The drive from Grenada, MS to Biloxi, MS covers 276.6 miles and takes about 5h 24m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 55, Highway 49 South, US 49 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 111 miles on I 55.
At current regular gas prices, budget about $41.77 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
138.3 miles from Grenada, MS
A natural place for your longest stop of the day
, about 2h 35m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 24m. Total distance: 276.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 24m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (95%). Some complex stretches to watch for.
Drive Character
This is a 5h 24m highway drive covering 276.6 miles, with most of the trip on I 55 and Highway 49 South. The longest continuous stretch is about 111 miles on I 55.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 22 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 55 is the longest continuous segment at about 111 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 55 and Highway 49 South. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 114.6 miles in near US 49.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 15 significant decision points across 276.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 114.6 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 197.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 205.2 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 15 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
114.6 mi into trip|~2h 6m in|US 49
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Richland, Hattiesburg
7
197.1 mi into trip|~3h 47m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
205.2 mi into trip|~3h 56m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
208.4 mi into trip|~4h in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
208.7 mi into trip|~4h 1m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Grenada, MS and Biloxi, MS, road signs point toward Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast, Mobile and Gulfport - among others.
Hattiesburg
113.7 mi in|~2h 5m
Richland
114.6 mi in|~2h 6m|via US 49
Gulf Coast
197.1 mi in|~3h 47m
Mississippi Gulf Coast
197.5 mi in|~3h 48m|via I 59
Mobile
205.2 mi in|~3h 56m|via US 98
Gulfport
208.4 mi in|~4h
Multi Purpose Center
208.7 mi in|~4h 1m
Main Roads
Road
Distance
Duration
I 55
111 mi
2h
Highway 49 South
80.3 mi
1h 37m
US 49
44.1 mi
53m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
Sunset Drive
2.4 mi
3m
Longest stretch:
I 55
— 111 mi, about 2h
Turn-by-Turn Driving Directions
Step-by-step road directions between Grenada, MS and Biloxi, MS.
1
Start on MS 8; MS 333 Scenic
2.4 mi·3 min·Sunset Drive
2
Turn left
0.3 mi·34 sec
3
Merge onto I 55
111 mi·2 hr·I 55
4
Take the exit
0.9 mi·1 min
Toward I 20 East, US 49 South: Meridian, Hattiesburg
5
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
6
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
7
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
8
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
9
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
10
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
11
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
12
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
13
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
14
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
15
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
16
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
17
Continue on I 110
3.2 mi·4 min·I 110
18
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
19
Turn left onto Division Street
0.6 mi·1 min·Division Street
20
Turn right onto Main Street
0.5 mi·1 min·Main Street
21
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
22
Arrive at destination
Howard Avenue
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 138.3 miles from Grenada, MS, or about 2h 35m into the drive.
The longest continuous stretch on this route runs about 111 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 61 miles or 1h 7m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 138.3 miles or 2h 35m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 23m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Grenada, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Grenada, MS
This is one driving day of about 276.6 miles and 5h 24m.
Your first comfortable stop window is around 61 miles from Grenada, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 55 for about 111 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 138.3 mi from Grenada, MS
· 2h 35m into the drive
The midpoint is around 139 miles from Grenada, MS, which is a good place for a longer meal and fuel stop.
Arriving in Biloxi, MS
The final approach into Biloxi, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Biloxi, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$41.77 one way
$83.55 round trip
$3.84/gal25.4 MPG avg97 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$45.86
$91.71
premium
$4.56
$49.65
$99.29
diesel
$5.61
$61.07
$122.14
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$42
Meals
$25–$50
Total
$67–$92
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 96.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $29 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
83
1
$29.04
$13.28
Efficient EV
69.2
0
$24.20
$11.06
EV Truck/SUV
110.6
1
$38.72
$17.70
Gas CO2
97 kg
EV CO2
32 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Grenada, MS
Morning
in Grenada on Saturday
Local time
9:59 AM
CDT
Current temp
79°F
Unavailable
Live forecast
Destination
Biloxi, MS
Morning
in Biloxi on Saturday
Local time
9:59 AM
CDT
Current temp
61°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
18 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 24m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Grenada, MS to Biloxi, MS covers 276.6 miles and takes about 5h 24m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 55, Highway 49 South, US 49. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 138.3 miles from Grenada, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $41.77 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 15 significant decision points across 276.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 114.6 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 197.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 205.2 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Grenada, MS and Biloxi, MS, road signs point toward Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast, Mobile and Gulfport - among others.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
