 25m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Frances Perkins National Monument
National Monument
Known as the first woman to hold a presidential cabinet position and the “Woman behind the New Deal,” Frances Perkins championed many labor rights that Americans enjoy today, including safety standard...
17 mi from route
~42 min detour
Free
near mile 55.1
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$23.37 one way
$46.75 round trip
$4.09/gal25.4 MPG avg51 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.50
$25.72
$51.44
premium
$4.86
$27.81
$55.61
diesel
$5.61
$32.06
$64.12
Estimated Tolls: $3.74
Maine Turnpike
(62.3 mi)$3.74
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$23
Tolls
$4
Meals
$25–$50
Total
$52–$77
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 50.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $15 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
43.6
0
$15.25
$6.97
Efficient EV
36.3
0
$12.70
$5.81
EV Truck/SUV
58.1
0
$20.33
$9.29
Gas CO2
51 kg
EV CO2
17 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
Biddeford, ME
Morning
in Biddeford on Friday
Local time
10:48 AM
EDT
Current temp
53°F
Unavailable
Live forecast
Destination
Guilford, ME
Morning
in Guilford on Friday
Local time
10:48 AM
EDT
Current temp
53°F
Unavailable
Live forecast
46°F
Brunswick, ME
73 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
2h 56m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Biddeford, ME to Guilford, ME covers 145.2 miles and takes about 2h 56m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Maine Turnpike, I 295, North Dexter Road. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 72.6 miles from Biddeford, ME. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $23.37 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Leave by 9 AM and you'll arrive before lunch. Even a 4 PM departure gets you there before dark in summer.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
This drive requires moderate attention. Across 145.2 miles you will encounter 11 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: at 2.3 miles: Navigation decision point; at 11.6 miles (I 295): Highway fork - watch signs carefully. Lane positioning matters here; at 117.7 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Between Biddeford, ME and Guilford, ME, road signs point toward Portland and Dexter.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
