Origin
Senatobia, MS
Evening in Senatobia on Wednesday
Local time
6:33 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Trip from Senatobia, MS to Biloxi, MS
Last recalculated Apr 15, 2026
Drive Time
5h 8m
Distance
335.4 mi
540 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$51
one way
Best Time to Leave
4 AM
4h 55m
★
6 AM
5h 8m
8 AM
5h 35m
10 AM
5h 18m
12 PM
5h 15m
3 PM
5h 19m
5 PM
5h 34m
8 PM
5h 0m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Senatobia, MS
Wikimedia Commons
Biloxi, MS
Wikimedia Commons
Trip Overview
The drive from Senatobia, MS to Biloxi, MS covers 335.4 miles and takes about 5h 8m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on West Main Street, I 20 East, Richland for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $50.65 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
167.7 miles from Senatobia, MS
A natural place for your longest stop of the day , about 2h 34m into the drive .
Drive Character
Expect a 5h 8m drive with frequent turns across 335.4 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 24 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
West Main Street is one of the defining roads on this drive.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way.
Route Complexity
3/10
Easy - simple navigation with a manageable amount of wheel time
This is a straightforward 5h 8m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
This route does not have any notably tricky sections. Most of the drive from Senatobia, MS to Biloxi, MS is straightforward, with well-signed roads and simple exits.
Main Roads
| Road | Distance | Duration |
|---|---|---|
| West Main Street | — | — |
| I 20 East | — | — |
| Richland | — | — |
| Highway 49 South | — | — |
| I 59 South | — | — |
| Lance Corporal Roy M Wheat Memorial Highway | — | — |
| US 98 East | — | — |
| US 49 | — | — |
Some road-level metrics are being recalculated.
Longest stretch:
West Main Street
— detailed segment metrics are refreshing.
Turn-by-Turn Driving Directions
Step-by-step road directions between Senatobia, MS and Biloxi, MS.
1
Start on the route
16 ft
·
1 sec
·
the route
2
Turn left
59 ft
·
3 sec
3
Turn sharp left onto West Main Street
1.0 mi
·
1 min
·
West Main Street
4
Take the ramp right
0.2 mi
·
29 sec
5
Merge slight left
170 mi
·
3 hr 3 min
6
Take the exit slight right toward I 20 East, US 49 South: Meridian, Hattiesburg
0.9 mi
·
1 min
·
I 20 East, US 49 South: Meridian, Hattiesburg
7
Keep slight right to continue on Richland, Hattiesburg
0.7 mi
·
1 min
·
Richland, Hattiesburg
8
Merge slight left onto Highway 49 South
80 mi
·
1 hr 37 min
·
Highway 49 South
9
Continue straight
0.4 mi
·
36 sec
10
Continue straight
1.1 mi
·
1 min
11
Take the exit slight right toward I 59 South: New Orleans, Gulf Coast
0.4 mi
·
36 sec
·
I 59 South: New Orleans, Gulf Coast
12
Merge slight left onto Lance Corporal Roy M Wheat Memorial Highway
7.7 mi
·
8 min
·
Lance Corporal Roy M Wheat Memorial Highway
13
Take the exit slight right toward US 98 East: Lucedale, Mobile
3.2 mi
·
4 min
·
US 98 East: Lucedale, Mobile
14
Take the exit slight right toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
0.3 mi
·
44 sec
·
US 49: Wiggins, Gulfport, Mississippi Gulf Coast
15
Keep slight left to continue on Multi Purpose Center, Hattiesburg
0.2 mi
·
28 sec
·
Multi Purpose Center, Hattiesburg
16
Turn right
42 mi
·
49 min
17
Take the exit slight right toward MS 67 South: D'Iberville, Biloxi
0.8 mi
·
1 min
·
MS 67 South: D'Iberville, Biloxi
18
Continue on Biloxi-D'Iberville Scenic Expressway
20 mi
·
24 min
·
Biloxi-D'Iberville Scenic Expressway
19
Continue straight
3.2 mi
·
4 min
20
Take the exit slight right toward Division Street
0.4 mi
·
47 sec
·
Division Street
21
Turn left onto Division Street
0.6 mi
·
1 min
·
Division Street
22
Turn right onto Main Street
0.5 mi
·
1 min
·
Main Street
23
Turn left onto Howard Avenue
92 ft
·
3 sec
·
Howard Avenue
24
Arrive at your destination
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 167.7 miles from Senatobia, MS, or about 2h 34m into the drive.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 74 miles or 1h 7m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 167.7 miles or 2h 34m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 12m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Senatobia, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Senatobia, MS
This is one driving day of about 335.4 miles and 5h 8m.
Your first comfortable stop window is around 74 miles from Senatobia, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 167.7 mi from Senatobia, MS · 2h 34m into the drive
Mid-route town
Meal stop
168 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 74 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 167.7 miles from Senatobia, MS, which is a good place for a longer meal and fuel stop.
Arriving in Biloxi, MS
The final approach into Biloxi, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Biloxi, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$50.65 one way
$101.31 round trip
$3.84/gal
25.4 MPG avg
117 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.21 | $55.61 | $111.21 |
| premium | $4.56 | $60.20 | $120.40 |
| diesel | $5.61 | $74.05 | $148.10 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$51
Meals
$25–$50
Total
$76–$101
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 117.4 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $35 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 100.6 | 1 | $35.22 | $16.10 |
| Efficient EV | 83.9 | 0 | $29.35 | $13.42 |
| EV Truck/SUV | 134.2 | 1 | $46.96 | $21.47 |
Gas CO2
117 kg
EV CO2
39 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Biloxi, MS
Evening in Biloxi on Wednesday
Local time
6:33 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 8m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Senatobia, MS to Biloxi, MS covers 335.4 miles and takes about 5h 8m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are West Main Street, I 20 East, Richland. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 167.7 miles from Senatobia, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $50.65 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a straightforward 5h 8m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
This route does not have any notably tricky sections. Most of the drive from Senatobia, MS to Biloxi, MS is straightforward, with well-signed roads and simple exits.
The route from Senatobia, MS to Biloxi, MS does not surface many named destination signs beyond the main corridor.
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