Origin
Independence, MO
Late night in Independence on Friday
Local time
5:21 AM
CDT
Current temp
73°F
Unavailable
Live forecast
Trip from Independence, MO to Cape Girardeau, MO
Compiled and reviewed by the Trip.ovh planning team at COD Solutions Oy · Last reviewed Apr 17, 2026 · Editorial standards
Drive Time
6h 30m
Distance
341.6 mi
550 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$53
one way
EV Charging
Unknown
Best Time to Leave
4 AM
6h 18m
★
6 AM
6h 31m
8 AM
6h 55m
10 AM
6h 39m
12 PM
6h 37m
3 PM
6h 40m
5 PM
6h 54m
8 PM
6h 23m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Independence, MO
Wikimedia Commons
Cape Girardeau, MO
Wikimedia Commons
Trip Overview
The drive from Independence, MO to Cape Girardeau, MO covers 341.6 miles and takes about 6h 30m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Dwight D. Eisenhower Highway, Police Officer Steven Jarvis Memorial Highway, U.S. Submarine Veterans' Memorial Highway for much of the mileage, and the overall profile is turn-heavy local drive. The longest uninterrupted segment is about 135.3 miles on Dwight D. Eisenhower Highway. At current regular gas prices, budget about $53.41 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
170.8 miles from Independence, MO
A natural place for your longest stop of the day , about 3h 12m into the drive .
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 30m. Total distance: 341.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 30m drive, plan rest stops for pacing.
Scenic Drive
Turn-heavy local drive route profile.
Drive Character
Expect a 6h 30m drive with frequent turns across 341.6 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 29 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D. Eisenhower Highway is the longest continuous segment at about 135.3 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 3.3 miles in.
Driving Effort
10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 341.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 3.3 miles: Multiple destination signs - pick the right one; at 226.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 226.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Critical Maneuvers
5 of 17 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
6
3.3 mi into trip
|
~6m in
Turn left toward I 70 East: Columbia, Saint Louis
Multiple destination signs - pick the right one
Toward I 70 East: Columbia, Saint Louis
8
226.2 mi into trip
|
~4h 19m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
7
226.5 mi into trip
|
~4h 19m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
238.3 mi into trip
|
~4h 34m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
8
335.7 mi into trip
|
~6h 20m in
Keep slight left at fork toward I 55 Business, US 61 South, MO 34 East: Cape Girardeau
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 99
Toward I 55 Business, US 61 South, MO 34 East:...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Independence, MO to Cape Girardeau, MO, road signs begin pointing toward Memphis along the way.
Memphis
226.2 mi in
|
~4h 19m
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Dwight D. Eisenhower Highway | 135.3 mi | 2h 34m |
| Police Officer Steven Jarvis Memorial Highway | 93.1 mi | 1h 39m |
| U.S. Submarine Veterans' Memorial Highway | 54.4 mi | 58m |
| Avenue of the Saints | 25.1 mi | 30m |
| I 270 | 11.5 mi | 14m |
| North Kingshighway | 3.6 mi | 6m |
| South Noland Road | 3.1 mi | 5m |
| Truman/Eisenhower Presidential Highway | 2.6 mi | 3m |
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Turn-by-Turn Driving Directions
Step-by-step road directions between Independence, MO and Cape Girardeau, MO.
1
Start on East Kansas Avenue
145 ft
·
8 sec
·
East Kansas Avenue
2
Turn right onto South Lynn Street
394 ft
·
22 sec
·
South Lynn Street
3
Turn left onto East Walnut Street
466 ft
·
25 sec
·
East Walnut Street
4
Turn right onto South Noland Road
3.1 mi
·
5 min
·
South Noland Road
5
Turn left
0.2 mi
·
26 sec
Toward I 70 East: Columbia, Saint Louis
6
Merge onto I 70
1.5 mi
·
1 min
·
Clifton J. Scott Memorial Highway
7
Continue on I 70
2.6 mi
·
3 min
·
Truman/Eisenhower Presidential Highway
8
Continue on I 70
53 mi
·
56 min
·
Dwight D. Eisenhower Highway
9
Continue on I 70; US 40
32 mi
·
34 min
·
U.S. Submarine Veterans' Memorial Highway
10
Keep slight left at fork onto I 70
22 mi
·
24 min
·
U.S. Submarine Veterans' Memorial Highway
11
Continue on I 70; US 40
1.8 mi
·
2 min
·
Dwight D. Eisenhower Highway
12
Continue on I 70; US 40
1.6 mi
·
1 min
·
Highway Patrol Sgt. Benjamin Booth Memorial Highway
13
Continue on I 70; US 40
1.9 mi
·
2 min
·
Sheriff Roger I. Wilson Memorial Highway
14
Continue on I 70; US 40
81 mi
·
1 hr 35 min
·
Dwight D. Eisenhower Highway
15
Take the exit onto US 40
0.3 mi
·
33 sec
·
US 40
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Chesterfield
16
Merge onto I 64; US 40; US 61
25 mi
·
30 min
·
Avenue of the Saints
Use the straight / slight left lanes.
17
Take the exit
0.3 mi
·
38 sec
Exit 25
Toward I 270: Chicago, Memphis
Use the slight right lane.
18
Keep slight right at fork
0.3 mi
·
31 sec
Toward I 270 South: Memphis
Use the slight right lane.
19
Merge onto I 270
11 mi
·
14 min
·
I 270
Use the straight lane.
20
Take the exit
0.4 mi
·
27 sec
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Use the straight / slight right lanes.
21
Keep slight right at fork
0.4 mi
·
43 sec
Toward I 55 South: Memphis
22
Merge onto I 55
1.5 mi
·
1 min
·
Rosa Parks Highway
23
Continue on I 55
1.8 mi
·
2 min
·
Officer Thomas G. Smith, Jr. Memorial Highway
24
Continue on I 55
93 mi
·
1 hr 39 min
·
Police Officer Steven Jarvis Memorial Highway
Use the straight / slight right lanes.
25
Take the exit
0.2 mi
·
17 sec
Exit 99
Toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
26
Keep slight left at fork
0.3 mi
·
28 sec
Exit 99
Toward I 55 Business, US 61 South, MO 34 East: Cape Girardeau
27
Continue on I 55 Bus; US 61; MO 34
3.6 mi
·
6 min
·
North Kingshighway
28
Turn left onto Broadway Street
2.0 mi
·
3 min
·
Broadway Street
29
Arrive at destination
Broadway Street
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 170.8 miles from Independence, MO, or about 3h 12m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 75 miles or 1h 23m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 170.8 miles or 3h 12m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 22m
Traffic, exits, and arrival timing usually matter more near Cape Girardeau, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Independence, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Independence, MO
This is one driving day of about 341.6 miles and 6h 30m.
Your first comfortable stop window is around 75 miles from Independence, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 170.8 mi from Independence, MO · 3h 12m into the drive
Mid-route town
Meal stop
171 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 75 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 170.8 miles from Independence, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Dwight D. Eisenhower Highway if your tank is already low. That segment runs about 135.3 miles.
Arriving in Cape Girardeau, MO
The final approach into Cape Girardeau, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Cape Girardeau, MO.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$53.41 one way
$106.81 round trip
$3.97/gal
25.4 MPG avg
120 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $58.64 | $117.27 |
| premium | $4.89 | $65.74 | $131.48 |
| diesel | $5.61 | $75.42 | $150.84 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$53
Meals
$25–$50
Total
$78–$103
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 119.5 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $36 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 102.5 | 1 | $35.87 | $16.40 |
| Efficient EV | 85.4 | 0 | $29.89 | $13.66 |
| EV Truck/SUV | 136.6 | 1 | $47.82 | $21.86 |
Gas CO2
120 kg
EV CO2
40 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Cape Girardeau, MO
Late night in Cape Girardeau on Friday
Local time
5:21 AM
CDT
Current temp
81°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
8 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 30m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Independence, MO to Cape Girardeau, MO covers 341.6 miles and takes about 6h 30m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D. Eisenhower Highway, Police Officer Steven Jarvis Memorial Highway, U.S. Submarine Veterans' Memorial Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 170.8 miles from Independence, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $53.41 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 17 significant decision points across 341.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 3.3 miles: Multiple destination signs - pick the right one; at 226.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 226.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
On the drive from Independence, MO to Cape Girardeau, MO, road signs begin pointing toward Memphis along the way.
How this page is built
Compiled and maintained by the Trip.ovh planning team at COD Solutions Oy (Helsinki). Each route is built from authoritative open government and mapping datasets rather than crowdsourced reviews. Distances and geometry come from OSRM over OpenStreetMap. Fuel cost uses EIA weekly regional averages. Pages are published only after passing our data-quality checks; our methodology page documents refresh cadence, editorial standards, and known limitations.
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