Origin
East Independence, MO
Afternoon in East Independence on Sunday
Local time
2:28 PM
CDT
Current temp
49°F
Unavailable
Live forecast
Trip from East Independence, MO to Perryville, MO
Drive Time
5h 53m
Distance
304.4 mi
490 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$46
one way
East Independence, MO
Ankit Rainloure
Perryville, MO
Valeria Boltneva
Trip Overview
Spanning 304.4 miles across Missouri, this trek from East Independence to Perryville typically takes about 5 hours and 53 minutes of drive time. While it is technically feasible as a single-day journey, the nearly six-hour duration means you should prepare for a full day behind the wheel. You will primarily navigate via the Dwight D. Eisenhower Highway, the Police Officer Steven Jarvis Memorial Highway, and the U.S. Submarine Veterans' Memorial Highway. Budgeting approximately $46 for fuel is a safe baseline for your planning. Since both the origin and destination are situated within the Midwest, you can expect a consistent regional feel throughout the trip. It is a straightforward route that works best if you enjoy steady, focused driving rather than frequent sightseeing stops.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
152.2 miles from East Independence, MO
A natural place for your longest stop of the day , about 2h 53m into the drive .
Drive Character
Expect a drive that transitions from major arteries to more technical local stretches. Only about 6% of your journey is categorized as highway driving, meaning you will spend the vast majority of your time navigating turn-heavy local roads. You will encounter your longest stretch of consistent driving on the Dwight D. Eisenhower Highway, which covers 135.3 miles of the trip. Because the profile is defined by these winding local sections, the drive requires more active engagement than a standard interstate cruise. Be prepared for the road character to shift significantly as you move off the main highways and onto the local segments that dominate the latter portion of your travels.
This route has more turning and local-road decision points than a simple highway run.
There are about 33 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D. Eisenhower Highway is the longest continuous segment at about 135.3 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 5 miles in.
Route Complexity
9/10
High effort - long or complex enough to need steady focus all day
This is a demanding drive. With 21 significant decision points across 304.4 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 21 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
8
5 mi into trip
|
~10m in
Take the ramp toward Little Blue Parkway, 39th Street, Mall Entrance
Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Exit 17
Toward Little Blue Parkway, 39th Street, Mall E...
6
198.5 mi into trip
|
~3h 48m in
|
US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
8
223.9 mi into trip
|
~4h 19m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
7
224.2 mi into trip
|
~4h 20m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
236 mi into trip
|
~4h 35m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Towns Along This Route
On the drive from East Independence, MO to Perryville, MO, road signs begin pointing toward Memphis along the way.
Memphis
223.9 mi in
|
~4h 19m
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Dwight D. Eisenhower Highway | 135.3 mi | 2h 34m |
| Police Officer Steven Jarvis Memorial Highway | 57.5 mi | 1h 1m |
| U.S. Submarine Veterans' Memorial Highway | 54.4 mi | 58m |
| Avenue of the Saints | 25.1 mi | 30m |
| I 270 | 11.5 mi | 14m |
| US 61 | 5.3 mi | 7m |
| Sheriff Roger I. Wilson Memorial Highway | 1.9 mi | 2m |
| Officer Thomas G. Smith, Jr. Memorial Highway | 1.8 mi | 2m |
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Turn-by-Turn Driving Directions
Step-by-step road directions between East Independence, MO and Perryville, MO.
1
Start on East 9th Street South
79 ft
·
8 sec
·
East 9th Street South
2
Turn left onto Main Road
0.3 mi
·
1 min
·
Main Road
3
Turn left onto East Truman Road
0.7 mi
·
1 min
·
East Truman Road
4
Turn right onto Holke Road
0.9 mi
·
1 min
·
Holke Road
5
Turn straight onto South Jackson Drive
1.2 mi
·
2 min
·
South Jackson Drive
6
Turn left onto East R.D. Mize Road
0.2 mi
·
37 sec
·
East R.D. Mize Road
7
Turn right onto South Little Blue Parkway
1.7 mi
·
3 min
·
South Little Blue Parkway
8
Take the ramp
0.3 mi
·
38 sec
Exit 17
Toward Little Blue Parkway, 39th Street, Mall Entrance
Use the left lane.
9
Continue on I 70
53 mi
·
56 min
·
Dwight D. Eisenhower Highway
Use the none lane.
10
Continue on I 70; US 40
32 mi
·
34 min
·
U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi
·
24 min
·
U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi
·
2 min
·
Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi
·
1 min
·
Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.9 mi
·
2 min
·
Sheriff Roger I. Wilson Memorial Highway
15
Continue on I 70; US 40
81 mi
·
1 hr 35 min
·
Dwight D. Eisenhower Highway
16
Take the exit onto US 40
0.3 mi
·
33 sec
·
US 40
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Chesterfield
17
Merge onto I 64; US 40; US 61
25 mi
·
30 min
·
Avenue of the Saints
Use the straight / slight left lanes.
18
Take the exit
0.3 mi
·
38 sec
Exit 25
Toward I 270: Chicago, Memphis
Use the slight right lane.
19
Keep slight right at fork
0.3 mi
·
31 sec
Toward I 270 South: Memphis
Use the slight right lane.
20
Merge onto I 270
11 mi
·
14 min
·
I 270
Use the none lane.
21
Take the exit
0.4 mi
·
27 sec
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Use the straight / slight right lanes.
22
Keep slight right at fork
0.4 mi
·
43 sec
Toward I 55 South: Memphis
23
Merge onto I 55
1.5 mi
·
1 min
·
Rosa Parks Highway
Use the none lane.
24
Continue on I 55
1.8 mi
·
2 min
·
Officer Thomas G. Smith, Jr. Memorial Highway
Use the none lane.
25
Continue on I 55
57 mi
·
1 hr 1 min
·
Police Officer Steven Jarvis Memorial Highway
Use the none lane.
26
Take the exit
0.2 mi
·
29 sec
Exit 135
Toward MO M: Brewer
27
Turn left onto MO M
0.6 mi
·
1 min
·
MO M
28
At end of road, turn right onto US 61; MO M
5.3 mi
·
7 min
·
US 61; MO M
29
Enter roundabout onto MO B
55 ft
·
0 sec
·
North Main Street
30
Continue on MO B
0.5 mi
·
1 min
·
North Main Street
31
Turn left onto East Saint Joseph Street
365 ft
·
18 sec
·
East Saint Joseph Street
32
Turn right onto South Spring Street
221 ft
·
9 sec
·
South Spring Street
33
Arrive at destination
South Spring Street
Trip Plan
To keep your energy high, plan for at least one dedicated stop during your 304.4-mile trek to break up the local road segments. Leaving early in the morning is your best strategy for avoiding fatigue, especially given the turn-heavy nature of the route that demands constant attention. Since you only have one planned stop in your itinerary, use that time to stretch and refuel effectively to stay within your $46 gas budget. Keep in mind that the local roads require more focus than the highway sections, so adjust your speed accordingly when you transition off the Dwight D. Eisenhower Highway. Embracing the flexibility of a single-day trip allows you to reach Perryville by evening, provided you pace your driving intervals carefully.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 152.2 miles from East Independence, MO, or about 2h 53m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 32m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 152.2 miles or 2h 53m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 50m
Traffic, exits, and arrival timing usually matter more near Perryville, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving East Independence, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from East Independence, MO
This is one driving day of about 304.4 miles and 5h 53m.
Your first comfortable stop window is around 80 miles from East Independence, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 152.2 mi from East Independence, MO · 2h 53m into the drive
Mid-route town
Meal stop
152 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 80 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 152.2 miles from East Independence, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Dwight D. Eisenhower Highway if your tank is already low. That segment runs about 135.3 miles.
Arriving in Perryville, MO
The final approach into Perryville, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Perryville, MO.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$46.24 one way
$92.47 round trip
$3.86/gal
25.4 MPG avg
107 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.25 | $50.97 | $101.94 |
| premium | $4.80 | $57.46 | $114.93 |
| diesel | $5.64 | $67.63 | $135.25 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$46
Meals
$25–$50
Total
$71–$96
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 106.5 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $32 in charging · 1 stop · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 91.3 | 1 | $31.96 | $14.61 |
| Efficient EV | 76.1 | 0 | $26.63 | $12.18 |
| EV Truck/SUV | 121.8 | 1 | $42.62 | $19.48 |
Gas CO2
107 kg
EV CO2
36 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Perryville, MO
Afternoon in Perryville on Sunday
Local time
2:28 PM
CDT
Current temp
79°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
30 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 53m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from East Independence, MO to Perryville, MO covers 304.4 miles and takes about 5h 53m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D. Eisenhower Highway, Police Officer Steven Jarvis Memorial Highway, U.S. Submarine Veterans' Memorial Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 152.2 miles from East Independence, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $46.24 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 21 significant decision points across 304.4 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 5 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 198.5 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 223.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
On the drive from East Independence, MO to Perryville, MO, road signs begin pointing toward Memphis along the way.
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Return Trip
Perryville, MO to East Independence, MOPlan the drive back the other way.
304.6 mi
5h 54m
Continue From Perryville, MO
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