Drive Time
4h 27m
Distance
205.1 mi
330 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$31
one way
Photo: 大 董
If you are planning to travel between Greenwood and Greenville, expect a journey covering 205.1 miles that typically takes 4 hours and 27 minutes. This route is designed as a single-day trip, making it highly efficient for those looking to reach their destination without an overnight stay. You will primarily utilize US 278, the Pontotoc Parkway West, and I-22 to navigate through the Southeast. Budgeting around $31 for fuel should cover your needs for the duration of the drive. Because this trip remains entirely within Mississippi, you can anticipate a consistent regional feel throughout your transit.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
102.5 miles from Greenwood, MS
A natural place for your longest stop of the day , about 2h 15m into the drive .
This highway-focused drive is built for speed and efficiency, with 97% of the journey spent on major thoroughfares. You should prepare for a significant amount of time on the open road, as the longest uninterrupted stretch spans 126.7 miles along US 278. The character of the drive is straightforward and consistent, lacking the technical twists of local backroads in favor of a steady interstate pace. Expect a high-speed experience that prioritizes reaching your destination quickly rather than meandering through smaller corridors.
This is a straightforward highway drive that stays mostly on US 278 and Pontotoc Parkway West. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near Dorsey Evergreen Road.
Demanding - plan breaks and stay ahead of the key maneuvers
This is a demanding drive. With 17 significant decision points across 205.1 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (Dorsey Evergreen Road): Navigation decision point; at 0.1 miles (Dorsey Evergreen Road): Highway fork - watch signs carefully; at 25.9 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
These are the spots where you need to pay the most attention. Preview them before you drive.
Turn left onto Dorsey Evergreen Road
Navigation decision point
Keep slight right at fork onto Dorsey Evergreen Road
Highway fork - watch signs carefully
Take the exit toward MS 9 South: Sherman, Pontotoc
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Turn left onto MS 9
Lane positioning matters here
Take the exit toward US 278 West, MS 6 West: Oxford, University of Mississippi
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Between Greenwood, MS and Greenville, MS, road signs point toward Pontotoc and University Of Mississippi.
Pontotoc
University Of Mississippi
| Road | Distance | Duration |
|---|---|---|
| US 278 | 126.7 mi | 2h 41m |
| Pontotoc Parkway West | 29.8 mi | 34m |
| I 22 | 16.8 mi | 18m |
| MS 9 | 9.8 mi | 11m |
| MS 182 | 8.7 mi | 12m |
| MS 178 | 4.8 mi | 6m |
| Dorsey Evergreen Road | 2.9 mi | 11m |
| North Broad Street | 1.4 mi | 2m |
Step-by-step road directions between Greenwood, MS and Greenville, MS.
Start on Greenwood Hopewell Road
Turn left onto Dorsey Evergreen Road
Keep slight right at fork onto Dorsey Evergreen Road
At end of road, turn right onto Bankhead Road Southwest
Turn left onto Dorsey Evergreen Road
Turn left onto MS 178
Turn right onto MS 371
Take the ramp
Merge onto I 22; US 78
Take the exit
Turn slight left
Turn left onto MS 9
Take the exit
Merge onto US 278; MS 6
Keep slight right at fork onto US 278; MS 6
Continue on MS 6; US 278
Continue on US 278; MS 6
Take the exit onto US 278
Turn right onto Griffin Road
Turn left onto Old Hwy 61
Turn straight onto North Broad Street
Turn right onto MS 182
Turn right onto South Main Street
Turn right onto MS 814
Arrive at destination
Since this is a 205.1-mile trek, planning for at least one dedicated stop will help keep your energy levels consistent behind the wheel. Given the reliance on major highways like I-22, try to avoid peak commuting hours to ensure you maintain your estimated 4-hour and 27-minute arrival time. Keep a close eye on your fuel gauge during that long 126.7-mile stretch on US 278, as service station intervals may be less frequent than on the interstate portions. Having a $31 fuel budget set aside is a smart way to streamline your planning before you pull out of Greenwood.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 45m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 102.5 miles or 2h 15m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 37m
Traffic, exits, and arrival timing usually matter more near Greenville, MS than in the middle of the route.
Open the route before leaving Greenwood, MS so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenwood, MS
This is one driving day of about 205.1 miles and 4h 27m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 102.5 mi from Greenwood, MS · 2h 15m into the drive
Mid-route town
Meal stop
103 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 102.5 miles from Greenwood, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before US 278 if your tank is already low. That segment runs about 126.7 miles.
The final approach into Greenville, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Greenville, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$31.35 one way
$62.71 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.26 | $34.39 | $68.78 |
| premium | $4.61 | $37.22 | $74.45 |
| diesel | $5.64 | $45.57 | $91.13 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$31
Meals
$25–$50
Total
$56–$81
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 71.8 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $22 in charging · 0 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 61.5 | 0 | $21.54 | $9.84 |
| Efficient EV | 51.3 | 0 | $17.95 | $8.20 |
| EV Truck/SUV | 82 | 1 | $28.71 | $13.13 |
Gas CO2
72 kg
EV CO2
24 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Late night in Greenwood on Sunday
Local time
3:58 AM
CDT
Current temp
65°F
Forecast unavailable right now
Destination
Late night in Greenville on Sunday
Local time
3:58 AM
CDT
Current temp
67°F
Forecast unavailable right now
Along the Route
64°F
Memphis, TN
103 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
An early start around 7-8 AM gets you there with plenty of daylight left.
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