The drive from O'Fallon, MO to Anderson, MO covers 304.3 miles and takes about 5h 47m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 44, I 49, MO 100 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 240.9 miles on I 44.
At current regular gas prices, budget about $47.57 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
152.2 miles from O'Fallon, MO
A natural place for your longest stop of the day
, about 3h into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 47m. Total distance: 304.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 47m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (95%). Some complex stretches to watch for.
Drive Character
This is a 5h 47m highway drive covering 304.3 miles, with most of the trip on I 44 and I 49. The longest continuous stretch is about 240.9 miles on I 44.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 27 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 44 is the longest continuous segment at about 240.9 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 44 and I 49. You will hit about 18 points where you need to pay attention to lane position or signs. The trickiest moment comes around 7 miles in.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 304.3 miles you will encounter 18 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 7 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 11 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 274.4 miles (I 49; US 71): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 18 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
7 mi into trip|~12m in
Take the ramp toward I 64 East, US 40 East, US 61 South
Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 64 East, US 40 East, US 61 South
7
11 mi into trip|~17m in
Take the exit toward Chesterfield Airport Road
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 14
Toward Chesterfield Airport Road
6
274.4 mi into trip|~5h 12m in|I 49; US 71
Take the exit onto I 49; US 71 toward I 49 South, US 71 South, MO 249 North: Neosho, Fort Smith
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 11
Toward I 49 South, US 71 South, MO 249 North: N...
6
274.7 mi into trip|~5h 13m in|I 49; US 71
Keep slight left at fork onto I 49; US 71 toward I 49 South, US 71 South: Neosho, Fort Smith
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 49 South, US 71 South: Neosho, Fort Sm...
6
298.7 mi into trip|~5h 39m in|US 71 Business
Take the exit onto US 71 Business toward MO 59, US 71 Business: Goodman, Anderson
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 16
Toward MO 59, US 71 Business: Goodman, Anderson
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from O'Fallon, MO to Anderson, MO, road signs begin pointing toward Fort Smith along the way.
Fort Smith
274.4 mi in|~5h 12m|via I 49; US 71
Main Roads
Road
Distance
Duration
I 44
240.9 mi
4h 19m
I 49
24.3 mi
26m
MO 100
13.3 mi
18m
MO K
6.5 mi
11m
US 71 Business
4.9 mi
6m
MO 109
4.7 mi
7m
Avenue of the Saints
3.7 mi
4m
North Eatherton Road
2.4 mi
4m
Longest stretch:
I 44
— 240.9 mi, about 4h 19m
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon, MO and Anderson, MO.
1
Start on this road
25 ft·7 sec·this road
2
Turn left onto South Main Street
0.5 mi·1 min·South Main Street
3
Continue on MO K
3.1 mi·5 min·MO K
Use the left lane.
4
Continue on MO K
3.4 mi·5 min·MO K
Use the straight lane.
5
Take the ramp
0.3 mi·21 sec
Toward I 64 East, US 40 East, US 61 SouthUse the slight right lane.
6
Merge onto I 64; US 40; US 61
3.7 mi·4 min·Avenue of the Saints
7
Take the exit
0.5 mi·57 sec
Exit 14Toward Chesterfield Airport RoadUse the slight right lane.
8
Continue on Chesterfield Airport Road
361 ft·6 sec·Chesterfield Airport Road
9
Turn right
211 ft·5 sec
Toward Olive Street Road
10
Turn right onto Olive Street Road
0.9 mi·1 min·Olive Street Road
11
Continue on North Eatherton Road
2.4 mi·4 min·North Eatherton Road
12
Enter roundabout onto MO 109
70 ft·1 sec·MO 109
13
Continue on MO 109
4.3 mi·6 min·MO 109
14
Enter roundabout onto MO 109
94 ft·2 sec·MO 109
15
Continue on MO 109
0.4 mi·44 sec·MO 109
16
Enter roundabout
76 ft·1 sec
Toward MO 100 West: Gray Summit
17
Continue
0.2 mi·32 sec
Toward MO 100 West: Gray Summit
18
Merge onto MO 100
13 mi·18 min·MO 100
19
Take the exit
0.2 mi·14 sec
Toward I 44 West, US 50 West: St. Clair
20
Merge onto I 44; US 50
241 mi·4 hr 19 min·I 44; US 50
Use the straight lane.
21
Take the exit onto I 49; US 71
0.3 mi·24 sec·I 49; US 71
Exit 11Toward I 49 South, US 71 South, MO 249 North: Neosho, Fort Smith
22
Keep slight left at fork onto I 49; US 71
24 mi·26 min·I 49; US 71
Toward I 49 South, US 71 South: Neosho, Fort Smith
23
Take the exit onto US 71 Business
0.3 mi·31 sec·US 71 Business
Exit 16Toward MO 59, US 71 Business: Goodman, Anderson
24
Continue on US 71 Business; MO 59
4.7 mi·5 min·US 71 Business; MO 59
25
Turn right onto MO 59; MO 76
0.5 mi·53 sec·North State Highway 59
26
Turn left onto Jefferson Street
0.1 mi·24 sec·Jefferson Street
27
Arrive at destination
East Street
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 152.2 miles from O'Fallon, MO, or about 3h into the drive.
The longest continuous stretch on this route runs about 240.9 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 67 miles or 1h 28m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 152.2 miles or 3h in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 45m
Traffic, exits, and arrival timing usually matter more near Anderson, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving O'Fallon, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from O'Fallon, MO
This is one driving day of about 304.3 miles and 5h 47m.
Your first comfortable stop window is around 67 miles from O'Fallon, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 44 for about 240.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 152.2 mi from O'Fallon, MO
· 3h into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
George Washington Carver National Monument
National Monument
The young child known as the "Plant Doctor" tended his secret garden while observing the day-to-day operations of a 19th century farm. Nature and nurture ultimately influenced George on his quest for...
5 mi from route
~13 min detour
Free
near mile 283.3
Wilson's Creek was the first major Civil War battle fought west of the Mississippi River, and where the first Union general was killed in action. The costly Southern victory on August 10, 1861, focuse...
7 mi from route
~19 min detour
Free
near mile 220.4
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $32 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
91.3
1
$31.95
$14.61
Efficient EV
76.1
0
$26.63
$12.17
EV Truck/SUV
121.7
1
$42.60
$19.48
Gas CO2
106 kg
EV CO2
36 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 18, 2026
Origin
O'Fallon, MO
Late night
in O'Fallon on Saturday
Local time
2:14 AM
CDT
Current temp
46°F
Rain Showers
NW 10 to 15 mph97% chanceLive forecast
Flood Warning
Flood Warning issued April 18 at 1:43AM CDT until April 18 at 10:45AM CDT by NWS Springfield MO
Flood Warning
Flood Warning issued April 18 at 1:07AM CDT until April 18 at 10:45AM CDT by NWS Springfield MO
Destination
Anderson, MO
Late night
in Anderson on Saturday
Local time
2:14 AM
CDT
Current temp
76°F
Unavailable
Live forecast
74°F
Washington, MO
152 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
30 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 47m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from O'Fallon, MO to Anderson, MO covers 304.3 miles and takes about 5h 47m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 44, I 49, MO 100. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 152.2 miles from O'Fallon, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $47.57 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This drive requires moderate attention. Across 304.3 miles you will encounter 18 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: at 7 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 11 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 274.4 miles (I 49; US 71): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
On the drive from O'Fallon, MO to Anderson, MO, road signs begin pointing toward Fort Smith along the way.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
