The drive from East Independence, MO to Glendale, MO covers 416.2 miles and takes about 8h 8m behind the wheel.
It usually feels better as a 2-day road trip than as one long push.
The route leans on Police Officer Steven Jarvis Memorial Highway, Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway for much of the mileage,
and the overall profile is turn-heavy local drive.
The longest uninterrupted segment is about 160.1 miles on Police Officer Steven Jarvis Memorial Highway.
At current regular gas prices, budget about $65.07 one way before food or hotel costs.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
208.1 miles from East Independence, MO
A natural place for your longest stop of the day
, about 4h into the drive
.
Who Is This Route For?
Solo Traveler
8h 8m drive, plan rest stops for pacing.
Scenic Drive
Turn-heavy local drive route profile with national parks nearby.
Drive Character
Expect a 8h 8m drive with frequent turns across 416.2 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 34 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Police Officer Steven Jarvis Memorial Highway is the longest continuous segment at about 160.1 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 5 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 22 significant decision points across 416.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 22 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
8
5 mi into trip|~10m in
Take the ramp toward Little Blue Parkway, 39th Street, Mall Entrance
Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Exit 17
Toward Little Blue Parkway, 39th Street, Mall E...
6
198.5 mi into trip|~3h 48m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
8
223.9 mi into trip|~4h 19m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
7
224.2 mi into trip|~4h 20m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
236 mi into trip|~4h 35m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from East Independence, MO to Glendale, MO, road signs begin pointing toward Memphis along the way.
Memphis
223.9 mi in|~4h 19m
Main Roads
Road
Distance
Duration
Police Officer Steven Jarvis Memorial Highway
160.1 mi
2h 51m
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Avenue of the Saints
25.1 mi
30m
I 270
11.5 mi
14m
MO 162
9.8 mi
17m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi
2m
Longest stretch:
Police Officer Steven Jarvis Memorial Highway
— 160.1 mi, about 2h 51m
Turn-by-Turn Driving Directions
Step-by-step road directions between East Independence, MO and Glendale, MO.
1
Start on East 9th Street South
79 ft·8 sec·East 9th Street South
2
Turn left onto Main Road
0.3 mi·1 min·Main Road
3
Turn left onto East Truman Road
0.7 mi·1 min·East Truman Road
4
Turn right onto Holke Road
0.9 mi·1 min·Holke Road
5
Turn straight onto South Jackson Drive
1.2 mi·2 min·South Jackson Drive
6
Turn left onto East R.D. Mize Road
0.2 mi·37 sec·East R.D. Mize Road
7
Turn right onto South Little Blue Parkway
1.7 mi·3 min·South Little Blue Parkway
8
Take the ramp
0.3 mi·38 sec
Exit 17Toward Little Blue Parkway, 39th Street, Mall EntranceUse the left lane.
9
Continue on I 70
53 mi·56 min·Dwight D. Eisenhower Highway
10
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
15
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
16
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
17
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight / slight left lanes.
18
Take the exit
0.3 mi·38 sec
Exit 25Toward I 270: Chicago, MemphisUse the slight right lane.
19
Keep slight right at fork
0.3 mi·31 sec
Toward I 270 South: MemphisUse the slight right lane.
20
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
21
Take the exit
0.4 mi·27 sec
Exit 1AToward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry RoadUse the straight / slight right lanes.
22
Keep slight right at fork
0.4 mi·43 sec
Toward I 55 South: Memphis
23
Merge onto I 55
1.5 mi·1 min·Rosa Parks Highway
24
Continue on I 55
1.8 mi·2 min·Officer Thomas G. Smith, Jr. Memorial Highway
25
Continue on I 55
160 mi·2 hr 51 min·Police Officer Steven Jarvis Memorial Highway
Use the straight / slight right lanes.
26
Take the exit
0.2 mi·25 sec
Exit 32Toward MO 162: Portageville
27
Turn right onto US 61; MO 162
0.6 mi·54 sec·US 61; MO 162
28
Turn right onto US 61; MO 162
1.0 mi·1 min·US 61; MO 162
29
Turn left onto MO 162
9.8 mi·17 min·MO 162
30
Turn left onto County Road 277
1.1 mi·4 min·County Road 277
31
Turn right onto County Road 281
1.7 mi·6 min·County Road 281
32
Turn right onto County Road 282
1.0 mi·3 min·County Road 282
33
Continue on MO VV
0.4 mi·1 min·MO VV
34
Arrive at destination
MO VV
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 208.1 miles from East Independence, MO, or about 4h into the drive.
The longest continuous stretch on this route runs about 160.1 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 92 miles or 1h 44m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 208.1 miles or 4h in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 208.1 miles or 4h
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 6h 44m
Traffic, exits, and arrival timing usually matter more near Glendale, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving East Independence, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from East Independence, MO
Aim for roughly 208 miles and 4.1 hours of wheel time on this day.
Day 2
Finish the approach into Glendale, MO
Aim for roughly 208 miles and 4.1 hours of wheel time on this day.
Your first comfortable stop window is around 92 miles from East Independence, MO.
This route usually feels better as a 2-day drive than as one long push.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on Police Officer Steven Jarvis Memorial Highway for about 160.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 208.1 mi from East Independence, MO
· 4h into the drive
The midpoint is around 208.1 miles from East Independence, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel check
Top up before Police Officer Steven Jarvis Memorial Highway if your tank is already low. That segment runs about 160.1 miles.
Overnight split
Hotel stop
For a steadier pace, wrap day one after about 208 miles or 4.1 hours on the road.
Arriving in Glendale, MO
The final approach into Glendale, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Glendale, MO.
On a multi-day trip, keep the last day a little lighter so you reach Glendale, MO with some flexibility left in the schedule.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Ste. Geneviève National Historical Park
National Historical Park
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
14 mi from route
~35 min detour
$19
near mile 229.6
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$65.07 one way
$130.14 round trip
$3.97/gal25.4 MPG avg146 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$71.44
$142.88
premium
$4.89
$80.09
$160.19
diesel
$5.61
$91.89
$183.78
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$65
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$195–$305
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 145.6 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
28 DC fast chargers
· Coverage: excellent
ChargePoint Charging Station
St Peters, Missouri
ChargePoint
1 DCFC
Blink Charging Station
Columbia, Missouri
Blink
1 DCFC
Tesla Destination Charger
Columbia, Missouri
Tesla Destination
1 DCFC
Flying J EV Charging Station
Warrenton, Missouri
Other
1 DCFC
Tesla Supercharger
Columbia, Missouri
Tesla
1 DCFC
Tesla Supercharger
Columbia, Missouri
Tesla
1 DCFC
Pilot EV Charging Station
Boonville, Missouri
Other
1 DCFC
Electrify America Charging Station
Boonville, Missouri
Electrify America
1 DCFC
Other: 9
ChargePoint: 8
Tesla Destination: 3
EV Connect: 3
Tesla: 2
Blink: 1
Electrify America: 1
EVgo: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $44 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
124.9
1
$43.70
$19.98
Efficient EV
104.1
1
$36.42
$16.65
EV Truck/SUV
166.5
2
$58.27
$26.64
Gas CO2
146 kg
EV CO2
49 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
East Independence, MO
Afternoon
in East Independence on Thursday
Local time
2:09 PM
CDT
Current temp
83°F
Sunny
S 10 mph2% chanceLive forecast
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued April 16 at 12:30PM CDT until April 16 at 1:00PM CDT by NWS Springfield MO
Special Weather Statement
Special Weather Statement issued April 16 at 12:23PM CDT by NWS Springfield MO
Destination
Glendale, MO
Afternoon
in Glendale on Thursday
Local time
2:09 PM
CDT
Current temp
55°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
28 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
8h 8m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from East Independence, MO to Glendale, MO covers 416.2 miles and takes about 8h 8m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Police Officer Steven Jarvis Memorial Highway, Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway. Expect a mix of highway and local road driving.
Consider an overnight stop or starting very early.
Yes. This route is usually more comfortable as a 2-day drive. A sensible stopping point is after roughly 208 miles on day one.
The midpoint is about 208.1 miles from East Independence, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $65.07 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 2 meaningful breaks for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 22 significant decision points across 416.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
On the drive from East Independence, MO to Glendale, MO, road signs begin pointing toward Memphis along the way.
