Drive Time
3h 31m
Distance
176.4 mi
284 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$27
one way
Photo: Alex Borelli
The drive from Holly Springs, MS to City of Greenville, MS covers 176.4 miles and takes about 3h 31m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 61, I 22, I 269 for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 113.8 miles on US 61. At current regular gas prices, budget about $26.97 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
88.2 miles from Holly Springs, MS
A natural place for your longest stop of the day , about 1h 41m into the drive .
This is a 3h 31m highway drive covering 176.4 miles, with most of the trip on US 61 and I 22. The longest continuous stretch is about 113.8 miles on US 61.
This is a straightforward highway drive that stays mostly on US 61 and I 22. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 19.4 miles in.
Demanding - plan breaks and stay ahead of the key maneuvers
This is a demanding drive. With 16 significant decision points across 176.4 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 19.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 19.9 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 20.3 miles: Lane positioning matters here. Multiple destination signs - pick the right one.
These are the spots where you need to pay the most attention. Preview them before you drive.
Take the exit toward I 269, MS 304: Tunica, Collierville
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Keep slight left at fork toward I 269 South, MS 304 West: Tunica
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Turn slight right toward I 269 South, MS 304 West: Tunica
Lane positioning matters here. Multiple destination signs - pick the right one
Keep slight left at fork toward I 269 South, MS 304 West: Tunica
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Keep slight left at fork toward US 61 South: Tunica
Highway fork - watch signs carefully
On the drive from Holly Springs, MS to City of Greenville, MS, road signs begin pointing toward Collierville along the way.
Collierville
| Road | Distance | Duration |
|---|---|---|
| US 61 | 113.8 mi | 2h 15m |
| I 22 | 17.7 mi | 19m |
| I 269 | 15.3 mi | 16m |
| I 69 | 10.6 mi | 11m |
| MS 182 | 7.8 mi | 11m |
| MS 304 | 2.8 mi | 2m |
| North Broad Street | 1.4 mi | 2m |
| South Craft Street | 1.3 mi | 2m |
Step-by-step road directions between Holly Springs, MS and City of Greenville, MS.
Start on MS 7; MS 178
Turn right onto MS 4; MS 7
Turn left onto MS 4; MS 7
Take the ramp
Merge onto I 22; US 78
Take the exit
Keep slight left at fork
Turn slight right
Keep slight left at fork
Merge onto I 269; MS 304
Continue on I 69; MS 304
Keep slight left at fork onto MS 304
Keep slight left at fork
Merge onto US 61
Turn right onto Griffin Road
Turn left onto Old Hwy 61
Turn straight onto North Broad Street
Turn right onto MS 182
Turn left onto MS 1
Turn right onto East Reed Road
Turn left onto Sandy Avenue
Arrive at destination
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 31m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 88.2 miles or 1h 41m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 49m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Open the route before leaving Holly Springs, MS so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Holly Springs, MS
This is one driving day of about 176.4 miles and 3h 31m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 88.2 mi from Holly Springs, MS · 1h 41m into the drive
Mid-route town
Meal stop
88 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 88.2 miles from Holly Springs, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before US 61 if your tank is already low. That segment runs about 113.8 miles.
The final approach into City of Greenville, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around City of Greenville, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$26.97 one way
$53.93 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.26 | $29.58 | $59.16 |
| premium | $4.61 | $32.02 | $64.03 |
| diesel | $5.64 | $39.19 | $78.38 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$27
Meals
$25–$50
Total
$52–$77
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 61.7 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $19 in charging · 0 stops · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 52.9 | 0 | $18.52 | $8.47 |
| Efficient EV | 44.1 | 0 | $15.43 | $7.06 |
| EV Truck/SUV | 70.6 | 0 | $24.70 | $11.29 |
Gas CO2
62 kg
EV CO2
21 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Late night in Holly Springs on Sunday
Local time
2:32 AM
CDT
Current temp
65°F
Forecast unavailable right now
Destination
Late night in City of Greenville on Sunday
Local time
2:32 AM
CDT
Current temp
68°F
Forecast unavailable right now
Along the Route
64°F
Dermott, AR
88 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
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