Trip from Fredericktown, MO to East Independence, MO

Drive Time

6h 6m

Distance

313.2 mi

504 km

Drive Score

9/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$48

one way

EV Charging

Loading...

station data

Best Time to Leave

Save up to 39 min
4 AM
5h 53m ★
6 AM
6h 6m
8 AM
6h 32m
10 AM
6h 15m
12 PM
6h 13m
3 PM
6h 16m
5 PM
6h 31m
8 PM
5h 58m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Downtown East Independence, MO, MO

East Independence, MO

Momo King

Trip Overview

The drive from Fredericktown, MO to East Independence, MO covers 313.2 miles and takes about 6h 6m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on Dwight D Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Dwight D. Eisenhower Highway for much of the mileage, and the overall profile is turn-heavy local drive. The longest uninterrupted segment is about 80.7 miles on Dwight D Eisenhower Highway. At current regular gas prices, budget about $47.57 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

156.6 miles from Fredericktown, MO

A natural place for your longest stop of the day , about 3h 7m into the drive .

Drive Character

Expect a 6h 6m drive with frequent turns across 313.2 miles of local and secondary roads.

This route has more turning and local-road decision points than a simple highway run.
There are about 35 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D Eisenhower Highway is the longest continuous segment at about 80.7 miles.

How Hard Is This Drive?

Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 76 miles in.

Route Complexity 10/10

High effort - long or complex enough to need steady focus all day

This is a demanding drive. With 23 significant decision points across 313.2 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 76 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 76.2 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 88.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.

Critical Maneuvers

5 of 23 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

8
76 mi into trip | ~1h 28m in

Take the exit toward I 270 West, I 255 East: Kansas City, Chicago

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 196 Toward I 270 West, I 255 East: Kansas City, Chi...
8
76.2 mi into trip | ~1h 29m in

Keep slight left at fork toward I 270 West: Kansas City

Highway fork - watch signs carefully. Lane positioning matters here

Use the slight left lane. Toward I 270 West: Kansas City
8
88.5 mi into trip | ~1h 44m in

Take the exit toward I 64, US 40, US 61: Wentzville, Saint Louis

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 12 Toward I 64, US 40, US 61: Wentzville, Saint Lo...
8
88.6 mi into trip | ~1h 45m in

Keep slight left at fork toward I 64 West, US 40 West, US 61 North: Wentzville

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left lane. Toward I 64 West, US 40 West, US 61 North: Went...
8
114.6 mi into trip | ~2h 17m in | US 40

Take the exit onto US 40 toward I 70 West, US 40 West: Kansas City

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the straight / slight left lanes. Exit 1A Toward I 70 West, US 40 West: Kansas City

Towns Along This Route

Between Fredericktown, MO and East Independence, MO, road signs point toward Chicago and Saint Louis.

Chicago

76 mi in | ~1h 28m

Saint Louis

88.5 mi in | ~1h 44m

Main Roads

Road Distance Duration
Dwight D Eisenhower Highway 80.7 mi 1h 35m
U.S. Submarine Veterans' Memorial Highway 54.4 mi 58m
Dwight D. Eisenhower Highway 54.3 mi 58m
US 67 51.9 mi 59m
Avenue of the Saints 25.4 mi 30m
I 55 20.5 mi 22m
I 270 11.5 mi 14m
Sheriff Roger I. Wilson Memorial Highway 2 mi 2m
Longest stretch: Dwight D Eisenhower Highway — 80.7 mi, about 1h 35m

Turn-by-Turn Driving Directions

Step-by-step road directions between Fredericktown, MO and East Independence, MO.

1

Start on East Main Street

44 ft · 2 sec · East Main Street
2

Enter roundabout onto West Main Street

270 ft · 8 sec · West Main Street
3

Continue on West Main Street

1.2 mi · 2 min · West Main Street
4

Enter roundabout onto US 67 Business; MO 72

155 ft · 2 sec · US 67 Business; MO 72
5

Continue on US 67 Business; MO 72

0.3 mi · 38 sec · US 67 Business; MO 72
6

Take the ramp

0.3 mi · 32 sec
Toward US 67 North: Farmington
7

Merge onto US 67

52 mi · 59 min · US 67
8

Keep slight right at fork onto US 67

0.3 mi · 27 sec · US 67
9

Take the exit

0.3 mi · 49 sec
Toward I 55 North: Saint Louis
10

Merge onto I 55

21 mi · 22 min · I 55
11

Continue on I 55

1.3 mi · 1 min · Rosa Parks Highway
12

Take the exit

0.2 mi · 27 sec
Exit 196 Toward I 270 West, I 255 East: Kansas City, Chicago Use the slight right lane.
13

Keep slight left at fork

388 ft · 8 sec
Toward I 270 West: Kansas City Use the slight left lane.
14

Continue on this road

0.7 mi · 1 min · this road
Exit 196 Toward I 270 West
15

Merge onto I 270

11 mi · 14 min · I 270
Use the straight lane.
16

Take the exit

0.1 mi · 17 sec
Exit 12 Toward I 64, US 40, US 61: Wentzville, Saint Louis Use the slight right lane.
17

Keep slight left at fork

0.4 mi · 48 sec
Toward I 64 West, US 40 West, US 61 North: Wentzville Use the slight left lane.
18

Continue on this road

0.1 mi · 9 sec · this road
Exit 12 Toward I 64 West, US 40 West, US 61 North: Wentzville
19

Merge onto I 64; US 40; US 61

25 mi · 30 min · Avenue of the Saints
Use the straight lane.
20

Take the exit onto US 40

0.6 mi · 1 min · US 40
Exit 1A Toward I 70 West, US 40 West: Kansas City Use the straight / slight left lanes.
21

Merge onto I 70; US 40

81 mi · 1 hr 35 min · Dwight D Eisenhower Highway
22

Continue on I 70; US 40

2.0 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
23

Continue on I 70; US 40

1.6 mi · 1 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
24

Continue on I 70; US 40

1.8 mi · 2 min · Dwight D. Eisenhower Highway
25

Continue on I 70; US 40

54 mi · 58 min · U.S. Submarine Veterans' Memorial Highway
26

Continue on I 70; US 40

52 mi · 56 min · Dwight D. Eisenhower Highway
27

Take the exit

0.3 mi · 40 sec
Exit 17 Toward Little Blue Parkway, 39th Street, Mall Entrance Use the slight right lane.
28

Turn right onto South Little Blue Parkway

1.6 mi · 3 min · South Little Blue Parkway
29

Turn left onto East R.D. Mize Road

0.2 mi · 37 sec · East R.D. Mize Road
30

Turn right onto South Jackson Drive

1.2 mi · 2 min · South Jackson Drive
31

Turn straight onto Holke Road

0.9 mi · 2 min · Holke Road
32

Turn left onto East Truman Road

0.7 mi · 1 min · East Truman Road
33

Turn right onto Main Road

0.3 mi · 1 min · Main Road
34

Turn right onto East 9th Street South

79 ft · 3 sec · East 9th Street South
35

Arrive at destination

East 9th Street South

Trip Plan

Morning Departure

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Evening Departure

This is a long drive — plan for a morning departure or consider splitting it into two days.

You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 156.6 miles from Fredericktown, MO, or about 3h 7m into the drive.
The longest continuous stretch on this route runs about 80.7 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 34m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 156.6 miles or 3h 7m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 4h 59m

Traffic, exits, and arrival timing usually matter more near East Independence, MO than in the middle of the route.

Before You Leave

+

Open the route before leaving Fredericktown, MO so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Fredericktown, MO

This is one driving day of about 313.2 miles and 6h 6m.

Your first comfortable stop window is around 80 miles from Fredericktown, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D Eisenhower Highway for about 80.7 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 156.6 mi from Fredericktown, MO · 3h 7m into the drive

Downtown Alton, IL, IL

Mid-route town

Meal stop

Alton, IL

157 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Cahokia, IL

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Quincy, IL

Meal break

The midpoint is around 156.6 miles from Fredericktown, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before Dwight D Eisenhower Highway if your tank is already low. That segment runs about 80.7 miles.

Arriving in East Independence, MO

The final approach into East Independence, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around East Independence, MO.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$47.57 one way

$95.14 round trip

$3.86/gal 25.4 MPG avg 110 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.25 $52.44 $104.89
premium $4.80 $59.13 $118.25
diesel $5.64 $69.58 $139.16

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$48

Meals

$25–$50

Total

$73–$98

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 109.6 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $33 in charging · 1 stop · 66% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 94 1 $32.89 $15.03
Efficient EV 78.3 0 $27.40 $12.53
EV Truck/SUV 125.3 1 $43.85 $20.04

Gas CO2

110 kg

EV CO2

37 kg (66% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 3 days ago

Origin

Fredericktown, MO

Morning in Fredericktown on Monday

Local time

10:51 AM

CDT

Current temp

79°F

Unavailable

Live forecast

Destination

East Independence, MO

Morning in East Independence on Monday

Local time

10:51 AM

CDT

Current temp

49°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

30 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

6h 6m on the road

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Fredericktown, MO to East Independence, MO covers 313.2 miles and takes about 6h 6m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Dwight D. Eisenhower Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 156.6 miles from Fredericktown, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $47.57 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 23 significant decision points across 313.2 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 76 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 76.2 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 88.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Fredericktown, MO and East Independence, MO, road signs point toward Chicago and Saint Louis.

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Return Trip

East Independence, MO to Fredericktown, MO

Plan the drive back the other way.

312.3 mi 6h 4m

Explore more options from Fredericktown, MO or browse trips ending in East Independence, MO.

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