The drive from Itawamba County, MS to Biloxi, MS covers 329.7 miles and takes about 6h 28m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 59, US Highway 45 Aiternate, US Highway 45 Alternate for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 88.7 miles on I 59.
At current regular gas prices, budget about $49.79 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
164.9 miles from Itawamba County, MS
A natural place for your longest stop of the day
, about 3h 18m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 28m. Total distance: 329.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 28m drive, plan rest stops for pacing.
Drive Character
This is a 6h 28m highway drive covering 329.7 miles, with most of the trip on I 59 and US Highway 45 Aiternate. The longest continuous stretch is about 88.7 miles on I 59.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 37 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 59 is the longest continuous segment at about 88.7 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 59 and US Highway 45 Aiternate. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 24.8 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 21 significant decision points across 329.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 24.8 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 169.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 258.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 21 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
7
24.8 mi into trip|~34m in
Turn left toward US 45 South, MS 6 West: Columbus, Pontotoc
Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Toward US 45 South, MS 6 West: Columbus, Pontot...
8
169.6 mi into trip|~3h 24m in|I 59
Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 59 South: Laurel, New Orleans
7
258.4 mi into trip|~5h in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
261.5 mi into trip|~5h 4m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
261.8 mi into trip|~5h 5m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Itawamba County, MS and Biloxi, MS, road signs point toward Pontotoc, New Orleans, Mobile, Gulfport, Mississippi Gulf Coast and Multi Purpose Center - among others.
Pontotoc
24.8 mi in|~34m
New Orleans
169.6 mi in|~3h 24m|via I 59
Mobile
258.4 mi in|~5h|via US 98
Gulfport
261.5 mi in|~5h 4m
Mississippi Gulf Coast
261.5 mi in|~5h 4m
Multi Purpose Center
261.8 mi in|~5h 5m
Hattiesburg
261.8 mi in|~5h 5m
Main Roads
Road
Distance
Duration
I 59
88.7 mi
1h 36m
US Highway 45 Aiternate
60.6 mi
1h 9m
US Highway 45 Alternate
54.7 mi
1h 6m
US 49
41.9 mi
49m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
I 22
14.2 mi
15m
I 20
8.1 mi
9m
Martin Luther King Drive
7.7 mi
8m
Longest stretch:
I 59
— 88.7 mi, about 1h 36m
Turn-by-Turn Driving Directions
Step-by-step road directions between Itawamba County, MS and Biloxi, MS.
1
Start on Walton Road Southwest
0.2 mi·37 sec·Walton Road Southwest
2
Turn right onto MS 178
2.4 mi·4 min·MS 178
3
Turn left onto South Adams Street
2.0 mi·3 min·South Adams Street
Use the left lane.
4
Take the ramp
0.4 mi·45 sec
Toward Tupelo
5
Merge onto I 22; US 78
14 mi·15 min·I 22; US 78
6
Take the exit
0.2 mi·27 sec
Toward Auburn Road
7
Keep slight left at fork
182 ft·6 sec
8
Turn left
115 ft·2 sec
9
Turn straight onto CR 931
0.4 mi·54 sec·Auburn Road
10
Continue on North Eason Boulevard
5.1 mi·8 min·North Eason Boulevard
Use the straight lane.
11
Turn left
0.3 mi·33 sec
Toward US 45 South, MS 6 West: Columbus, PontotocUse the left lane.
12
Merge onto US 45; MS 6
1.9 mi·2 min·Martin Luther King, Junior Drive
13
Continue on US 45; US 278
7.7 mi·8 min·Martin Luther King Drive
14
Continue on US 45 ALT
1.4 mi·1 min·US 45 ALT
15
Continue on US 45 ALT
2.2 mi·2 min·US 45 ALT
16
Continue on US 45 ALT
1.5 mi·1 min·US 45 ALT
17
Continue on US 45 ALT
0.7 mi·49 sec·US 45 ALT
18
Continue on US 45 ALT
1.4 mi·1 min·US 45 ALT
19
Continue on US 45 ALT
55 mi·1 hr 6 min·US Highway 45 Alternate
Use the straight lane.
20
Continue on US 45
61 mi·1 hr 9 min·US Highway 45 Aiternate
21
Keep slight right at fork onto US 45
3.9 mi·4 min·US 45
22
Take the exit
0.5 mi·1 min
Toward I 59 South, I 20 West: Meridian
23
Merge onto I 20; I 59
6.3 mi·7 min·I 20; I 59
Use the straight / slight right lanes.
24
Continue on I 20; I 59; US 80
1.8 mi·2 min·I 20; I 59; US 80
Use the straight lane.
25
Keep slight left at fork onto I 59
89 mi·1 hr 36 min·I 59
Toward I 59 South: Laurel, New OrleansUse the slight left / slight right lanes.
26
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
27
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
28
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
29
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
30
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
31
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
32
Continue on I 110
3.2 mi·4 min·I 110
33
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
34
Turn left onto Division Street
0.6 mi·1 min·Division Street
35
Turn right onto Main Street
0.5 mi·1 min·Main Street
36
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
37
Arrive at destination
Howard Avenue
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 164.9 miles from Itawamba County, MS, or about 3h 18m into the drive.
The longest continuous stretch on this route runs about 88.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 73 miles or 1h 31m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 164.9 miles or 3h 18m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 15m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Itawamba County, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Itawamba County, MS
This is one driving day of about 329.7 miles and 6h 28m.
Your first comfortable stop window is around 73 miles from Itawamba County, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 59 for about 88.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 164.9 mi from Itawamba County, MS
· 3h 18m into the drive
The midpoint is around 164.9 miles from Itawamba County, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel check
Top up before I 59 if your tank is already low. That segment runs about 88.7 miles.
Arriving in Biloxi, MS
The final approach into Biloxi, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Biloxi, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
4 mi from route
~10 min detour
Free
near mile 22.8
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
7 mi from route
~17 min detour
Free
near mile 22.8
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$49.79 one way
$99.58 round trip
$3.84/gal25.4 MPG avg115 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$54.66
$109.32
premium
$4.56
$59.18
$118.35
diesel
$5.61
$72.79
$145.59
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$50
Meals
$25–$50
Total
$75–$100
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 115.4 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $35 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
98.9
1
$34.62
$15.83
Efficient EV
82.4
0
$28.85
$13.19
EV Truck/SUV
131.9
1
$46.16
$21.10
Gas CO2
115 kg
EV CO2
39 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
Itawamba County, MS
Afternoon
in Itawamba County on Thursday
Local time
12:54 PM
CDT
Current temp
79°F
Unavailable
Live forecast
Destination
Biloxi, MS
Afternoon
in Biloxi on Thursday
Local time
12:54 PM
CDT
Current temp
61°F
Unavailable
Live forecast
79°F
Meridian, MS
165 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
18 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 28m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Itawamba County, MS to Biloxi, MS covers 329.7 miles and takes about 6h 28m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 59, US Highway 45 Aiternate, US Highway 45 Alternate. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 164.9 miles from Itawamba County, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $49.79 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 21 significant decision points across 329.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 24.8 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 169.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 258.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Itawamba County, MS and Biloxi, MS, road signs point toward Pontotoc, New Orleans, Mobile, Gulfport, Mississippi Gulf Coast and Multi Purpose Center - among others.
Yes. Nearby national parks include Tupelo National Battlefield and Natchez Trace National Scenic Trail.
