The drive from Biloxi, MS to Greenwood, MS covers 309.3 miles and takes about 6h 25m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 45, Lance Corporal Roy M Wheat Memorial Highway, US 49 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 106.1 miles on US 45.
At current regular gas prices, budget about $46.71 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
154.7 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 2h 58m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 25m. Total distance: 309.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 25m drive, plan rest stops for pacing.
Drive Character
This is a 6h 25m highway drive covering 309.3 miles, with most of the trip on US 45 and Lance Corporal Roy M Wheat Memorial Highway. The longest continuous stretch is about 106.1 miles on US 45.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 40 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 45 is the longest continuous segment at about 106.1 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 45 and Lance Corporal Roy M Wheat Memorial Highway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 23 significant decision points across 309.3 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 23 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
7
70.4 mi into trip|~1h 26m in|US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
159.6 mi into trip|~3h 3m in|I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
6
168.6 mi into trip|~3h 14m in
Take the exit toward US 45 North: Macon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Toward US 45 North: Macon
6
234 mi into trip|~4h 29m in|US 45
Keep slight right at fork onto US 45 toward US 45 North: Columbus, Aberdeen
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 45 North: Columbus, Aberdeen
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Greenwood, MS, road signs point toward Jackson, Laurel, Tuscaloosa and Aberdeen.
Jackson
25.1 mi in|~32m
Laurel
70.4 mi in|~1h 26m|via US 98
Tuscaloosa
159.6 mi in|~3h 3m|via I 59
Aberdeen
234 mi in|~4h 29m|via US 45
Main Roads
Road
Distance
Duration
US 45
106.1 mi
2h 4m
Lance Corporal Roy M Wheat Memorial Highway
88.4 mi
1h 35m
US 49
42.2 mi
49m
MS 15
20.7 mi
24m
State Highway 371
10.1 mi
17m
I 59
9 mi
10m
MS 8
6.5 mi
9m
Highway 125
5.2 mi
9m
Longest stretch:
US 45
— 106.1 mi, about 2h 4m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Greenwood, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Take the exit
0.3 mi·51 sec
12
Merge onto US 98
2.5 mi·2 min·US 98
Use the straight / slight right lanes.
13
Take the exit onto US 98
0.8 mi·1 min·US 98
Toward I 59 North, US 98 West: Columbia, LaurelUse the straight / slight right lanes.
14
Merge onto I 59; US 98
88 mi·1 hr 35 min·Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
15
Keep slight right at fork onto I 59
9.0 mi·10 min·I 59
Toward I 59 North, I 20 East: Meridian, TuscaloosaUse the straight lane.
16
Take the exit
0.3 mi·47 sec
Toward US 45 North: MaconUse the slight right lane.
17
Merge onto US 45
65 mi·1 hr 14 min·US 45
Use the straight lane.
18
Keep slight right at fork onto US 45
3.4 mi·4 min·US 45
Toward US 45 North: Columbus, Aberdeen
19
Continue on US 45
14 mi·16 min·US 45
20
Continue on Plymouth Bluff Access Road
312 ft·5 sec·Plymouth Bluff Access Road
Use the straight / slight right lanes.
21
Take the exit
3.9 mi·4 min
Toward US 82 East, US 45 North, MS 12 East: Columbus
22
Take the exit onto US 45
0.5 mi·55 sec·US 45
Toward US 45 North: AberdeenUse the slight right lane.
23
Continue on US 45; MS 50
13 mi·16 min·US 45; MS 50
Use the left lane.
24
Continue on US 45
2.0 mi·2 min·US 45
25
Continue on US 45
1.9 mi·2 min·US 45
26
Continue on US 45
1.8 mi·2 min·US 45
27
Continue on US 45
0.8 mi·55 sec·US 45
28
Continue on US 45
2.2 mi·2 min·US 45
29
Continue on US 45
0.8 mi·52 sec·US 45
30
Continue on US 45
0.3 mi·17 sec·US 45
31
Take the exit
0.3 mi·50 sec
Toward MS 25 North, MS 8 East: Amory
32
Continue on MS 8; MS 25
6.5 mi·9 min·MS 8; MS 25
33
Turn left onto Highway 125
5.2 mi·9 min·Highway 125
34
Turn right onto US 278
0.4 mi·59 sec·US 278
35
Turn left onto MS 25
1.1 mi·2 min·South Main Street
Use the left lane.
36
Turn left onto MS 6
2.5 mi·4 min·State Highway 6
37
Turn right onto MS 371
10 mi·17 min·State Highway 371
38
Turn right onto Dorsey Evergreen Road
4.3 mi·16 min·Dorsey Evergreen Road
39
Turn sharp left onto Greenwood Hopewell Road
145 ft·6 sec·Greenwood Hopewell Road
40
Arrive at destination
Greenwood Hopewell Road
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 154.7 miles from Biloxi, MS, or about 2h 58m into the drive.
The longest continuous stretch on this route runs about 106.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 68 miles or 1h 23m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 154.7 miles or 2h 58m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 52m
Traffic, exits, and arrival timing usually matter more near Greenwood, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 309.3 miles and 6h 25m.
Your first comfortable stop window is around 68 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 45 for about 106.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 154.7 mi from Biloxi, MS
· 2h 58m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
13 mi from route
~33 min detour
Free
near mile 309.3
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
14 mi from route
~34 min detour
Free
near mile 309.3
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$46.71 one way
$93.42 round trip
$3.84/gal25.4 MPG avg108 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$51.28
$102.56
premium
$4.56
$55.52
$111.03
diesel
$5.61
$68.29
$136.58
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$47
Meals
$25–$50
Total
$72–$97
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 108.2 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
9 DC fast chargers
· Coverage: good
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Eaton Charging Station
Ocean Springs, Mississippi
Other
1 DCFC
ChargePoint Charging Station
D'Iberville, Mississippi
ChargePoint
1 DCFC
Tesla Destination: 4
Other: 3
ChargePoint: 2
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $32 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
92.8
1
$32.48
$14.85
Efficient EV
77.3
0
$27.06
$12.37
EV Truck/SUV
123.7
1
$43.30
$19.80
Gas CO2
108 kg
EV CO2
36 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Biloxi, MS
Evening
in Biloxi on Thursday
Local time
8:30 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Greenwood, MS
Evening
in Greenwood on Thursday
Local time
8:30 PM
CDT
Current temp
77°F
Unavailable
Live forecast
79°F
Meridian, MS
155 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 25m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Biloxi, MS to Greenwood, MS covers 309.3 miles and takes about 6h 25m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 45, Lance Corporal Roy M Wheat Memorial Highway, US 49. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 154.7 miles from Biloxi, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $46.71 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 23 significant decision points across 309.3 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Biloxi, MS and Greenwood, MS, road signs point toward Jackson, Laurel, Tuscaloosa and Aberdeen.
