The drive from Byram, MS to Biloxi, MS covers 160.8 miles and takes about 3h 20m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Highway 49 South, US 49, Biloxi-D'Iberville Scenic Expressway for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 72 miles on Highway 49 South.
At current regular gas prices, budget about $24.28 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
80.4 miles from Byram, MS
A natural place for your longest stop of the day
, about 1h 41m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 3h 20m. Total distance: 160.8 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 20m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (89%). Some complex stretches to watch for.
Drive Character
This is a 3h 20m highway drive covering 160.8 miles, with most of the trip on Highway 49 South and US 49. The longest continuous stretch is about 72 miles on Highway 49 South.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 24 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Highway 49 South is the longest continuous segment at about 72 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on Highway 49 South and US 49. You will hit about 11 points where you need to pay attention to lane position or signs. The trickiest moment comes around 81.3 miles in.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 160.8 miles you will encounter 11 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 81.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 81.7 miles (I 59 / Lance Corporal Roy M Wheat Memorial Highway): Merge point - match speed before joining. Lane positioning matters here; at 89.5 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 11 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
7
81.3 mi into trip|~1h 43m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
6
81.7 mi into trip|~1h 44m in|I 59 / Lance Corporal Roy M Wheat Memorial Highway
Merge onto I 59 / Lance Corporal Roy M Wheat Memorial Highway toward Mississippi Gulf Coast
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
Toward Mississippi Gulf Coast
7
89.5 mi into trip|~1h 52m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
92.6 mi into trip|~1h 56m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
92.9 mi into trip|~1h 57m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Byram, MS and Biloxi, MS, road signs point toward Gulf Coast, Mississippi Gulf Coast, Mobile, Gulfport, Multi Purpose Center and Hattiesburg.
Gulf Coast
81.3 mi in|~1h 43m
Mississippi Gulf Coast
81.7 mi in|~1h 44m|via I 59
Mobile
89.5 mi in|~1h 52m|via US 98
Gulfport
92.6 mi in|~1h 56m
Multi Purpose Center
92.9 mi in|~1h 57m
Hattiesburg
92.9 mi in|~1h 57m
Main Roads
Road
Distance
Duration
Highway 49 South
72 mi
1h 25m
US 49
43.4 mi
51m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
Florence Byram Road
3.7 mi
6m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
West Main Street
1.7 mi
4m
Longest stretch:
Highway 49 South
— 72 mi, about 1h 25m
Turn-by-Turn Driving Directions
Step-by-step road directions between Byram, MS and Biloxi, MS.
1
Start on South Siwell Road
66 ft·1 sec·South Siwell Road
2
Continue on Old Byram Road
0.1 mi·15 sec·Old Byram Road
3
Continue on Swinging Bridge Road
0.4 mi·45 sec·Swinging Bridge Road
4
Continue on Florence-Byram Road
1.4 mi·2 min·Florence-Byram Road
5
Continue on Florence Byram Road
3.7 mi·6 min·Florence Byram Road
6
Continue on West Main Street
1.7 mi·4 min·West Main Street
7
Continue on MS 469
0.4 mi·41 sec·MS 469
8
Turn right onto US 49
72 mi·1 hr 25 min·Highway 49 South
Use the straight lane.
9
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
10
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
11
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
12
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
13
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
14
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
15
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
16
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
17
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
18
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
19
Continue on I 110
3.2 mi·4 min·I 110
20
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
21
Turn left onto Division Street
0.6 mi·1 min·Division Street
22
Turn right onto Main Street
0.5 mi·1 min·Main Street
23
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
24
Arrive at destination
Howard Avenue
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 80.4 miles from Byram, MS, or about 1h 41m into the drive.
The longest continuous stretch on this route runs about 72 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 35 miles or 47m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 80.4 miles or 1h 41m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 43m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Byram, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Byram, MS
This is one driving day of about 160.8 miles and 3h 20m.
Your first comfortable stop window is around 35 miles from Byram, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 72 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 80.4 mi from Byram, MS
· 1h 41m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$24.28 one way
$48.57 round trip
$3.84/gal25.4 MPG avg56 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$26.66
$53.32
premium
$4.56
$28.86
$57.72
diesel
$5.61
$35.50
$71.01
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$24
Meals
$25–$50
Total
$49–$74
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 56.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
9 DC fast chargers
· Coverage: excellent
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Eaton Charging Station
Ocean Springs, Mississippi
Other
1 DCFC
ChargePoint Charging Station
D'Iberville, Mississippi
ChargePoint
1 DCFC
Other: 4
Tesla Destination: 4
ChargePoint: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $17 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
48.2
0
$16.88
$7.72
Efficient EV
40.2
0
$14.07
$6.43
EV Truck/SUV
64.3
0
$22.51
$10.29
Gas CO2
56 kg
EV CO2
19 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Byram, MS
Morning
in Byram on Friday
Local time
11:38 AM
CDT
Current temp
55°F
Unavailable
Live forecast
Destination
Biloxi, MS
Morning
in Biloxi on Friday
Local time
11:38 AM
CDT
Current temp
61°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
6 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 20m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Byram, MS to Biloxi, MS covers 160.8 miles and takes about 3h 20m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Highway 49 South, US 49, Biloxi-D'Iberville Scenic Expressway. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 80.4 miles from Byram, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $24.28 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
This drive requires moderate attention. Across 160.8 miles you will encounter 11 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: at 81.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 81.7 miles (I 59 / Lance Corporal Roy M Wheat Memorial Highway): Merge point - match speed before joining. Lane positioning matters here; at 89.5 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Byram, MS and Biloxi, MS, road signs point toward Gulf Coast, Mississippi Gulf Coast, Mobile, Gulfport, Multi Purpose Center and Hattiesburg.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
