The drive from Tylertown, MS to Tupelo, MS covers 281 miles and takes about 5h 29m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 59, US 45, US Highway 45 Alternate for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 91 miles on I 59.
At current regular gas prices, budget about $42.44 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
140.5 miles from Tylertown, MS
A natural place for your longest stop of the day
, about 2h 43m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 29m. Total distance: 281 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 29m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (92%). Some complex stretches to watch for.
Drive Character
This is a 5h 29m highway drive covering 281 miles, with most of the trip on I 59 and US 45. The longest continuous stretch is about 91 miles on I 59.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 20 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 59 is the longest continuous segment at about 91 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 59 and US 45. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 2.9 miles in near US 98.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 11 significant decision points across 281 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 2.9 miles (US 98): Lane positioning matters here; at 50.5 miles: Navigation decision point; at 133 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 11 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
2.9 mi into trip|~4m in|US 98
Turn right onto US 98
Lane positioning matters here
Use the straight lane.
5
50.5 mi into trip|~1h 4m in
Take the ramp toward I 59 North: Laurel
Navigation decision point
Toward I 59 North: Laurel
8
133 mi into trip|~2h 34m in|I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
6
141.9 mi into trip|~2h 44m in
Take the exit toward US 45 North: Macon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Toward US 45 North: Macon
8
207.3 mi into trip|~3h 59m in|US 45 ALT / US Highway 45 Alternate
Keep slight left at fork onto US 45 ALT / US Highway 45 Alternate toward US 45 Alternate North: West Point, Tupelo
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Toward US 45 Alternate North: West Point, Tupel...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Tylertown, MS to Tupelo, MS, road signs begin pointing toward Tuscaloosa along the way.
Tuscaloosa
133 mi in|~2h 34m|via I 59
Main Roads
Road
Distance
Duration
I 59
91 mi
1h 39m
US 45
65.1 mi
1h 14m
US Highway 45 Alternate
53 mi
1h 3m
US 98
47.6 mi
1h
Martin Luther King Drive
18.1 mi
20m
Old Hwy 98 East
2 mi
3m
Martin Luther King, Junior Drive
1.5 mi
2m
Beulah Avenue
0.9 mi
1m
Longest stretch:
I 59
— 91 mi, about 1h 39m
Turn-by-Turn Driving Directions
Step-by-step road directions between Tylertown, MS and Tupelo, MS.
1
Start on MS 48; MS 198
0.9 mi·1 min·Beulah Avenue
2
Continue on MS 198
2.0 mi·3 min·Old Hwy 98 East
3
Turn right onto US 98
44 mi·53 min·US 98
Use the straight lane.
4
Continue on US 98
0.8 mi·1 min·US 98
Use the straight lane.
5
Continue on US 98
0.5 mi·39 sec·US 98
Use the straight lane.
6
Continue on US 98
0.3 mi·26 sec·US 98
Use the left lane.
7
Continue on US 98
2.4 mi·4 min·US 98
Use the straight lane.
8
Take the ramp
0.5 mi·1 min
Toward I 59 North: Laurel
9
Merge onto I 59
82 mi·1 hr 28 min·I 59
Use the straight / slight right lanes.
10
Keep slight right at fork onto I 59
9.0 mi·10 min·I 59
Toward I 59 North, I 20 East: Meridian, TuscaloosaUse the straight lane.
11
Take the exit
0.3 mi·47 sec
Toward US 45 North: MaconUse the slight right lane.
12
Merge onto US 45
65 mi·1 hr 14 min·US 45
Use the straight lane.
13
Keep slight left at fork onto US 45 ALT
53 mi·1 hr 3 min·US Highway 45 Alternate
Toward US 45 Alternate North: West Point, TupeloUse the straight / slight left lanes.
14
Continue on US 45 ALT
18 mi·20 min·Martin Luther King Drive
15
Continue on US 45; MS 6
1.5 mi·2 min·Martin Luther King, Junior Drive
16
Take the exit onto MS 6
0.4 mi·49 sec·MS 6
Toward MS 6 East: Downtown Tupelo
17
Keep slight left at fork
170 ft·7 sec
18
Turn left onto MS 6
0.7 mi·1 min·East Main Street
Use the straight lane.
19
Turn right onto North Spring Street
230 ft·10 sec·North Spring Street
20
Arrive at destination
North Spring Street
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 140.5 miles from Tylertown, MS, or about 2h 43m into the drive.
The longest continuous stretch on this route runs about 91 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 62 miles or 1h 17m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 140.5 miles or 2h 43m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 27m
Traffic, exits, and arrival timing usually matter more near Tupelo, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Tylertown, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Tylertown, MS
This is one driving day of about 281 miles and 5h 29m.
Your first comfortable stop window is around 62 miles from Tylertown, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 59 for about 91 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 140.5 mi from Tylertown, MS
· 2h 43m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$42.44 one way
$84.88 round trip
$3.84/gal25.4 MPG avg98 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$46.59
$93.17
premium
$4.56
$50.44
$100.87
diesel
$5.61
$62.04
$124.08
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$42
Meals
$25–$50
Total
$67–$92
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 98.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
3 DC fast chargers
· Coverage: fair
EV Connect Charging Station
Tupelo, Mississippi
EV Connect
1 DCFC
ChargePoint Charging Station
Tupelo, Mississippi
ChargePoint
1 DCFC
ChargePoint Charging Station
Tupelo, Mississippi
ChargePoint
1 DCFC
ChargePoint: 2
EV Connect: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $30 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
84.3
1
$29.50
$13.49
Efficient EV
70.3
0
$24.59
$11.24
EV Truck/SUV
112.4
1
$39.34
$17.98
Gas CO2
98 kg
EV CO2
33 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Tylertown, MS
Morning
in Tylertown on Saturday
Local time
8:40 AM
CDT
Current temp
56°F
Unavailable
Live forecast
Destination
Tupelo, MS
Morning
in Tupelo on Saturday
Local time
8:40 AM
CDT
Current temp
78°F
Unavailable
Live forecast
79°F
Meridian, MS
141 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
22 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 29m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Tylertown, MS to Tupelo, MS covers 281 miles and takes about 5h 29m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 59, US 45, US Highway 45 Alternate. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 140.5 miles from Tylertown, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $42.44 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 11 significant decision points across 281 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 2.9 miles (US 98): Lane positioning matters here; at 50.5 miles: Navigation decision point; at 133 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
On the drive from Tylertown, MS to Tupelo, MS, road signs begin pointing toward Tuscaloosa along the way.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
