Origin
O'Fallon, MO
Afternoon in O'Fallon on Thursday
Local time
4:04 PM
CDT
Current temp
57°F
Unavailable
Live forecast
Trip from O'Fallon, MO to De Soto, MO
Last recalculated Apr 16, 2026
Drive Time
1h 25m
Distance
65.7 mi
106 km
Drive Score
9/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$10
one way
EV Charging
Unknown
Best Time to Leave
4 AM
1h 18m
★
6 AM
1h 25m
8 AM
1h 38m
10 AM
1h 30m
12 PM
1h 28m
3 PM
1h 30m
5 PM
1h 38m
8 PM
1h 21m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
O'Fallon, MO
Wikimedia Commons
De Soto, MO
Wikimedia Commons
Trip Overview
The drive from O'Fallon, MO to De Soto, MO covers 65.7 miles and takes about 1h 25m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Veterans Memorial Highway, I 270, I 70 for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 19.8 miles on Veterans Memorial Highway. At current regular gas prices, budget about $10.27 one way before food or hotel costs.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 1h 25m. Total distance: 65.7 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
1h 25m drive, comfortable solo distance.
EV Driver
0 DC fast chargers along the route. Coverage: unknown.
First-Time Driver
Mostly highway driving (64%). Some complex stretches to watch for.
Drive Character
This is a 1h 25m highway drive covering 65.7 miles, with most of the trip on Veterans Memorial Highway and I 270. The longest continuous stretch is about 19.8 miles on Veterans Memorial Highway.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 22 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Veterans Memorial Highway is the longest continuous segment at about 19.8 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on Veterans Memorial Highway and I 270. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 15.1 miles in.
Driving Effort
10/10
Demanding - stay alert through the decision-heavy sections
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 65.7 miles you will encounter 18 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 15.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 15.2 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 31.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Critical Maneuvers
5 of 18 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
8
15.1 mi into trip
|
~20m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 232
Toward I 270: Chicago, Memphis
7
15.2 mi into trip
|
~20m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
7
31.4 mi into trip
|
~40m in
Take the exit toward MO 30: Gravois Road
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 3
Toward MO 30: Gravois Road
8
31.7 mi into trip
|
~41m in
Keep slight right at fork toward MO 30 West: Fenton
Highway fork - watch signs carefully. Lane positioning matters here
Use the right lane.
Toward MO 30 West: Fenton
7
34.2 mi into trip
|
~44m in
Take the exit toward MO 141: Fenton, Valley Park
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the right lane.
Toward MO 141: Fenton, Valley Park
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between O'Fallon, MO and De Soto, MO, road signs point toward Memphis and Valley Park.
Memphis
15.1 mi in
|
~20m
Valley Park
34.2 mi in
|
~44m
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Veterans Memorial Highway | 19.8 mi | 23m |
| I 270 | 15.6 mi | 19m |
| I 70 | 13.5 mi | 16m |
| MO 21 | 4.4 mi | 6m |
| MO 141 | 4 mi | 5m |
| MO 30 | 2.4 mi | 3m |
| MO 110 | 1.5 mi | 1m |
| North Main Street | 1.4 mi | 2m |
Longest stretch:
Veterans Memorial Highway
— 19.8 mi, about 23m
Turn-by-Turn Driving Directions
Step-by-step road directions between O'Fallon, MO and De Soto, MO.
1
Start on this road
25 ft
·
7 sec
·
this road
2
Turn left onto South Main Street
0.6 mi
·
1 min
·
South Main Street
3
Turn left onto Drennen Parkway
0.9 mi
·
1 min
·
Drennen Parkway
Use the left lane.
4
Take the ramp
438 ft
·
6 sec
Toward I 70 East: Saint Louis
Use the slight left lane.
5
Merge onto I 70
14 mi
·
16 min
·
I 70
Use the straight / slight right lanes.
6
Take the exit
0.2 mi
·
12 sec
Exit 232
Toward I 270: Chicago, Memphis
Use the slight right lane.
7
Keep slight right at fork
0.4 mi
·
33 sec
Toward I 270 South: Memphis
Use the slight right lane.
8
Continue on this road
0.1 mi
·
10 sec
·
this road
Exit 232
Toward I 270 South: Memphis
9
Merge onto I 270
16 mi
·
19 min
·
I 270
Use the straight lane.
10
Take the exit
0.3 mi
·
33 sec
Exit 3
Toward MO 30: Gravois Road
Use the slight right lane.
11
Keep slight right at fork
306 ft
·
7 sec
Toward MO 30 West: Fenton
Use the right lane.
12
Merge onto MO 30
2.4 mi
·
3 min
·
MO 30
13
Take the exit
0.2 mi
·
27 sec
Toward MO 141: Fenton, Valley Park
Use the right lane.
14
Turn left onto MO 141
4.0 mi
·
5 min
·
MO 141
Use the left / straight lanes.
15
Take the exit
0.2 mi
·
13 sec
Toward MO 21 South: Hillsboro
16
Merge onto MO 21
20 mi
·
23 min
·
Veterans Memorial Highway
17
At end of road, turn left onto MO 21; MO B
0.5 mi
·
49 sec
·
MO 21; MO B
18
Continue on MO 21
3.9 mi
·
5 min
·
MO 21
19
Turn left onto MO 110
1.5 mi
·
1 min
·
MO 110
20
Turn right onto North Main Street
1.4 mi
·
2 min
·
North Main Street
21
Turn right onto Easton Street
435 ft
·
19 sec
·
Easton Street
22
Arrive at destination
Easton Street
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 32.8 mi from O'Fallon, MO · 42m into the drive
Mid-route town
Meal stop
33 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 14 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 32.8 miles from O'Fallon, MO, which is a good place for a longer meal and fuel stop.
Arriving in De Soto, MO
The final approach into De Soto, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$10.27 one way
$20.54 round trip
$3.97/gal
25.4 MPG avg
23 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $11.28 | $22.56 |
| premium | $4.89 | $12.64 | $25.29 |
| diesel | $5.61 | $14.51 | $29.01 |
No toll roads detected on this route.
Drive Cost (one way)
Fuel
$10
Estimated CO2 emission: 23 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $7 in charging · 0 stops · 65% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 19.7 | 0 | $6.90 | $3.15 |
| Efficient EV | 16.4 | 0 | $5.75 | $2.63 |
| EV Truck/SUV | 26.3 | 0 | $9.20 | $4.20 |
Gas CO2
23 kg
EV CO2
8 kg (65% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
De Soto, MO
Afternoon in De Soto on Thursday
Local time
4:04 PM
CDT
Current temp
55°F
Unavailable
Live forecast
57°F
Arnold, MO
33 mi in
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
1h 25m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from O'Fallon, MO to De Soto, MO covers 65.7 miles and takes about 1h 25m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Veterans Memorial Highway, I 270, I 70. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 32.8 miles from O'Fallon, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $10.27 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Leave by 9 AM and you'll arrive before lunch. Even a 4 PM departure gets you there before dark in summer.
This drive requires moderate attention. Across 65.7 miles you will encounter 18 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: at 15.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 15.2 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 31.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Between O'Fallon, MO and De Soto, MO, road signs point toward Memphis and Valley Park.
Yes. Nearby national parks include Gateway Arch National Park and Ste. Geneviève National Historical Park.
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