The drive from Lexington, MS to Biloxi, MS covers 225.2 miles and takes about 4h 34m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Highway 49 South, I 55, US 49 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 80.3 miles on Highway 49 South.
At current regular gas prices, budget about $34.01 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
112.6 miles from Lexington, MS
A natural place for your longest stop of the day
, about 2h 16m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 34m. Total distance: 225.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 34m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (94%). Some complex stretches to watch for.
Drive Character
This is a 4h 34m highway drive covering 225.2 miles, with most of the trip on Highway 49 South and I 55. The longest continuous stretch is about 80.3 miles on Highway 49 South.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 24 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Highway 49 South is the longest continuous segment at about 80.3 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on Highway 49 South and I 55. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 63.2 miles in near US 49.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 16 significant decision points across 225.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 63.2 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 145.7 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 153.8 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 16 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
63.2 mi into trip|~1h 15m in|US 49
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Richland, Hattiesburg
7
145.7 mi into trip|~2h 57m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
153.8 mi into trip|~3h 6m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
157 mi into trip|~3h 10m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
157.3 mi into trip|~3h 10m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Lexington, MS and Biloxi, MS, road signs point toward Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast, Mobile and Gulfport - among others.
Hattiesburg
62.3 mi in|~1h 14m
Richland
63.2 mi in|~1h 15m|via US 49
Gulf Coast
145.7 mi in|~2h 57m
Mississippi Gulf Coast
146.1 mi in|~2h 57m|via I 59
Mobile
153.8 mi in|~3h 6m|via US 98
Gulfport
157 mi in|~3h 10m
Multi Purpose Center
157.3 mi in|~3h 10m
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
I 55
48.8 mi
54m
US 49
44.1 mi
53m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
MS 17
12.7 mi
18m
Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
8m
US 98
3.2 mi
4m
I 110
3.2 mi
4m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Turn-by-Turn Driving Directions
Step-by-step road directions between Lexington, MS and Biloxi, MS.
1
Start on MS 12; MS 17
383 ft·7 sec·MS 12; MS 17
2
Turn right onto MS 17
0.4 mi·42 sec·Yazoo Street
Use the left / straight lanes.
3
Continue on MS 17
13 mi·18 min·MS 17
4
Take the ramp
0.3 mi·40 sec
5
Merge onto I 55
49 mi·54 min·I 55
6
Take the exit
0.9 mi·1 min
Toward I 20 East, US 49 South: Meridian, Hattiesburg
7
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
8
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
9
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
10
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
11
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
12
Merge onto I 59
7.7 mi·8 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
13
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
14
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
15
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
16
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
17
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
18
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
19
Continue on I 110
3.2 mi·4 min·I 110
20
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
21
Turn left onto Division Street
0.6 mi·1 min·Division Street
22
Turn right onto Main Street
0.5 mi·1 min·Main Street
23
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
24
Arrive at destination
Howard Avenue
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 112.6 miles from Lexington, MS, or about 2h 16m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 50 miles or 1h in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 112.6 miles or 2h 16m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 43m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Lexington, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Lexington, MS
This is one driving day of about 225.2 miles and 4h 34m.
Your first comfortable stop window is around 50 miles from Lexington, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 112.6 mi from Lexington, MS
· 2h 16m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
5 mi from route
~11 min detour
Free
near mile 62.1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $24 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
67.6
0
$23.65
$10.81
Efficient EV
56.3
0
$19.71
$9.01
EV Truck/SUV
90.1
1
$31.53
$14.41
Gas CO2
79 kg
EV CO2
26 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Lexington, MS
Late night
in Lexington on Friday
Local time
5:16 AM
CDT
Current temp
78°F
Unavailable
Live forecast
Destination
Biloxi, MS
Late night
in Biloxi on Friday
Local time
5:16 AM
CDT
Current temp
61°F
Unavailable
Live forecast
62°F
Sumrall, MS
113 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
17 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 34m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Lexington, MS to Biloxi, MS covers 225.2 miles and takes about 4h 34m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Highway 49 South, I 55, US 49. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 112.6 miles from Lexington, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $34.01 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 16 significant decision points across 225.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 63.2 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 145.7 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 153.8 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Lexington, MS and Biloxi, MS, road signs point toward Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast, Mobile and Gulfport - among others.
How this page is built
Compiled and maintained by the Trip.ovh planning team at COD Solutions Oy (Helsinki). Each route is built from authoritative open government and mapping datasets rather than crowdsourced reviews. Distances and geometry come from
OSRM
over
OpenStreetMap.
Fuel cost uses
EIA
weekly regional averages.
EV charging comes from the
NREL Alternative Fuels
dataset.
National park proximity is from the
NPS API.
Pages are published only after passing our data-quality checks; our
methodology page
documents refresh cadence, editorial standards, and known limitations.
