Trip from Tupelo, MS to Glendale, MS

Last recalculated Apr 15, 2026

Drive Time

4h 22m

Distance

227.4 mi

366 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$34

one way

Best Time to Leave

Save up to 40 min

4 AM

4h 9m ★

6 AM

4h 23m

8 AM

4h 49m

10 AM

4h 32m

12 PM

4h 29m

3 PM

4h 33m

5 PM

4h 48m

8 PM

4h 15m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly

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Tupelo, MS

Wikimedia Commons

Glendale, MS

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Trip Overview

This 227.4-mile drive from Tupelo, Mississippi, to Glendale, Mississippi, is best tackled in a single day, taking approximately 4 hours and 22 minutes. You'll primarily be on I-59 and US Highway 45 Alternate, with 94% of the journey on highways, making it a straightforward, highway-focused trip. With an estimated fuel cost of $34, it's an economical option for a quick getaway within the Southeast region. This route is designed for efficient travel, allowing you to cover a good distance without needing an overnight stop.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

113.7 miles from Tupelo, MS

A natural place for your longest stop of the day , about 2h 15m into the drive .

Drive Character

Expect a predominantly highway experience on this route, with 94% of your travel occurring on high-speed roads like I-59 and US Highway 45 Alternate. The longest uninterrupted stretch you'll encounter is 78 miles on I-59, offering a chance to settle into a rhythm. While largely highway-focused, be aware that US Highway 45 Alternate may present a slightly different driving feel as you transition. Overall, this drive is characterized by its efficiency and ease of navigation for most of its 227.4 miles.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.

There are about 24 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

I 59 is the longest continuous segment at about 78 miles.

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on I 59 and US Highway 45 Aiternate. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near Court Street.

Route Complexity 7/10

Demanding - plan breaks and stay ahead of the key maneuvers

This is a demanding drive. With 11 significant decision points across 227.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: near the start (Court Street): Navigation decision point; at 0.1 miles (East Main Street): Lane positioning matters here; at 147 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.

Critical Maneuvers

5 of 11 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

0 mi into trip | ~0m in | Court Street

Turn right onto Court Street

Navigation decision point

0.1 mi into trip | ~0m in | East Main Street

Turn left onto East Main Street

Lane positioning matters here

Use the left lane.

147 mi into trip | ~2h 54m in | I 59

Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left / slight right lanes. Toward I 59 South: Laurel, New Orleans

225 mi into trip | ~4h 18m in

Take the exit toward MS 42 East: Evelyn Gandy Parkway, Petal

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the straight / slight right lanes. Toward MS 42 East: Evelyn Gandy Parkway, Petal

225.6 mi into trip | ~4h 20m in | MS 42 / Evelyn Gandy Parkway

Turn left onto MS 42 / Evelyn Gandy Parkway

Lane positioning matters here

Use the straight lane.

Towns Mentioned on Route Signs

Based on OSRM destination-sign hints, not a full list of every settlement the road passes.

On the drive from Tupelo, MS to Glendale, MS, road signs begin pointing toward New Orleans along the way.

New Orleans

147 mi in | ~2h 54m | via I 59

Main Roads

Road	Distance	Duration
I 59	78 mi	1h 24m
US Highway 45 Aiternate	60.6 mi	1h 9m
US Highway 45 Alternate	54.7 mi	1h 6m
Martin Luther King Drive	8.7 mi	10m
I 20	8.1 mi	9m
US 45 ALT	7.2 mi	8m
US 45	3.9 mi	4m
Martin Luther King, Junior Drive	2.3 mi	2m

Longest stretch: I 59 — 78 mi, about 1h 24m

Turn-by-Turn Driving Directions

Step-by-step road directions between Tupelo, MS and Glendale, MS.

Start on North Spring Street

68 ft · 5 sec · North Spring Street

Turn right onto Court Street

317 ft · 16 sec · Court Street

Turn right onto North Front Street

287 ft · 15 sec · North Front Street

Turn left onto East Main Street

0.5 mi · 1 min · East Main Street

Use the left lane.

Take the ramp

0.4 mi · 55 sec

Merge onto US 45; MS 6

1.0 mi · 1 min · Martin Luther King Drive

Continue on US 45; MS 6

2.3 mi · 2 min · Martin Luther King, Junior Drive

Continue on US 45; US 278

7.7 mi · 8 min · Martin Luther King Drive

Continue on US 45 ALT

1.4 mi · 1 min · US 45 ALT

Continue on US 45 ALT

2.2 mi · 2 min · US 45 ALT

Continue on US 45 ALT

1.5 mi · 1 min · US 45 ALT

Continue on US 45 ALT

0.7 mi · 49 sec · US 45 ALT

Continue on US 45 ALT

1.4 mi · 1 min · US 45 ALT

Continue on US 45 ALT

55 mi · 1 hr 6 min · US Highway 45 Alternate

Use the straight lane.

Continue on US 45

61 mi · 1 hr 9 min · US Highway 45 Aiternate

Keep slight right at fork onto US 45

3.9 mi · 4 min · US 45

Take the exit

0.5 mi · 1 min

Toward I 59 South, I 20 West: Meridian

Merge onto I 20; I 59

6.3 mi · 7 min · I 20; I 59

Use the straight / slight right lanes.

Continue on I 20; I 59; US 80

1.8 mi · 2 min · I 20; I 59; US 80

Use the straight lane.

Keep slight left at fork onto I 59

78 mi · 1 hr 24 min · I 59

Toward I 59 South: Laurel, New Orleans Use the slight left / slight right lanes.

Take the exit

0.6 mi · 1 min

Toward MS 42 East: Evelyn Gandy Parkway, Petal Use the straight / slight right lanes.

Turn left onto MS 42

1.8 mi · 2 min · Evelyn Gandy Parkway

Use the straight lane.

Turn right onto Glendale Avenue

246 ft · 8 sec · Glendale Avenue

Arrive at destination

Glendale Avenue

Trip Plan

Given the 4-hour 22-minute duration, departing Tupelo in the morning is ideal to arrive in Glendale with plenty of daylight. You'll have one main stretch of 78 miles on I-59 where stops are less frequent, so ensure you're fueled up before embarking on that segment. While you can complete this 227.4-mile trip in one day, the flexibility of a shorter duration means you can take your time and make brief stops if needed. Keep an eye on your fuel gauge, as the estimated cost is $34, and plan your refills accordingly, especially before merging onto longer highway stretches.

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 113.7 miles from Tupelo, MS, or about 2h 15m into the drive.

The longest continuous stretch on this route runs about 78 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 50 miles or 1h 1m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 113.7 miles or 2h 15m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 3h 37m

Traffic, exits, and arrival timing usually matter more near Glendale, MS than in the middle of the route.

Before You Leave

Open the route before leaving Tupelo, MS so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Tupelo, MS

This is one driving day of about 227.4 miles and 4h 22m.

Your first comfortable stop window is around 50 miles from Tupelo, MS.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

The longest stretch is on I 59 for about 78 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 113.7 mi from Tupelo, MS · 2h 15m into the drive

Mid-route town

Meal stop

Meridian, MS

114 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Columbus, MS

Fuel and coffee

A short stop after about 50 miles helps settle the day before fatigue starts building.

Macon, MS

Meal break

The midpoint is around 113.7 miles from Tupelo, MS, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before I 59 if your tank is already low. That segment runs about 78 miles.

Arriving in Glendale, MS

The final approach into Glendale, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Glendale, MS.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$34.34 one way

$68.69 round trip

$3.84/gal 25.4 MPG avg 80 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.21	$37.70	$75.40
premium	$4.56	$40.82	$81.63
diesel	$5.61	$50.21	$100.41

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$34

Meals

$25–$50

Total

$59–$84

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 79.6 kg one way. Prices: EIA weekly data, 2026-04-13.

Driving Electric?

About $24 in charging · 0 stops · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	68.2	0	$23.88	$10.92
Efficient EV	56.9	0	$19.90	$9.10
EV Truck/SUV	91	1	$31.84	$14.55

Gas CO2

80 kg

EV CO2

27 kg (66% less)

Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast as of Apr 15, 2026

Origin

Tupelo, MS

Evening in Tupelo on Wednesday

Local time

6:33 PM

CDT

Current temp

78°F

Unavailable

Live forecast

Destination

Glendale, MS

Evening in Glendale on Wednesday

Local time

6:33 PM

CDT

Current temp

63°F

Unavailable

Live forecast

79°F

Meridian, MS

114 mi in

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

15 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

4h 22m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Tupelo, MS to Glendale, MS covers 227.4 miles and takes about 4h 22m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are I 59, US Highway 45 Aiternate, US Highway 45 Alternate. Most of the drive stays on highways, so watch for ramps and exits.

This is a comfortable same-day trip.

The midpoint is about 113.7 miles from Tupelo, MS. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $34.34 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.

Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

On the drive from Tupelo, MS to Glendale, MS, road signs begin pointing toward New Orleans along the way.

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