Origin
Senatobia, MS
Evening in Senatobia on Wednesday
Local time
8:12 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Trip from Senatobia, MS to City of Greenville, MS
Last recalculated Apr 16, 2026
Drive Time
2h 54m
Distance
135.7 mi
218 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$20
one way
Best Time to Leave
4 AM
2h 43m
★
6 AM
2h 55m
8 AM
3h 17m
10 AM
3h 2m
12 PM
3h 0m
3 PM
3h 3m
5 PM
3h 16m
8 PM
2h 48m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Senatobia, MS
Wikimedia Commons
City of Greenville, MS
Alex Borelli
Trip Overview
Traveling from Senatobia to Greenville covers 135.7 miles across the Mississippi Delta region. Expect to spend about 2 hours and 54 minutes behind the wheel, making this a very manageable day trip that doesn't require an overnight stay. Your journey will primarily utilize US 278, I-55, and MS 182 to navigate between these two Southeast locations. Budget roughly $21 for fuel to complete the transit. Whether you are heading out for business or a change of scenery, the straightforward nature of this route allows for a stress-free excursion. You can easily complete the entire trip in a single day, leaving plenty of time to explore once you arrive.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
67.9 miles from Senatobia, MS
A natural place for your longest stop of the day , about 1h 27m into the drive .
Drive Character
This highway-focused drive is defined by its efficiency, with 97% of your time spent on major thoroughfares. You will face a significant 101-mile stretch on US 278, which serves as the primary artery for your journey. The road feels consistent and reliable, moving you quickly across the landscape without the technical challenges of winding local backroads. Because the route relies heavily on high-speed highways, you should prepare for a steady, rhythmic pace. It is a functional drive that prioritizes speed and directness as you transition from Senatobia toward the Mississippi River.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 17 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 278 is the longest continuous segment at about 101 miles.
Elevation Profile
Mostly flat terrain
372 ft
122 ft
Total Climb
159 ft
Total Descent
321 ft
Highest Point
372 ft
~11.3 mi in
Elevation Range
251 ft
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 278 and I 55. You will hit about 13 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near US 51.
Route Complexity
5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
This drive requires moderate attention. Across 135.7 miles you will encounter 13 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (US 51): Navigation decision point; near the start (West Main Street): Sharp turn - reduce speed on approach; at 1 miles: Navigation decision point.
Critical Maneuvers
5 of 13 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
4
0 mi into trip
|
~0m in
|
US 51
Turn left onto US 51
Navigation decision point
4
0 mi into trip
|
~0m in
|
West Main Street
Turn sharp left onto West Main Street
Sharp turn - reduce speed on approach
3
1 mi into trip
|
~1m in
Take the ramp
Navigation decision point
5
22.8 mi into trip
|
~25m in
Keep slight right at fork
Highway fork - watch signs carefully
4
124 mi into trip
|
~2h 36m in
|
Griffin Road
Turn right onto Griffin Road
Navigation decision point
Main Roads
| Road | Distance | Duration |
|---|---|---|
| US 278 | 101 mi | 2h 10m |
| I 55 | 21.4 mi | 22m |
| MS 182 | 7.8 mi | 11m |
| North Broad Street | 1.4 mi | 2m |
| Martin Luther King Junior Boulevard | 1 mi | 1m |
| West Main Street | 1 mi | 1m |
| Old Hwy 61 | 0.8 mi | 1m |
| East Reed Road | 0.7 mi | 1m |
Longest stretch:
US 278
— 101 mi, about 2h 10m
Turn-by-Turn Driving Directions
Step-by-step road directions between Senatobia, MS and City of Greenville, MS.
1
Start on US 51
16 ft
·
0 sec
·
US 51
2
Turn left onto US 51
57 ft
·
2 sec
·
US 51
3
Turn sharp left onto West Main Street
1.0 mi
·
1 min
·
West Main Street
4
Take the ramp
0.2 mi
·
28 sec
5
Merge onto I 55
21 mi
·
22 min
·
I 55
6
Take the exit
0.2 mi
·
29 sec
7
Keep slight right at fork
0.1 mi
·
13 sec
8
Merge onto US 278; MS 6
36 mi
·
50 min
·
US 278; MS 6
9
Take the exit onto US 278
65 mi
·
1 hr 19 min
·
US 278
10
Turn right onto Griffin Road
145 ft
·
7 sec
·
Griffin Road
11
Turn left onto Old Hwy 61
0.8 mi
·
1 min
·
Old Hwy 61
12
Turn straight onto North Broad Street
1.4 mi
·
2 min
·
North Broad Street
13
Turn right onto MS 182
7.8 mi
·
11 min
·
MS 182
14
Turn left onto MS 1
1.0 mi
·
1 min
·
Martin Luther King Junior Boulevard
15
Turn right onto East Reed Road
0.7 mi
·
1 min
·
East Reed Road
16
Turn left onto Sandy Avenue
46 ft
·
2 sec
·
Sandy Avenue
17
Arrive at destination
Sandy Avenue
Trip Plan
Aim to depart in the morning to maximize your time in Greenville, especially since the drive is short enough to offer significant scheduling flexibility. Plan for at least one dedicated stop during your 2h 54m transit to break up the long 101-mile stretch on US 278. Keeping your fuel costs around $21 in mind, ensure you have a full tank before leaving Senatobia to avoid unnecessary refueling stops on the highway. Since this is a highway-heavy route, stay alert during the long sections on US 278 to maintain focus. Taking advantage of the single planned stop will help keep you refreshed for the arrival at your final destination.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 67.9 miles from Senatobia, MS, or about 1h 27m into the drive.
The longest continuous stretch on this route runs about 101 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 30 miles or 36m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 67.9 miles or 1h 27m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 20m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Senatobia, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Senatobia, MS
This is one driving day of about 135.7 miles and 2h 54m.
Your first comfortable stop window is around 30 miles from Senatobia, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 278 for about 101 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 67.9 mi from Senatobia, MS · 1h 27m into the drive
Mid-route town
Meal stop
68 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 30 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 67.9 miles from Senatobia, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before US 278 if your tank is already low. That segment runs about 101 miles.
Arriving in City of Greenville, MS
The final approach into City of Greenville, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around City of Greenville, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$20.49 one way
$40.99 round trip
$3.84/gal
25.4 MPG avg
48 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.21 | $22.50 | $44.99 |
| premium | $4.56 | $24.36 | $48.71 |
| diesel | $5.61 | $29.96 | $59.92 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$20
Meals
$25–$50
Total
$45–$70
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 47.5 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $14 in charging · 0 stops · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 40.7 | 0 | $14.25 | $6.51 |
| Efficient EV | 33.9 | 0 | $11.87 | $5.43 |
| EV Truck/SUV | 54.3 | 0 | $19.00 | $8.68 |
Gas CO2
47 kg
EV CO2
16 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
City of Greenville, MS
Evening in City of Greenville on Wednesday
Local time
8:12 PM
CDT
Current temp
86°F
Sunny
SSW 10 mph
1% chance
Live forecast
56°F
Shelby, MS
68 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
9 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 54m on the road
The weather snapshot is not static. If you are leaving later, give both cities one more quick forecast check before departure.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Senatobia, MS to City of Greenville, MS covers 135.7 miles and takes about 2h 54m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 278, I 55, MS 182. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 67.9 miles from Senatobia, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $20.49 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Leave by 9 AM and you'll arrive before lunch. Even a 4 PM departure gets you there before dark in summer.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
This drive requires moderate attention. Across 135.7 miles you will encounter 13 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: near the start (US 51): Navigation decision point; near the start (West Main Street): Sharp turn - reduce speed on approach; at 1 miles: Navigation decision point.
The route from Senatobia, MS to City of Greenville, MS does not surface many named destination signs beyond the main corridor.
Mostly flat terrain. The route ranges from 122 ft to 372 ft elevation with about 159 ft of total climbing.
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