Sainte Genevieve, MO to Independence, MO is 289.9 miles and takes about 5h 38m via Dwight D Eisenhower Highway, with a fuel budget near $45 and enough daylight to finish in a day. This Midwest to Midwest drive is a single-day trip that covers ground efficiently. You'll experience a route that's mostly highway driving, making it a straightforward journey. With a recommended one-day drive, you can expect to arrive with plenty of time to spare. The modest fuel cost makes this a budget-friendly option for a quick connection between these two Missouri locations.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
145 miles from Sainte Genevieve, MO
A natural place for your longest stop of the day
, about 2h 55m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 38m. Total distance: 289.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 38m drive, comfortable solo distance.
Scenic Drive
Turn-heavy local drive route profile with national parks nearby.
Drive Character
This route offers a 20% highway share, meaning you'll encounter a mix of faster highway segments and more local, turn-heavy driving. The longest uninterrupted stretch you'll experience is 80.7 miles, primarily on the Dwight D Eisenhower Highway. Expect the road to transition from more urban or suburban interfaces to stretches that feel more like a local commute as you progress. The 'turn-heavy local drive' profile suggests you'll be navigating various intersections and potentially slower speeds in populated areas, so stay alert. This isn't a monotonous interstate cruise, but rather a dynamic drive that keeps you engaged.
This route has more turning and local-road decision points than a simple highway run.
There are about 33 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D Eisenhower Highway is the longest continuous segment at about 80.7 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 50.3 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 289.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 50.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 50.6 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 62.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 20 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
8
50.3 mi into trip|~1h in
Take the exit toward I 270 West, I 255 East: Kansas City, Chicago
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 196
Toward I 270 West, I 255 East: Kansas City, Chi...
8
50.6 mi into trip|~1h 1m in
Keep slight left at fork toward I 270 West: Kansas City
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left lane.
Toward I 270 West: Kansas City
8
62.9 mi into trip|~1h 16m in
Take the exit toward I 64, US 40, US 61: Wentzville, Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 12
Toward I 64, US 40, US 61: Wentzville, Saint Lo...
8
63 mi into trip|~1h 17m in
Keep slight left at fork toward I 64 West, US 40 West, US 61 North: Wentzville
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 64 West, US 40 West, US 61 North: Went...
8
88.9 mi into trip|~1h 49m in|US 40
Take the exit onto US 40 toward I 70 West, US 40 West: Kansas City
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Exit 1A
Toward I 70 West, US 40 West: Kansas City
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Sainte Genevieve, MO and Independence, MO, road signs point toward Chicago and Saint Louis.
Chicago
50.3 mi in|~1h
Saint Louis
62.9 mi in|~1h 16m
Main Roads
Road
Distance
Duration
Dwight D Eisenhower Highway
80.7 mi
1h 35m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Dwight D. Eisenhower Highway
54.3 mi
58m
I 55
40 mi
43m
Avenue of the Saints
25.4 mi
30m
I 270
11.5 mi
14m
US 61
7.3 mi
10m
South Noland Road
3 mi
5m
Longest stretch:
Dwight D Eisenhower Highway
— 80.7 mi, about 1h 35m
Turn-by-Turn Driving Directions
Step-by-step road directions between Sainte Genevieve, MO and Independence, MO.
1
Start on Jefferson Street
435 ft·24 sec·Jefferson Street
2
Turn left onto North Main Street
405 ft·12 sec·North Main Street
3
Turn right onto Merchant Street
0.2 mi·42 sec·Merchant Street
4
Turn left onto 3rd Street
347 ft·18 sec·3rd Street
5
Turn right onto Market Street
1.0 mi·2 min·Market Street
6
Turn right onto US 61
7.3 mi·10 min·US 61
7
Continue on MO O
0.2 mi·24 sec·MO O
8
Take the ramp
0.2 mi·28 sec
Toward I 55 North: Bloomsdale
9
Merge onto I 55
40 mi·43 min·I 55
10
Continue on I 55
1.3 mi·1 min·Rosa Parks Highway
11
Take the exit
0.2 mi·27 sec
Exit 196Toward I 270 West, I 255 East: Kansas City, ChicagoUse the slight right lane.
12
Keep slight left at fork
388 ft·8 sec
Toward I 270 West: Kansas CityUse the slight left lane.
13
Continue on this road
0.7 mi·1 min·this road
Exit 196Toward I 270 West
14
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
15
Take the exit
0.1 mi·17 sec
Exit 12Toward I 64, US 40, US 61: Wentzville, Saint LouisUse the slight right lane.
16
Keep slight left at fork
0.4 mi·48 sec
Toward I 64 West, US 40 West, US 61 North: WentzvilleUse the slight left lane.
17
Continue on this road
0.1 mi·9 sec·this road
Exit 12Toward I 64 West, US 40 West, US 61 North: Wentzville
18
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight lane.
19
Take the exit onto US 40
0.6 mi·1 min·US 40
Exit 1AToward I 70 West, US 40 West: Kansas CityUse the straight / slight left lanes.
20
Merge onto I 70; US 40
81 mi·1 hr 35 min·Dwight D Eisenhower Highway
21
Continue on I 70; US 40
2.0 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
22
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
23
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
24
Continue on I 70; US 40
54 mi·58 min·U.S. Submarine Veterans' Memorial Highway
Exit 12Toward Noland RoadUse the straight / slight right lanes.
29
Turn right onto South Noland Road
3.0 mi·5 min·South Noland Road
30
Turn left onto East Walnut Street
466 ft·22 sec·East Walnut Street
31
Turn right onto South Lynn Street
394 ft·22 sec·South Lynn Street
32
Turn left onto East Kansas Avenue
145 ft·6 sec·East Kansas Avenue
33
Arrive at destination
East Kansas Avenue
Trip Plan
Given the 5h 38m duration, starting your drive in Sainte Genevieve, MO, shortly after sunrise is ideal to maximize daylight. You can comfortably complete this 289.9-mile trip in one day, so no overnight stay is necessary. Plan for one main stop to break up the drive and refuel, keeping in mind the estimated $45 fuel cost. Pay attention to the highway share, as the 'turn-heavy local drive' profile means you'll need to be mindful of traffic signals and local speed limits, especially as you approach Independence, MO. Staying observant during these transitions will ensure a smoother arrival.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 145 miles from Sainte Genevieve, MO, or about 2h 55m into the drive.
The longest continuous stretch on this route runs about 80.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 64 miles or 1h 18m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 145 miles or 2h 55m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 38m
Traffic, exits, and arrival timing usually matter more near Independence, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Sainte Genevieve, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Sainte Genevieve, MO
This is one driving day of about 289.9 miles and 5h 38m.
Your first comfortable stop window is around 64 miles from Sainte Genevieve, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D Eisenhower Highway for about 80.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 145 mi from Sainte Genevieve, MO
· 2h 55m into the drive
The midpoint is around 144.6 miles from Sainte Genevieve, MO, which is a good place for a longer meal and fuel stop.
Arriving in Independence, MO
The final approach into Independence, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Independence, MO.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Ste. Geneviève National Historical Park
National Historical Park
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
13 mi from route
~31 min detour
$19
near mile 49.9
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$45.32 one way
$90.65 round trip
$3.97/gal25.4 MPG avg101 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$49.76
$99.52
premium
$4.89
$55.79
$111.58
diesel
$5.61
$64.01
$128.01
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$45
Meals
$25–$50
Total
$70–$95
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 101.4 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $30 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
87
1
$30.44
$13.92
Efficient EV
72.5
0
$25.37
$11.60
EV Truck/SUV
116
1
$40.59
$18.55
Gas CO2
101 kg
EV CO2
34 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
Sainte Genevieve, MO
Late night
in Sainte Genevieve on Saturday
Local time
3:55 AM
CDT
Current temp
56°F
Unavailable
Live forecast
Destination
Independence, MO
Late night
in Independence on Saturday
Local time
3:55 AM
CDT
Current temp
73°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
17 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 38m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Sainte Genevieve, MO to Independence, MO covers 289.9 miles and takes about 5h 38m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Dwight D. Eisenhower Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 145 miles from Sainte Genevieve, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $45.32 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 20 significant decision points across 289.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 50.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 50.6 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 62.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Sainte Genevieve, MO and Independence, MO, road signs point toward Chicago and Saint Louis.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
