Drive Time
2h 54m
Distance
135.7 mi
218 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$21
one way
Photo: Alex Borelli
The drive from Senatobia, MS to City of Greenville, MS covers 135.7 miles and takes about 2h 54m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 278, I 55, MS 182 for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 101 miles on US 278. At current regular gas prices, budget about $20.75 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
67.9 miles from Senatobia, MS
A natural place for your longest stop of the day , about 1h 27m into the drive .
This is a 2h 54m highway drive covering 135.7 miles, with most of the trip on US 278 and I 55. The longest continuous stretch is about 101 miles on US 278.
Mostly flat terrain
Total Climb
159 ft
Total Descent
321 ft
Highest Point
372 ft
~11.3 mi in
Elevation Range
251 ft
This is a straightforward highway drive that stays mostly on US 278 and I 55. You will hit about 13 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near US 51.
Moderate - straightforward overall, but long enough or busy enough to require pacing
This drive requires moderate attention. Across 135.7 miles you will encounter 13 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (US 51): Navigation decision point; near the start (West Main Street): Sharp turn - reduce speed on approach; at 1 miles: Navigation decision point.
These are the spots where you need to pay the most attention. Preview them before you drive.
Turn left onto US 51
Navigation decision point
Turn sharp left onto West Main Street
Sharp turn - reduce speed on approach
Take the ramp
Navigation decision point
Keep slight right at fork
Highway fork - watch signs carefully
Turn right onto Griffin Road
Navigation decision point
| Road | Distance | Duration |
|---|---|---|
| US 278 | 101 mi | 2h 10m |
| I 55 | 21.4 mi | 22m |
| MS 182 | 7.8 mi | 11m |
| North Broad Street | 1.4 mi | 2m |
| Martin Luther King Junior Boulevard | 1 mi | 1m |
| West Main Street | 1 mi | 1m |
| Old Hwy 61 | 0.8 mi | 1m |
| East Reed Road | 0.7 mi | 1m |
Step-by-step road directions between Senatobia, MS and City of Greenville, MS.
Start on US 51
Turn left onto US 51
Turn sharp left onto West Main Street
Take the ramp
Merge onto I 55
Take the exit
Keep slight right at fork
Merge onto US 278; MS 6
Take the exit onto US 278
Turn right onto Griffin Road
Turn left onto Old Hwy 61
Turn straight onto North Broad Street
Turn right onto MS 182
Turn left onto MS 1
Turn right onto East Reed Road
Turn left onto Sandy Avenue
Arrive at destination
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 42m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 67.9 miles or 1h 27m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 20m
Traffic, exits, and arrival timing usually matter more near City of Greenville, MS than in the middle of the route.
Open the route before leaving Senatobia, MS so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Senatobia, MS
This is one driving day of about 135.7 miles and 2h 54m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 67.9 mi from Senatobia, MS · 1h 27m into the drive
Mid-route town
Meal stop
68 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 67.9 miles from Senatobia, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before US 278 if your tank is already low. That segment runs about 101 miles.
The final approach into City of Greenville, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around City of Greenville, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$20.75 one way
$41.49 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.26 | $22.75 | $45.51 |
| premium | $4.61 | $24.63 | $49.26 |
| diesel | $5.64 | $30.15 | $60.30 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$21
Meals
$25–$50
Total
$46–$71
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 47.5 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $14 in charging · 0 stops · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 40.7 | 0 | $14.25 | $6.51 |
| Efficient EV | 33.9 | 0 | $11.87 | $5.43 |
| EV Truck/SUV | 54.3 | 0 | $19.00 | $8.68 |
Gas CO2
47 kg
EV CO2
16 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Late night in Senatobia on Sunday
Local time
2:32 AM
CDT
Current temp
65°F
Forecast unavailable right now
Destination
Late night in City of Greenville on Sunday
Local time
2:32 AM
CDT
Current temp
68°F
Forecast unavailable right now
Along the Route
64°F
Dermott, AR
68 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
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