The drive from Tutwiler, MS to Biloxi, MS covers 301.7 miles and takes about 6h 21m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Highway 49 South, East Street, US 49 for much of the mileage,
and the overall profile is mixed drive.
The longest uninterrupted segment is about 80.3 miles on Highway 49 South.
At current regular gas prices, budget about $45.56 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
150.8 miles from Tutwiler, MS
A natural place for your longest stop of the day
, about 3h 17m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 21m. Total distance: 301.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 21m drive, plan rest stops for pacing.
Scenic Drive
Mixed drive route profile with national parks nearby.
Drive Character
The drive from Tutwiler, MS to Biloxi, MS covers 301.7 miles and takes about 6h 21m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 30 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Highway 49 South is the longest continuous segment at about 80.3 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near Hancock Avenue.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 21 significant decision points across 301.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (Hancock Avenue): Sharp turn - reduce speed on approach; at 222.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 230.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 21 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
0 mi into trip|~0m in|Hancock Avenue
Turn sharp right onto Hancock Avenue
Sharp turn - reduce speed on approach
7
222.2 mi into trip|~4h 44m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
230.3 mi into trip|~4h 53m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
233.5 mi into trip|~4h 57m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
233.8 mi into trip|~4h 58m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Tutwiler, MS and Biloxi, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Mobile - among others.
Meridian
139.1 mi in|~3h 2m|via I 20; US 49
Hattiesburg
139.1 mi in|~3h 2m|via I 20; US 49
Richland
139.7 mi in|~3h 3m|via US 49
Gulf Coast
222.2 mi in|~4h 44m
Mississippi Gulf Coast
222.6 mi in|~4h 45m|via I 59
Mobile
230.3 mi in|~4h 53m|via US 98
Gulfport
233.5 mi in|~4h 57m
Multi Purpose Center
233.8 mi in|~4h 58m
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
East Street
74.7 mi
1h 37m
US 49
53.6 mi
1h 5m
Jerry Clower Boulevard
38.8 mi
47m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
Highway 49
14.6 mi
21m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
US 98
3.2 mi
4m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Turn-by-Turn Driving Directions
Step-by-step road directions between Tutwiler, MS and Biloxi, MS.
1
Start on Front Street
244 ft·17 sec·Front Street
2
Turn sharp right onto Hancock Avenue
0.3 mi·1 min·Hancock Avenue
3
Turn slight right onto US 49; MS 3
0.2 mi·20 sec·US 49; MS 3
4
Keep slight right at fork onto US 49W
15 mi·21 min·Highway 49
5
Continue on US 49W
75 mi·1 hr 37 min·East Street
6
Keep slight right at fork onto US 49W
0.5 mi·53 sec·US 49W
Toward US 49 South: Jackson
7
Merge onto US 49
39 mi·47 min·Jerry Clower Boulevard
8
Take the exit onto US 49
4.9 mi·5 min·US 49
9
Keep slight left at fork onto US 49
3.8 mi·5 min·US 49
10
Merge onto I 20; I 55; US 49
1.1 mi·1 min·I 20; I 55; US 49
11
Keep slight right at fork onto I 20; US 49
347 ft·4 sec·I 20; US 49
Toward Meridian, Hattiesburg
12
Take the exit onto US 49
0.6 mi·42 sec·US 49
Toward Hattiesburg
13
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
14
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
15
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
16
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
17
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
18
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
19
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
20
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
21
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
22
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
23
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
24
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
25
Continue on I 110
3.2 mi·4 min·I 110
26
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
27
Turn left onto Division Street
0.6 mi·1 min·Division Street
28
Turn right onto Main Street
0.5 mi·1 min·Main Street
29
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
30
Arrive at destination
Howard Avenue
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 150.8 miles from Tutwiler, MS, or about 3h 17m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 66 miles or 1h 30m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 150.8 miles or 3h 17m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 14m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Tutwiler, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Tutwiler, MS
This is one driving day of about 301.7 miles and 6h 21m.
Your first comfortable stop window is around 66 miles from Tutwiler, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 150.8 mi from Tutwiler, MS
· 3h 17m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~10 min detour
Free
near mile 135.2
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $32 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
90.5
1
$31.68
$14.48
Efficient EV
75.4
0
$26.40
$12.07
EV Truck/SUV
120.7
1
$42.24
$19.31
Gas CO2
106 kg
EV CO2
35 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Tutwiler, MS
Morning
in Tutwiler on Friday
Local time
6:25 AM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Biloxi, MS
Morning
in Biloxi on Friday
Local time
6:25 AM
CDT
Current temp
61°F
Unavailable
Live forecast
55°F
Florence, MS
151 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 21m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Tutwiler, MS to Biloxi, MS covers 301.7 miles and takes about 6h 21m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Highway 49 South, East Street, US 49. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 150.8 miles from Tutwiler, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $45.56 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 21 significant decision points across 301.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: near the start (Hancock Avenue): Sharp turn - reduce speed on approach; at 222.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 230.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Tutwiler, MS and Biloxi, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Mobile - among others.
How this page is built
Compiled and maintained by the Trip.ovh planning team at COD Solutions Oy (Helsinki). Each route is built from authoritative open government and mapping datasets rather than crowdsourced reviews. Distances and geometry come from
OSRM
over
OpenStreetMap.
Fuel cost uses
EIA
weekly regional averages.
EV charging comes from the
NREL Alternative Fuels
dataset.
National park proximity is from the
NPS API.
Pages are published only after passing our data-quality checks; our
methodology page
documents refresh cadence, editorial standards, and known limitations.
