Drive Time
4h 54m
Distance
238.9 mi
384 km
Drive Score
9/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$37
one way
Photo: Alex Borelli
Spanning 238.9 miles across Mississippi, this drive from Waynesboro to Greenville takes approximately 4 hours and 54 minutes. You will primarily navigate via US 49, US 49W, and Medgar Evers Boulevard. Given the duration, this route is perfectly manageable as a single-day trip, though you should budget about $37 for fuel to cover the distance. Since both the origin and destination are located within the Southeast region, you will experience a consistent cultural and geographic transition across the state. It is a straightforward trip that avoids the need for an overnight split, making it an efficient choice for those looking to reach the Mississippi Delta from the southeastern corner of the state.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
119.4 miles from Waynesboro, MS
A natural place for your longest stop of the day , about 2h 25m into the drive .
Expect a highway-focused journey, as roughly 69% of your travel time will be spent on major thoroughfares. The road maintains a steady pace, highlighted by a longest uninterrupted stretch of 64.3 miles on US 49. While the route is designed for efficient transit, the shift from southeastern landscapes toward the Delta region provides a noticeable change in the horizon. You will spend most of your time behind the wheel on high-speed roads, requiring a focused driving style rather than a technical one. The experience is practical and functional, prioritizing direct navigation over winding backroads.
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 2.7 miles in near US 84.
Demanding - plan breaks and stay ahead of the key maneuvers
This is a demanding drive. With 21 significant decision points across 238.9 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 2.7 miles (US 84): Lane positioning matters here; at 29.7 miles (Sawmill Road): Highway fork - watch signs carefully; at 29.8 miles (Sawmill Road): Roundabout - know your exit number before entering.
These are the spots where you need to pay the most attention. Preview them before you drive.
At end of road, turn left onto US 84
Lane positioning matters here
Keep slight left at fork onto Sawmill Road
Highway fork - watch signs carefully
Enter roundabout onto Sawmill Road
Roundabout - know your exit number before entering
Take the exit toward US 49 North: Jackson
Exit ramp - move to the correct lane early
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Between Waynesboro, MS and City of Greenville, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Jackson
Yazoo City
Vicksburg
| Road | Distance | Duration |
|---|---|---|
| US 49 | 64.3 mi | 1h 18m |
| US 49W | 46.7 mi | 56m |
| Medgar Evers Boulevard | 39.5 mi | 48m |
| Veterans Memorial Highway | 27.2 mi | 31m |
| US 84 | 26.3 mi | 30m |
| US 82 | 15.8 mi | 19m |
| MS 182 | 8.3 mi | 12m |
| I 20 | 4.3 mi | 5m |
Step-by-step road directions between Waynesboro, MS and City of Greenville, MS.
Start on MS 184
Turn straight onto MS 184
At end of road, turn left onto US 84
At end of road, turn left onto US 11
Continue on US 11
Turn left onto North Magnolia Street
Continue on Sawmill Road
Keep slight left at fork onto Sawmill Road
Enter roundabout onto Sawmill Road
Continue on Sawmill Road
Continue on West 5th Street
Continue on US 84; MS 28
Take the exit
Merge onto US 49
Take the exit onto US 49
Keep slight left at fork onto US 49
Keep slight left at fork onto US 49
Merge onto I 20; I 55; US 49
Keep slight right at fork onto I 20; US 49
Take the exit onto US 49
Take the exit onto US 49
Merge onto US 49
Take the exit onto US 49W
Turn left onto US 82
Keep slight left at fork onto US 82
Keep slight left at fork onto US 82
Turn right onto MS 182
Turn left onto MS 1
Turn right onto East Reed Road
Turn left onto Sandy Avenue
Arrive at destination
To keep your drive smooth, plan for at least one dedicated stop to stretch your legs and refresh during the nearly five-hour trek. Leaving early in the day is your best bet to avoid potential traffic fatigue and ensure you arrive in Greenville with plenty of daylight to spare. Since you are looking at a $37 fuel budget, confirm your vehicle's range before departing Waynesboro to avoid unnecessary detours for gas. Take advantage of the flexibility offered by a one-day trip by keeping your itinerary light, allowing you to adjust your pace based on how you feel on the road. Specifically, keep a close watch on your speed as you transition between the various highway segments along US 49 and US 49W.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 36m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 119.4 miles or 2h 25m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 59m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Open the route before leaving Waynesboro, MS so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Waynesboro, MS
This is one driving day of about 238.9 miles and 4h 54m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 119.4 mi from Waynesboro, MS · 2h 25m into the drive
Mid-route town
Meal stop
119 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 119.4 miles from Waynesboro, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before US 49 if your tank is already low. That segment runs about 64.3 miles.
The final approach into City of Greenville, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around City of Greenville, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$36.52 one way
$73.04 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.26 | $40.06 | $80.12 |
| premium | $4.61 | $43.36 | $86.72 |
| diesel | $5.64 | $53.08 | $106.15 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$37
Meals
$25–$50
Total
$62–$87
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 83.6 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $25 in charging · 0 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 71.7 | 0 | $25.08 | $11.47 |
| Efficient EV | 59.7 | 0 | $20.90 | $9.56 |
| EV Truck/SUV | 95.6 | 1 | $33.45 | $15.29 |
Gas CO2
84 kg
EV CO2
28 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Late night in Waynesboro on Sunday
Local time
2:32 AM
CDT
Current temp
63°F
Forecast unavailable right now
Destination
Late night in City of Greenville on Sunday
Local time
2:32 AM
CDT
Current temp
68°F
Forecast unavailable right now
Along the Route
85°F
Magee, MS
119 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
An early start around 7-8 AM gets you there with plenty of daylight left.
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