The drive from Farmington, MS to Biloxi, MS covers 360.4 miles and takes about 7h 6m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 59, US 45, US Highway 45 Aiternate for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 88.7 miles on I 59.
At current regular gas prices, budget about $54.43 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
180.2 miles from Farmington, MS
A natural place for your longest stop of the day
, about 3h 38m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 7h 6m. Total distance: 360.4 miles.
Family Friendly
Moderate complexity with 2 natural rest stops along the way.
Solo Traveler
7h 6m drive, plan rest stops for pacing.
Drive Character
This is a 7h 6m highway drive covering 360.4 miles, with most of the trip on I 59 and US 45. The longest continuous stretch is about 88.7 miles on I 59.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 34 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 59 is the longest continuous segment at about 88.7 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 59 and US 45. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 200.3 miles in near I 59.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 16 significant decision points across 360.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 200.3 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 289 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 292.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 16 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
8
200.3 mi into trip|~4h 2m in|I 59
Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 59 South: Laurel, New Orleans
7
289 mi into trip|~5h 38m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
292.2 mi into trip|~5h 42m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
292.5 mi into trip|~5h 43m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
6
292.6 mi into trip|~5h 43m in|US 49
Turn right onto US 49
Lane positioning matters here
Use the straight lane.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Farmington, MS and Biloxi, MS, road signs point toward New Orleans, Mobile, Gulfport, Mississippi Gulf Coast, Multi Purpose Center and Hattiesburg.
New Orleans
200.3 mi in|~4h 2m|via I 59
Mobile
289 mi in|~5h 38m|via US 98
Gulfport
292.2 mi in|~5h 42m
Mississippi Gulf Coast
292.2 mi in|~5h 42m
Multi Purpose Center
292.5 mi in|~5h 43m
Hattiesburg
292.5 mi in|~5h 43m
Main Roads
Road
Distance
Duration
I 59
88.7 mi
1h 36m
US 45
62.1 mi
1h 12m
US Highway 45 Aiternate
60.6 mi
1h 9m
US Highway 45 Alternate
54.7 mi
1h 6m
US 49
41.9 mi
49m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
I 20
8.1 mi
9m
US 45 ALT
7.2 mi
8m
Longest stretch:
I 59
— 88.7 mi, about 1h 36m
Turn-by-Turn Driving Directions
Step-by-step road directions between Farmington, MS and Biloxi, MS.
1
Start on County Road 217
146 ft·11 sec·County Road 217
2
Turn left onto County Road 200
1.0 mi·2 min·County Road 200
3
Continue on Proper Street
2.6 mi·6 min·Proper Street
4
Continue on Cruise Street
0.3 mi·43 sec·Cruise Street
Use the straight / right lanes.
5
Turn left onto North Fillmore Street
0.1 mi·17 sec·North Fillmore Street
6
Turn right onto South Tate Street
3.0 mi·5 min·South Tate Street
Use the straight / right lanes.
7
Turn left onto US 45
1.9 mi·2 min·US 45
Use the straight / right lanes.
8
Continue on US 45
0.5 mi·31 sec·US 45
9
Continue on US 45
12 mi·14 min·US 45
Use the straight / right lanes.
10
Continue on US 45
43 mi·51 min·US 45
Use the straight / right lanes.
11
Continue on US 45 ALT
1.4 mi·1 min·US 45 ALT
12
Continue on US 45 ALT
2.2 mi·2 min·US 45 ALT
13
Continue on US 45 ALT
1.5 mi·1 min·US 45 ALT
14
Continue on US 45 ALT
0.7 mi·49 sec·US 45 ALT
15
Continue on US 45 ALT
1.4 mi·1 min·US 45 ALT
16
Continue on US 45 ALT
55 mi·1 hr 6 min·US Highway 45 Alternate
Use the straight lane.
17
Continue on US 45
61 mi·1 hr 9 min·US Highway 45 Aiternate
18
Keep slight right at fork onto US 45
3.9 mi·4 min·US 45
19
Take the exit
0.5 mi·1 min
Toward I 59 South, I 20 West: Meridian
20
Merge onto I 20; I 59
6.3 mi·7 min·I 20; I 59
Use the straight / slight right lanes.
21
Continue on I 20; I 59; US 80
1.8 mi·2 min·I 20; I 59; US 80
Use the straight lane.
22
Keep slight left at fork onto I 59
89 mi·1 hr 36 min·I 59
Toward I 59 South: Laurel, New OrleansUse the slight left / slight right lanes.
23
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
24
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
25
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
26
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
27
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
28
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
29
Continue on I 110
3.2 mi·4 min·I 110
30
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
31
Turn left onto Division Street
0.6 mi·1 min·Division Street
32
Turn right onto Main Street
0.5 mi·1 min·Main Street
33
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
34
Arrive at destination
Howard Avenue
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 180.2 miles from Farmington, MS, or about 3h 38m into the drive.
The longest continuous stretch on this route runs about 88.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 79 miles or 1h 39m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 180.2 miles or 3h 38m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 52m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Farmington, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
Day 1
Settle into the route from Farmington, MS
This is one driving day of about 360.4 miles and 7h 6m.
Your first comfortable stop window is around 79 miles from Farmington, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on I 59 for about 88.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 180.2 mi from Farmington, MS
· 3h 38m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Natchez Trace National Scenic Trail
National Scenic Trail
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
1 mi from route
~4 min detour
Free
near mile 49.7
Park Closure: Partial Closure of Rocky Springs Trail
Park Closure: Temporary Blackland Prairie Trail Closure to Equestrians
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
4 mi from route
~11 min detour
Free
near mile 49.7
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $38 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
108.1
1
$37.84
$17.30
Efficient EV
90.1
1
$31.53
$14.42
EV Truck/SUV
144.2
1
$50.46
$23.07
Gas CO2
126 kg
EV CO2
42 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Farmington, MS
Morning
in Farmington on Friday
Local time
11:40 AM
CDT
Current temp
53°F
Unavailable
Live forecast
Destination
Biloxi, MS
Morning
in Biloxi on Friday
Local time
11:40 AM
CDT
Current temp
61°F
Unavailable
Live forecast
79°F
Meridian, MS
180 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
8 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
7h 6m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Farmington, MS to Biloxi, MS covers 360.4 miles and takes about 7h 6m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 59, US 45, US Highway 45 Aiternate. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 180.2 miles from Farmington, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $54.43 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 2 meaningful breaks for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 16 significant decision points across 360.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 200.3 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 289 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 292.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Farmington, MS and Biloxi, MS, road signs point toward New Orleans, Mobile, Gulfport, Mississippi Gulf Coast, Multi Purpose Center and Hattiesburg.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
