The drive from Lee's Summit, MO to Sainte Genevieve, MO covers 293.4 miles and takes about 5h 41m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Police Officer Steven Jarvis Memorial Highway for much of the mileage,
and the overall profile is turn-heavy local drive.
The longest uninterrupted segment is about 135.3 miles on Dwight D. Eisenhower Highway.
At current regular gas prices, budget about $45.87 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
146.7 miles from Lee's Summit, MO
A natural place for your longest stop of the day
, about 2h 45m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 41m. Total distance: 293.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 41m drive, comfortable solo distance.
Scenic Drive
Turn-heavy local drive route profile with national parks nearby.
Drive Character
Expect a 5h 41m drive with frequent turns across 293.4 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 31 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D. Eisenhower Highway is the longest continuous segment at about 135.3 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 9.8 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 293.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 9.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 204.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 229.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 20 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
7
9.8 mi into trip|~14m in
Take the exit toward I 70 East: Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 16B
Toward I 70 East: Saint Louis
6
204.5 mi into trip|~3h 53m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
8
229.9 mi into trip|~4h 24m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
7
230.2 mi into trip|~4h 24m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
242.1 mi into trip|~4h 39m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Lee's Summit, MO to Sainte Genevieve, MO, road signs begin pointing toward Memphis along the way.
Memphis
229.9 mi in|~4h 24m
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Police Officer Steven Jarvis Memorial Highway
38.1 mi
40m
Avenue of the Saints
25.1 mi
30m
I 270
11.5 mi
14m
US 61
7.3 mi
10m
I 470
7 mi
8m
Southeast Douglas Street
2.2 mi
4m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Turn-by-Turn Driving Directions
Step-by-step road directions between Lee's Summit, MO and Sainte Genevieve, MO.
1
Start on Southwest 3rd Street
0.3 mi·40 sec·Southwest 3rd Street
2
Continue on Southeast 3rd Street
358 ft·16 sec·Southeast 3rd Street
3
Turn left onto Southeast Douglas Street
2.2 mi·4 min·Southeast Douglas Street
4
Take the ramp
0.2 mi·28 sec
Toward I 470 North: Independence, Saint Louis
5
Merge onto I 470
7.0 mi·8 min·I 470
Toward I 470 North: Saint Louis
6
Take the exit
0.4 mi·44 sec
Exit 16BToward I 70 East: Saint LouisUse the slight right lane.
The midpoint is around 146.7 miles from Lee's Summit, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel check
Top up before Dwight D. Eisenhower Highway if your tank is already low. That segment runs about 135.3 miles.
Arriving in Sainte Genevieve, MO
The final approach into Sainte Genevieve, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Sainte Genevieve, MO.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Nearby Places
Restaurants, cafes, gas stations and more along your route.
Top Restaurant
Cafe Genevieve
4.5
★ ★ ★ ★ ★
Ste. Genevieve, Missouri
Near the end, short detour
1.2 mi from route
~3 min detour
$10 to $20
mile 293.4
Hours: 10:30 am–8 pm
+15738833562
Cafe Genevieve
4.5
★ ★ ★ ★ ★
Near the end, short detour
1.2 mi from route
~3 min detour
$10 to $20
mile 293.4
Ste. Genevieve, Missouri
Hours: 10:30 am–8 pm
+15738833562
Cafe Poland by Iwona
4.8
★ ★ ★ ★ ★
Around the midpoint, ~11 min detour
4.5 mi from route
~11 min detour
$10 to $20
mile 125.7
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Ste. Geneviève National Historical Park
National Historical Park
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
12 mi from route
~30 min detour
$19
near mile 242.8
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $31 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
88
1
$30.81
$14.08
Efficient EV
73.4
0
$25.67
$11.74
EV Truck/SUV
117.4
1
$41.08
$18.78
Gas CO2
103 kg
EV CO2
34 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Lee's Summit, MO
Morning
in Lee's Summit on Saturday
Local time
6:54 AM
CDT
Current temp
73°F
Unavailable
Live forecast
Destination
Sainte Genevieve, MO
Morning
in Sainte Genevieve on Saturday
Local time
6:54 AM
CDT
Current temp
56°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
17 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 41m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Lee's Summit, MO to Sainte Genevieve, MO covers 293.4 miles and takes about 5h 41m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Police Officer Steven Jarvis Memorial Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 146.7 miles from Lee's Summit, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $45.87 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 20 significant decision points across 293.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 9.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 204.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 229.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
On the drive from Lee's Summit, MO to Sainte Genevieve, MO, road signs begin pointing toward Memphis along the way.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
