Origin
Cape Girardeau, MO
Morning in Cape Girardeau on Monday
Local time
9:42 AM
CDT
Current temp
74°F
Unavailable
Live forecast
Trip from Cape Girardeau, MO to Independence, MO
Drive Time
5h 19m
Distance
341.3 mi
549 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$52
one way
EV Charging
Loading...
station data
Best Time to Leave
4 AM
5h 6m
★
6 AM
5h 19m
8 AM
5h 46m
10 AM
5h 29m
12 PM
5h 26m
3 PM
5h 30m
5 PM
5h 45m
8 PM
5h 11m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Cape Girardeau, MO
Craig Picariello
Independence, MO
Ever Rayan
Trip Overview
The drive from Cape Girardeau, MO to Independence, MO covers 341.3 miles and takes about 5h 19m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on North Kingshighway, I 55 North, Rosa Parks Highway for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $51.84 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
170.6 miles from Cape Girardeau, MO
A natural place for your longest stop of the day , about 2h 39m into the drive .
Drive Character
Expect a 5h 19m drive with frequent turns across 341.3 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 28 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
North Kingshighway is one of the defining roads on this drive.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way.
Route Complexity
3/10
Easy - simple navigation with a manageable amount of wheel time
This is a straightforward 5h 19m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
This route does not have any notably tricky sections. Most of the drive from Cape Girardeau, MO to Independence, MO is straightforward, with well-signed roads and simple exits.
Main Roads
| Road | Distance | Duration |
|---|---|---|
| North Kingshighway | Unavailable | Refreshing |
| I 55 North | Unavailable | Refreshing |
| Rosa Parks Highway | Unavailable | Refreshing |
| I 270 West | Unavailable | Refreshing |
| I 64 | Unavailable | Refreshing |
| I 64 West | Unavailable | Refreshing |
| Avenue of the Saints | Unavailable | Refreshing |
| I 70 West | Unavailable | Refreshing |
Per-road distance and duration are being refreshed from OSRM for this route.
Longest stretch:
North Kingshighway
— detailed segment metrics are refreshing.
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau, MO and Independence, MO.
1
Start on Broadway Street
2.0 mi
·
3 min
·
Broadway Street
2
Turn right onto North Kingshighway
3.6 mi
·
5 min
·
North Kingshighway
3
Take the ramp slight right toward I 55 North: Saint Louis
0.3 mi
·
39 sec
·
I 55 North: Saint Louis
4
Merge slight left
95 mi
·
1 hr 42 min
5
Continue on Rosa Parks Highway
1.3 mi
·
1 min
·
Rosa Parks Highway
6
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
0.2 mi
·
27 sec
·
I 270 West, I 255 East: Kansas City, Chicago
7
Keep slight left to continue on I 270 West: Kansas City
387 ft
·
8 sec
·
I 270 West: Kansas City
8
Continue on I 270 West
0.7 mi
·
1 min
·
I 270 West
9
Merge slight left
11 mi
·
14 min
10
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
0.1 mi
·
17 sec
·
I 64, US 40, US 61: Wentzville, Saint Louis
11
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
0.4 mi
·
49 sec
·
I 64 West, US 40 West, US 61 North: Wentzville
12
Continue on I 64 West, US 40 West, US 61 North: Wentzville
0.1 mi
·
10 sec
·
I 64 West, US 40 West, US 61 North: Wentzville
13
Merge slight left onto Avenue of the Saints
25 mi
·
30 min
·
Avenue of the Saints
14
Take the exit slight left toward I 70 West, US 40 West: Kansas City
0.6 mi
·
1 min
·
I 70 West, US 40 West: Kansas City
15
Merge slight left onto Dwight D Eisenhower Highway
81 mi
·
1 hr 35 min
·
Dwight D Eisenhower Highway
16
Continue on Sheriff Roger I. Wilson Memorial Highway
2.0 mi
·
2 min
·
Sheriff Roger I. Wilson Memorial Highway
17
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
·
1 min
·
Highway Patrol Sgt. Benjamin Booth Memorial Highway
18
Continue on Dwight D. Eisenhower Highway
1.8 mi
·
2 min
·
Dwight D. Eisenhower Highway
19
Continue on U.S. Submarine Veterans' Memorial Highway
54 mi
·
58 min
·
U.S. Submarine Veterans' Memorial Highway
20
Continue on Dwight D. Eisenhower Highway
52 mi
·
56 min
·
Dwight D. Eisenhower Highway
21
Continue on Truman/Eisenhower Presidential Highway
2.7 mi
·
3 min
·
Truman/Eisenhower Presidential Highway
22
Continue on Clifton J. Scott Memorial Highway
1.4 mi
·
1 min
·
Clifton J. Scott Memorial Highway
23
Take the exit slight right toward Noland Road
0.2 mi
·
24 sec
·
Noland Road
24
Turn right onto South Noland Road
3.0 mi
·
5 min
·
South Noland Road
25
Turn left onto East Walnut Street
466 ft
·
23 sec
·
East Walnut Street
26
Turn right onto South Lynn Street
394 ft
·
23 sec
·
South Lynn Street
27
Turn left onto East Kansas Avenue
144 ft
·
6 sec
·
East Kansas Avenue
28
Arrive at your destination
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 170.6 miles from Cape Girardeau, MO, or about 2h 39m into the drive.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 14m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 170.6 miles or 2h 39m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 23m
Traffic, exits, and arrival timing usually matter more near Independence, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Cape Girardeau, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Cape Girardeau, MO
This is one driving day of about 341.3 miles and 5h 19m.
Your first comfortable stop window is around 80 miles from Cape Girardeau, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 170.6 mi from Cape Girardeau, MO · 2h 39m into the drive
Mid-route town
Meal stop
171 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 80 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 170.6 miles from Cape Girardeau, MO, which is a good place for a longer meal and fuel stop.
Arriving in Independence, MO
The final approach into Independence, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Independence, MO.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$51.84 one way
$103.68 round trip
$3.86/gal
25.4 MPG avg
119 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.25 | $57.15 | $114.30 |
| premium | $4.80 | $64.43 | $128.86 |
| diesel | $5.64 | $75.83 | $151.65 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$52
Meals
$25–$50
Total
$77–$102
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 119.4 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $36 in charging · 1 stop · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 102.4 | 1 | $35.84 | $16.38 |
| Efficient EV | 85.3 | 0 | $29.86 | $13.65 |
| EV Truck/SUV | 136.5 | 1 | $47.78 | $21.84 |
Gas CO2
119 kg
EV CO2
40 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Independence, MO
Morning in Independence on Monday
Local time
9:42 AM
CDT
Current temp
49°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
25 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 19m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Cape Girardeau, MO to Independence, MO covers 341.3 miles and takes about 5h 19m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are North Kingshighway, I 55 North, Rosa Parks Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 170.6 miles from Cape Girardeau, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $51.84 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a straightforward 5h 19m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
This route does not have any notably tricky sections. Most of the drive from Cape Girardeau, MO to Independence, MO is straightforward, with well-signed roads and simple exits.
The route from Cape Girardeau, MO to Independence, MO does not surface many named destination signs beyond the main corridor.
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Return Trip
Independence, MO to Cape Girardeau, MOPlan the drive back the other way.
341.4 mi
5h 19m
Continue From Independence, MO
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